Nairobi Sheep Disease Virus: a historical and epidemiological perspective

Krasteva, Stephanie; Jara, Manuel López; Frias-De-Diego, Alba; Machado, Gustavo

doi:10.1101/2020.04.13.040014

Cited by 3 publications

(1 citation statement)

References 89 publications

(107 reference statements)

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“…The lengths of these sequences are shown in Figure 5A. The family Nairoviridae contains two highly pathogenic viruses in mammals, i.e ., CCHFV and Nairobi sheep disease virus (NSDV), which have a mortality rate of 30% and 90% in humans and small ruminants, respectively (13,14). The sequences of CCHFV and NSDV are shown in red and yellow bars in the graph, respectively (Figure 5A).…”

Section: Resultsmentioning

confidence: 99%

A comprehensive list of the replication promoters of Bunyavirales reveals a unique promoter structure in Nairoviridae differing from other virus families

Neriya

Kojima

Sakiyama

et al. 2022

Preprint

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Bunyaviruses belong to the order Bunyavirales, the largest group of RNA viruses. They infect a wide variety of host species around the world, including plants, animals and humans, and pose a major threat to public health. Major families in the order Bunyavirales have tri-segmented negative-sense RNA genomes, the 5’ and 3’ ends of which form complementary strands that serve as a replication promoter. Elucidation of the mechanisms by which viral RNA-dependent RNA polymerase recognizes the promoter to initiates RNA synthesis is important for understanding viral replication and pathogenesis, and for developing antivirals. A list of replication promoter configuration patterns may provide details on the differences in the replication mechanisms among bunyaviruses. Here, by using public sequence data of all known bunyavirus species, we constructed a comprehensive list of the replication promoters comprising 40 nucleotides in both the 5’ and 3’ ends of the genome that form a specific complementary strand. We showed that among tri-segmented bunyaviruses, viruses belonging to the family Nairoviridae, including the highly pathogenic Crimean-Congo hemorrhagic fever virus, have evolved a GC-rich promoter structure that differs from that of other bunyaviruses. The unique promoter structure might be related to the large genome size of the family Nairoviridae among bunyaviruses. It is possible that the large genome architecture confers a pathogenic advantage. The promoter list provided in this report is expected to be useful for predicting virus family-specific replication mechanisms of segmented negative-sense RNA viruses.

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Section: Resultsmentioning

confidence: 99%

A comprehensive list of the replication promoters of Bunyavirales reveals a unique promoter structure in Nairoviridae differing from other virus families

Neriya

Kojima

Sakiyama

et al. 2022

Preprint

View full text Add to dashboard Cite

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Nairobi sheep disease

Krasteva¹,

Machado²

2022

CABI Compendium

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Comparative Studies of Nairobi-Sheep-Disease Virus Strains Infectivity, Immunogenicty and Cross- Protectivity in BALB/C Mice Model

P. Muriuki,

G. D,

O. Ateya

et al. 2024

International Journal of Innovative Science and Research Techno

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Nairobi sheep disease virus is a hemorrhagic virus that cause severe gastroenteritis in shoats resulting to significant morbidity and mortality in naïve small ruminants’ populations. Vaccine platform to develop efficacious vaccine against the Nairobi sheep disease virus have been unsuccessful. This research detail the comparative infection, immunogenicity, and protection of three Nairobi sheep strains; I34, 1473 and Ansell. The three strains are marked with differences in their ability to cause disease in suckling mice model. Fatality rates range from 0-50% from the virulent pathogenic 1473 strain, I34 and the seemingly less virulent Ansell strain also shown by their relative time to death. Findings of this research demonstrate that protective efficacy mediated by inactivated Nairobi sheep disease virus strain I34 conferred a stronger cross protection against homologous and heterologous strains compared to 1473 and Ansell strains. Strain I34 sera neutralization against homologous I34 strain was similar to that against Entebe strain providing evidence of possible antigenic homology. Vaccine developed from I34 strain will protect against multiple strains of Nairobi sheep disease virus; 1473, Ansell and Entebe strain. Understanding immune response in mice elicited by different Nairobi sheep disease virus strains will facilitate development of a more efficacious vaccine. Using formalin inactivated NSDV vaccine, I34 strain showed complete protection from homologous and a partial protection heterologous strains in in vitro assay. Protection was associated by higher neutralizing antibodies against homologous and heterologous strains compared to that of 1473 and Ansell. Thus, this study deduce serum neutralizing antibody titers are associated with protection against homologous and heterologous challenge

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Nairobi Sheep Disease Virus: a historical and epidemiological perspective

Cited by 3 publications

References 89 publications

A comprehensive list of the replication promoters of Bunyavirales reveals a unique promoter structure in Nairoviridae differing from other virus families

A comprehensive list of the replication promoters of Bunyavirales reveals a unique promoter structure in Nairoviridae differing from other virus families

Nairobi sheep disease

Comparative Studies of Nairobi-Sheep-Disease Virus Strains Infectivity, Immunogenicty and Cross- Protectivity in BALB/C Mice Model

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