Naked mole‐rats are extremely resistant to post‐traumatic osteoarthritis

Abstract

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DNA methylation clocks show slower progression of aging in naked mole-rat queens

“…NMR social groups consist of a single breeding queen who mates with one to three males (favorites), while the rest of the colony are non-reproductive and most will never breed. This Hystricomorph rodent has a recorded maximum lifespan of 37 years (or more) and appears to be resistant to many age-related diseases [2][3][4][5][6][7][8] including two leading causes of death in humans: cardiovascular disease and cancer 9,10 . Strikingly, the mortality rate of this rodent defies the Gompertz-Makeham law by not increasing with age 11 .…”

Bodyweight, locomotion, and behavioral responses of the naked mole rat (Heterocephalus glaber) to lipopolysaccharide administration

“…In NMR, the immune system exhibits some peculiarities in terms of cellular composition with a predominance of myeloid lineage cells and a lack of natural killer cells (Cheng et al 2017;Hilton et al 2019). It is therefore likely that the immune system of the NMR is a key contributor to its prolonged health span and cancer resistance and the same has been speculated in recent reports (Zhao et al 2014;Hilton et al 2019;Kisipan et al 2020;Taguchi et al 2020). The establishment of this animal as a model for aging, cancer, and inflammatory diseases, therefore, requires characterization of the immunity and its interactions with the other body systems and biological processes in the animal.…”

“…These include cancer resistance, tolerance to hypoxia, pain, and itch; and an extended lifespan and health span compared to other rodents despite high oxidative damage (Andziak et al 2006 ; Buffenstein 2008 ; Larson and Park 2009 ; Liang et al 2010 ; Smith et al 2010 ; Tian et al 2015 ; Omerbašić et al 2016 ; Tan et al 2017 ; Kurz et al 2017 ; Ruby et al 2018 ). The animal has also been shown to exhibit resistance to age-related and inflammatory conditions (Hilton et al 2019 ; Kisipan et al 2020 ; Taguchi et al 2020 ). Due to its unique biological attributes, the animal has been found of great interest in biomedical research.…”

The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology

“…Hyaluronan increases the hydration and viscoelastic properties of the surrounding extracellular matrices and spaces due to its high net‐negative charge (Engstrom‐Laurent, 1997 ). Abundant high molecular weight hyaluronan was found both in the culture media conditioned by naked mole‐rat fibroblasts and in naked mole‐rat tissues (Tian et al ., 2013 ; Taguchi et al ., 2020 ; Takasugi et al ., 2020 ). Hyaluronan was detected by multiple methods including Alcian blue staining, including all necessary controls such as treatment with specific hyaluronan‐degrading enzymes (Tian et al ., 2013 ; Taguchi et al ., 2020 ; Takasugi et al ., 2020 ).…”