Naloxone and play fighting in juvenile rats

Beatty, William W.; Costello, Kevin B.

doi:10.1016/0091-3057(82)90470-1

Cited by 73 publications

(41 citation statements)

References 13 publications

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“…The mu-opioid receptor agonist morphine significantly increases social play at low to moderate doses, whereas the non-specific opiate receptor antagonist, naloxone, significantly decreases social play Beatty & Costello, 1982;Siegel, Jensen & Panksepp, 1985;Panksepp, Jalowiec, DeEskinazi & Bishop, 1985;Jalowiec, Calcagnetti & Fanselow, 1989;Normansell & Panksepp, 1990;Panksepp & Lensing, 1990). Stimulation of opioid systems may increase social play by promoting a state of social comfort and thus, assertiveness (Vanderschuren et al, 1997).…”

Section: Introductionmentioning

confidence: 96%

“…Chronic administration of naloxone reduces play behavior by mitigating the reinforcing value of endogenous opiates released during play (Panksepp et al, 1984). Several studies of rats have shown acute affects of naloxone on play behavior, over a time course shorter than would be expected for an effect mediated by reversal of reinforcement Beatty and Costello, 1982;Panksepp et al, 1984;Panksepp et al, 1985;Siegel & Jensen, 1986;Normansell & Panksepp, 1990). However, those studies were conducted using animals that had been socially isolated prior to testing, a manipulation that primes juvenile rats to exhibit elevated levels of social play behavior, presumably by increasing the motivation for social reward (Panksepp, 1981;Panksepp et al, 1984;.…”

Section: Introductionmentioning

confidence: 98%

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Morphine administration selectively facilitates social play in common marmosets*†

Guard

Newman

Roberts

2002

Developmental Psychobiology

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Common marmosets (Callithrix jacchus) form extended families, and several cohorts of young may reside together. Play is shown extensively among the offspring. We hypothesized that opiate activity modulates social play, and predicted that administration of morphine (0.5 mg/kg) would facilitate social play, whereas pretreatment with naloxone (0.5 mg/kg) would block morphine's effects. Morphine administration was associated with significantly increased social play, and the effect of morphine was attributable to the focal subject, since play initiated by others was unaffected by treatment. Non-social categories of play, such as object manipulation and locomotor play, and affiliative behaviors, such as time spent huddled, were unaffected by treatment. Twittering and play face, behaviors used by young during play, also increased after morphine administration. Pretreatment with naloxone blocked morphine's effects. Total activity was significantly increased by morphine administration. We conclude that social play is specifically facilitated by opiate activation, whereas other categories of play behavior and social behavior were unaffected by morphine. Thus, social play represents a distinct category of social behavior in juvenile common marmosets with regulatory processes that are unique from other types of social behavior.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

Morphine administration selectively facilitates social play in common marmosets*†

Guard

Newman

Roberts

2002

Developmental Psychobiology

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“…Like other self-rewarding behaviours, play has been shown to involve the brain dopaminergic (Siviy, 1998) and opioid systems (Panksepp, Siviy, & Normansell, 1984;Siviy, 1998;Vanderschuren, Niesink, & Van Ree, 1997). Opioid agonists generally increase play behaviour, whereas opioid antagonists decrease it (Beatty & Costello, 1982;Normansell & Panksepp, 1990). Importantly, it appears that the neocortex is not necessary for the initiation of play behaviour, as neonatal decortication does not affect its appearance or its vigour (Murphy, MacLean, &Hamilton, 1981;Panksepp, Normansell, Cox, & Siviy, 1994).…”

Section: Domain Of ''Moderate'' Intensitymentioning

confidence: 99%

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

Ekkekakis

Hall

Petruzzello

2005

Journal of Sports Sciences

307

325

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A model for systematic changes in patterns of inter-individual variation in affective responses to physical activity of varying intensities is presented, as a conceptual alternative to the search for a global dose -response curve. It is theorized that trends towards universality will emerge in response to activities that are either generally adaptive, such as moderate walking, or generally maladaptive, such as strenuous running that requires anaerobic metabolism and precludes the maintenance of a physiological steady state. At the former intensity the dominant response will be pleasure, whereas at the latter intensity the dominant response will be displeasure. In contrast, affective responses will be highly variable, involving pleasure or displeasure, when the intensity of physical activity approximates the transition from aerobic to anaerobic metabolism, since activity performed at this intensity entails a trade-off between benefits and risks. Preliminary evidence in support of this model is presented, based on a reanalysis of data from a series of studies.

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“…Social play is rewarding for adolescent rats (Calcagnetti and Schechter, 1992;Humphreys and Einon, 1981;Normansell and Panksepp, 1990;van den Berg et al, 1999b) and it is modulated by neural systems involved in reward and motivation, such as the opioid and dopaminergic systems (Vanderschuren et al, 1997;Siviy, 1998). Thus, treatment with morphine enhances (Niesink and Van Ree, 1989;Panksepp et al, 1985;Vanderschuren et al, 1995a) and treatment with opioid antagonists decreases social play behavior (Beatty and Costello, 1982;Panksepp et al, 1985;Siegel and Jensen, 1986;Siegel et al, 1985;Vanderschuren et al, 1995c). The role of dopaminergic neurotransmission in the modulation of social play is less clear, as both increases and decreases in social play behavior have been reported after treatment with dopamine receptor agonists (Niesink and Van Ree, 1989;Siviy et al, 1996;Vanderschuren et al, 1997Vanderschuren et al, , -2008Siviy, 1998).…”

Section: Introductionmentioning

confidence: 99%

Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

Trezza¹,

Vanderschuren²

2008

European Neuropsychopharmacology

118

119

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We have recently shown that the pharmacological mechanisms through which cannabinoid and opioid drugs influence social play behavior in adolescent rats can be partially dissociated. Here, we characterize the effects of the direct cannabinoid agonist WIN55,212-2, the indirect cannabinoid agonist URB597 and the opioid agonist morphine on social play at the behavioral level. By treating either one or both partners of the test dyad, we show that these drugs differentially affect play solicitation and play responsiveness. By testing these drugs in animals which were either familiar or unfamiliar to the test cage, we show that environmental factors differentially modulate the effects of cannabinoid and opioid drugs on social play. These results support and extend our previous findings suggesting that, although cannabinoid and opioid systems interact in the modulation of social play behavior in adolescent rats, they do so through partially dissociable behavioral and pharmacological mechanisms.

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Naloxone and play fighting in juvenile rats

Cited by 73 publications

References 13 publications

Morphine administration selectively facilitates social play in common marmosets*†

Morphine administration selectively facilitates social play in common marmosets*†

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

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