Nalidixic acid-resistant strains of Salmonella showing decreased susceptibility to fluoroquinolones in the mid-west region of the Republic of Ireland

Gorman, Rachel; Adley, Catherine C.

doi:10.1093/jac/dkg159

Cited by 11 publications

(11 citation statements)

References 5 publications

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“…and, to a lesser extent, Salmonella [19,22,[41][42][43][44][45][46][47]. However, in some regions there are still low rates of resistance, so it may still be a good option, especially because of its low cost and the possibility of oral use [23,[48][49][50][51].…”

Section: Nalidixic Acidmentioning

confidence: 99%

Antibiotics for the empirical treatment of acute infectious diarrhea in children

Diniz-Santos¹,

Silva²,

Silva³

2006

Braz J Infect Dis

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While the routine use of antibiotics for infectious diarrhea in children must be avoided, because it brings little benefit in most cases and is associated with the risk of increasing antimicrobial resistance, selected cases may require antimicrobial therapy, and the choice of the antimicrobial agent often has to be made empirically. Physicians prescribing antimicrobials in such a setting have not only to be aware of the most likely pathogens, but also of their characteristic antimicrobial susceptibility pattern and the safety profile of the various drugs. We reviewed the literature on the use of ampicillin, beta-lactamase inhibitors, trimethoprim-sulfamethoxazole, chloramphenicol, tetracyclines, nalidixic acid, fluoroquinolones, third-generation cephalosporins, macrolides, metronidazole and malabsorbed agents in the setting of acute infectious diarrhea, and we evaluated the available information, seeking to apply it to empirical use, highlighting clinically-useful pharmacological information and patients' and pathogens' characteristics that must be taken into account for decisions about antimicrobial therapy.

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Section: Nalidixic Acidmentioning

confidence: 99%

Antibiotics for the empirical treatment of acute infectious diarrhea in children

Diniz-Santos¹,

Silva²,

Silva³

2006

Braz J Infect Dis

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“…The emergence of nalidixic acid-resistant Salmonella is a cause for concern, as fluoroquinolone and reduced fluoroquinolone resistance have been associated with nalidixic acid resistance (11,20). During this study, six different S. enterica serotype Typhimurium phage types were observed.…”

mentioning

confidence: 94%

Characterization of Salmonella enterica Serotype Typhimurium Isolates from Human, Food, and Animal Sources in the Republic of Ireland

Gorman

Adley

2004

J Clin Microbiol

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A potential epidemic clone of Salmonella enterica serotype Typhimurium DT104, and the possible emergence of S. enterica serotype Typhimurium DT104b, has been identified from the characterization of 67 S. enterica serotype Typhimurium strains from three sources, human gastroenteritis isolates, isolates from food samples, and veterinary isolates, by antimicrobial resistance profiling, phage typing, and pulsed-field gel electrophoresis. Resistance to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline was found in 77.6% of these strains.

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“…This could be potentially due to the spread of resistant strains and the overuse of antibiotics in humans and previous usage in animals (9,10,11). No resistance or reduced susceptibility to ciprofloxacin was detected in any of the isolates in this study (6).…”

mentioning

confidence: 62%

“…Little published information on the fluoroquinolone antimicrobial susceptibility of Salmonella in the Republic of Ireland is available. Previous reports indicated the potential emergence of fluoroquinolone resistance in Irish Salmonella isolates (6,7).…”

mentioning

confidence: 99%

“…It has been implicated in a number of food-borne outbreaks in the Republic of Ireland; its prevention, surveillance, and control have become a public health priority. To date, over 2,000 serotypes of Salmonella have been identified (6). The European Food Safety Authority (EFSA) has called for the monitoring of both nalidixic acid and ciprofloxacin resistance levels in this bacterium at both country-and European Unionwide levels (4).…”

mentioning

confidence: 99%

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Nalidixic Acid-Resistant Strains of Salmonella Showing Decreased Susceptibility to Fluoroquinolones in the Midwestern Region of the Republic of Ireland Due to Mutations in the gyrA Gene

Ryan¹,

Dillon²,

Adley

2011

J Clin Microbiol

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Nalidixic acid-resistant strains of Salmonella showing decreased susceptibility to fluoroquinolones in the mid-west region of the Republic of Ireland

Cited by 11 publications

References 5 publications

Antibiotics for the empirical treatment of acute infectious diarrhea in children

Antibiotics for the empirical treatment of acute infectious diarrhea in children

Characterization of Salmonella enterica Serotype Typhimurium Isolates from Human, Food, and Animal Sources in the Republic of Ireland

Nalidixic Acid-Resistant Strains of Salmonella Showing Decreased Susceptibility to Fluoroquinolones in the Midwestern Region of the Republic of Ireland Due to Mutations in the gyrA Gene

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