Nailfold videocapillaroscopy in primary antiphospholipid syndrome (PAPS)

Vaz, João Luiz Pereira; Dancour, M. A. A.; Bottino, Daniel; Bouskela, Eliete

doi:10.1093/rheumatology/keh233

Cited by 40 publications

(21 citation statements)

References 12 publications

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“…Chronic illnesses such as systemic lupus erythematosus, scleroderma [48], systemic sclerosis [49], antiphospholipid syndrome [50], connective tissue disease [51], diabetes mellitus [52] and Raynaud's Phenomenon [49] have been readily identified via specific physiological markers at the capillary level such as increased vessel permeability (haemorrhaging) [2,3], the presence of avascular areas, enlarged loops, poor circulation, and increased tortuosity [29]. In addition, the identification of such ailments has not been limited to solely systemic diseases.…”

Section: Clinical Implications Of Blood Flow Assessmentsmentioning

confidence: 99%

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

Daly

Leahy

2012

Journal of Biophotonics

106

108

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Physics has delivered extraordinary developments in almost every facet of modern life. From the humble thermometer and stethoscope to X‐Ray, CT, MRI, ultrasound, PET and radiotherapy, our health has been transformed by these advances yielding both morphological and functional metrics. Recently high resolution label‐free imaging of the microcirculation at clinically relevant depths has become available in the research domain. In this paper, we present a comprehensive review on current imaging techniques, state‐of‐the‐art advancements and applications, and general perspectives on the prospects for these modalities in the clinical realm. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Section: Clinical Implications Of Blood Flow Assessmentsmentioning

confidence: 99%

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

Daly

Leahy

2012

Journal of Biophotonics

106

108

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“…Further evidence of vessel wall abnormalities comes from a higher prevalence of renal artery stenosis in aPL-positive patients with SLE [22]. Nailfold video capillaroscopy in patients with primary APS showed abnormal morphology with smaller capillary diameters than controls, although these changes could not be correlated with impairment of functional parameters [24]. Even at the capillary level there may be abnormalities.…”

Section: Laboratory Criteriamentioning

confidence: 99%

Renal manifestations of the antiphospholipid syndrome

D’Cruz

2009

Curr Rheumatol Rep

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The antiphospholipid syndrome is characterized by recurrent arterial and venous thromboses and pregnancy morbidity in association with antiphospholipid antibodies. Recurrent thrombotic events are associated with significant morbidity and mortality. Renal involvement encompasses the whole renal vasculature and may lead to proteinuria, renal impairment, hypertension, and end-stage renal failure. Renal involvement is especially difficult to distinguish from glomerulonephritis when the antiphospholipid syndrome develops in patients with systemic lupus erythematosus. This article reviews the diagnosis and treatment of the major features of this syndrome, with particular reference to the kidney.

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“…Eine neuere Studie bestätigte, dass die Nagelbettmorphologie bei Patienten mit APS verändert ist. Keine Korrelation ergab sich mit der Verminderung funktioneller Parameter [35].…”

Section: Antiphospholipidsyndromunclassified

Kapillarmikroskopie und rheumatische Erkrankungen: State of the art

et al. 2006

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Nailfold capillaroscopy (NVC) represents the best method for analyzing microvascular abnormalities in rheumatic diseases. Raynaud's phenomenon (RP) represents the most frequent clinical aspect of microvascular involvement and is a key feature of several such diseases. Under normal conditions or in primary RP (exclusion by the cold-exposure test), the normal nailfold capillaroscopic pattern shows a regular disposition of the capillary loops within the nail bed. However, in subjects suffering from secondary RP, one or more alterations in the capillaroscopic findings should alert the physician to search for an underlying connective tissue disease. Architectural disorganization, giant capillaries, hemorrhages, loss of capillaries and avascular areas characterize more than 95% of patients with overt systemic sclerosis (scleroderma, SSc). Therefore, the term "scleroderma pattern", includes all capillaroscopic changes typical of the microvascular involvement in SSc. The capillaroscopic aspects observed in dermatomyositis and in undifferentiated connective tissue disease are generally reported as "scleroderma-like patterns". This peripheral microangiopathy can be effectively detected early in the course of the disease and studied in detail by nailfold capillaroscopy or, better, with NVC. In addition, early differential diagnosis between primary and secondary RP is the greatest advantage NVC has to offer. In addition, interesting capillaroscopic changes have been observed in systemic lupus erythematosus, antiphospholipid syndrome and Sjögren's syndrome. However, further epidemiological and clinical studies are needed to better standardize NVC patterns.

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Nailfold videocapillaroscopy in primary antiphospholipid syndrome (PAPS)

Abstract: Our results suggest that nailfold capillary morphology is altered in patients with PAPS, but these changes could not be correlated to impairment of functional parameters.

Cited by 40 publications

References 12 publications

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

Renal manifestations of the antiphospholipid syndrome

Kapillarmikroskopie und rheumatische Erkrankungen: State of the art

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