Nailfold capillaroscopic changes in patients with chronic viral hepatitis

Pancar, Gunseli Sefika; Kaynar, Taner

doi:10.1016/j.mvr.2019.103970

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…Similar to our observations, capillary tortuosity, capillary enlargement and alterations of the distribution were common findings in the chronic phase of both diseases, which have been well characterized by the presence of extrahepatic pathological manifestations on a micro- and macro-vascular basis. The authors also concluded that capillaroscopy could be able to identify the microvascular damage as a result of endothelial injury secondary to the viral disease, mainly through immune-mediated mechanisms ( Pancar et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement

Natalello

Luca

Gigante

et al. 2021

Microvascular Research

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Objective Increasing evidence points to endothelial dysfunction as a key pathophysiological factor in coronavirus disease-2019 (COVID-19). No specific methods have been identified to predict, detect and quantify the microvascular alterations during COVID-19. Our aim was to assess microvasculature through nailfold videocapillaroscopy (NVC) in COVID-19 patients. Methods We performed NVC in patients with a confirmed diagnosis of COVID-19 pneumonia. Elementary alterations were reported for each finger according to a semi-quantitative score. Capillary density, number of enlarged and giant capillaries, number of micro-hemorrhages and micro-thrombosis (NEMO score) were registered. Results We enrolled 82 patients (mean age 58.8 ± 13.2 years, male 68.3%) of whom 28 during the hospitalization and 54 after recovery and hospital discharge. At NVC examination we found abnormalities classifiable as non-specific pattern in 53 patients (64.6%). Common abnormalities were pericapillary edema (80.5%), enlarged capillaries (61.0%), sludge flow (53.7%), meandering capillaries and reduced capillary density (50.0%). No pictures suggestive of scleroderma pattern have been observed. Acute COVID-19 patients, compared to recovered patients, showed a higher prevalence of hemosiderin deposits as a result of micro-hemorrhages ( P = .027) and micro-thrombosis ( P < .016), sludge flow ( P = .001), and pericapillary edema ( P < .001), while recovered patients showed a higher prevalence of enlarged capillaries ( P < .001), loss of capillaries ( P = .002), meandering capillaries ( P < .001), and empty dermal papillae ( P = .006). Conclusion COVID-19 patients present microvascular abnormalities at NVC. Currently ill and recovered subjects are characterized by a different distribution of elementary capillaroscopic alterations, resembling acute and post-acute microvascular damage. Further studies are needed to assess the clinical relevance of NVC in COVID-19.

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Section: Discussionmentioning

confidence: 99%

Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement

Natalello

Luca

Gigante

et al. 2021

Microvascular Research

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“…The loop shape, flow state, flow velocity, clarity, and periloop state of microcirculation in patients with rheumatism are quite different from those of ordinary people. There are significant abnormalities in capillary morphology in patients with hepatitis B and hepatitis C [6]. The mean capillary loop density in psoriasis was significantly less than that in normal [7].…”

Section: Introductionmentioning

confidence: 89%

Blood flow characterization in nailfold capillary using optical flow-assisted two-stream network and spatial-temporal image

Chen

Wei

et al. 2023

Biomed. Phys. Eng. Express

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The blood flow velocity in the nailfold capillary is an important indicator of the status of microcirculation. The conventional manual processing method is both laborious and prone to human artifacts. A feasible way to solve this problem is to use machine learning to assist in image processing and diagnosis. Inspired by the Two-Stream Convolutional Networks, this study proposes an optical flow-assisted two-stream network to segment nailfold blood vessels. Firstly, we use U-Net as the spatial flow network and the dense optical flow as the temporal stream. The results show that the optical flow information can effectively improve the integrity of the segmentation of blood vessels. The overall accuracy is 94.01 %, the Dice score is 0.8099, the IoU score is 0.6806, and the VOE score is 0.3194. Secondly, The flow velocity of the segmented blood vessel is determined by constructing the spatial-temporal (ST) image. The blood flow velocity evaluated is consistent with the typical blood flow speed reported. This study proposes a novel two-stream network for blood vessel segmentation of nailfold capillary images. Combined with ST image and line detection method, it provides an effective workflow for measuring the blood flow velocity of nailfold capillaries.

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Segmenting nailfold capillaries using an improved U-net network

Liu

Zhou

et al. 2020

Microvascular Research

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Nailfold capillaroscopic changes in patients with chronic viral hepatitis

Cited by 7 publications

References 36 publications

Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement

Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement

Blood flow characterization in nailfold capillary using optical flow-assisted two-stream network and spatial-temporal image

Segmenting nailfold capillaries using an improved U-net network

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