Nailfold capillaroscopic changes in patients with idiopathic pulmonary arterial hypertension and systemic sclerosis-related pulmonary arterial hypertension

Corrado, A; Correale, Michele; Mansueto, Natalia; Monaco, Ilenia; Carriero, Antonio; Mele, Angiola; Colìa, Ripalta; Biase, Matteo Di; Cantatore, Francesco Paolo

doi:10.1016/j.mvr.2017.06.005

Cited by 45 publications

(74 citation statements)

References 37 publications

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“…[5][6][7][8][9][10][11] For two of the seven studies, the investigators were blinded to the diagnostic findings from other modalities, but the investigators for the remaining five studies were either not blinded or their blinding status was not defined. [5][6][7][8][9][10][11] For two of the seven studies, the investigators were blinded to the diagnostic findings from other modalities, but the investigators for the remaining five studies were either not blinded or their blinding status was not defined.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Finally, seven studies were included for this meta-analysis. [5][6][7][8][9][10][11] Elaborated searching strategies are depicted in Figure 1.…”

Section: Publication Searchmentioning

confidence: 99%

“…Seven publications met the inclusion criteria. [5][6][7][8][9][10][11] For two of the seven studies, the investigators were blinded to the diagnostic findings from other modalities, but the investigators for the remaining five studies were either not blinded or their blinding status was not defined. Moreover, patient recruitment was consecutive in six studies and not defined in one study.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

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Diagnostic value of nailfold videocapillaroscopy in systemic sclerosis secondary pulmonary arterial hypertension: a meta‐analysis

Xia

Wang

Xiao

et al. 2018

Internal Medicine Journal

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Section: Characteristics Of Studiesmentioning

confidence: 99%

“…Finally, seven studies were included for this meta-analysis. [5][6][7][8][9][10][11] Elaborated searching strategies are depicted in Figure 1.…”

Section: Publication Searchmentioning

confidence: 99%

Section: Characteristics Of Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic value of nailfold videocapillaroscopy in systemic sclerosis secondary pulmonary arterial hypertension: a meta‐analysis

Xia

Wang

Xiao

et al. 2018

Internal Medicine Journal

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“…Interestingly, Riccieri (12) demonstrated that higher NVC scores and avascular areas scores were correlated with mPAP. Corrado et al (18) observed a reduced capillary density and an increased mean capillary width and mean number of capillaries with neoangiogenesis in SSc-PAH patients compared to SSc patients without PAH evidence.…”

Section: Discussionmentioning

confidence: 97%

The role of nailfold capillaroscopy in monitoring lung involvement in systemic sclerosis

Groşeanu¹,

Paraschiva²,

Bălănescu³

et al. 2019

Ro J Rheumatol.

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The usefulness of capillaroscopy in the follow-up of scleroderma patients and the possible prognostic role for the appearance of visceral involvement is suggested by many authors but still under debate.The aim of this study was to assess the role of monitoring capillaroscopic abnormalities (qualitative and semiquantitative) in relation with parameters of interstitial lung involvement and pulmonary arterial hypertension(PAH). A strong correlation was identified between initial capillaroscopy scores and FVC (r=-.47, p=0.002), DLCO (r=-.51, p< 0.001) and sPAP (r=0.34, p<0.001). Active and late capillaroscopic pattern were correlated with diagnosis of lung fibrosis (χ2=14, p=0.007) and PAH at follow-up examinations (χ2=14,2, p=0.007). Progression of capillaroscopic pattern at follow-up evaluations was not correlated with significant worsening of lung volumes, DLCO, sPAP. Instead, progression of microangiopathy evolution score (>1) was asociated with worsening of FVC (r=0.32,p<0.001), DLCO(r=0.21,p=0.02) and new diagnosis of lung fibrosis on HRCT (r=0,19,p=0.035). Semiquantitative scoring, rather then qualitative capillaroscopic assessment can have a predictive role for new involvement or worsening of previous lung involvement (especially interstitial lung disease) in scleroderma patients, confirming the putative role of capillaroscopy as biomarker in SSc.

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“…Also a key use of NVC in the group of systemic sclerosis spectrum disorders is to distinguish the primary Raynaud's phenomenon from disease . Moreover, a successful application of NVC to evaluate and classify microvascular involvement has been reported for such pathologies as diabetes and systemic or pulmonary arterial hypertension when severe capillary alterations such as heterogeneously enlarged loops, capillary loss and neoangiogenesis can be observed . Although NVC has been demonstrated to be capable of assessing dynamic characteristics of blood flow, it has certain shortcomings and is predominantly limited to the analysis of static images and morphology of the capillary network .…”

Section: Introductionmentioning

confidence: 99%

In vivo optical imaging of the viable epidermis around the nailfold capillaries for the assessment of heart failure severity in humans

Shirshin

Gurfinkel

Matskeplishvili

et al. 2018

Journal of Biophotonics

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Heart failure (HF) is among the socially significant diseases, involving over 2% of the adult population in the developed countries. Diagnostics of the HF severity remains complicated due to the absence of specific symptoms and objective criteria. Here, we present an indicator of the HF severity based on the imaging of tissue parameters around the nailfold capillaries. High resolution nailfold video capillaroscopy was performed to determine the perivascular zone (PZ) size around nailfold capillaries, and 2-photon tomography with fluorescence lifetime imaging was used to investigate PZ composition. We found that the size of PZ around the nailfold capillaries strongly correlates with HF severity. Further investigations using 2-photon tomography demonstrated that PZ corresponds to the border of viable epidermis and it was suggested that the PZ size variations were due to the different amounts of interstitial fluid that potentially further translates in clinically significant oedema. The obtained results allow for the development of a quantitative indicator of oedematous syndrome, which can be used in various applications to monitor the dynamics of interstitial fluid retention. We therefore suggest PZ size measured with nailfold video capillaroscopy as a novel quantitative sensitive non-invasive marker of HF severity.

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Nailfold capillaroscopic changes in patients with idiopathic pulmonary arterial hypertension and systemic sclerosis-related pulmonary arterial hypertension

Cited by 45 publications

References 37 publications

Diagnostic value of nailfold videocapillaroscopy in systemic sclerosis secondary pulmonary arterial hypertension: a meta‐analysis

Diagnostic value of nailfold videocapillaroscopy in systemic sclerosis secondary pulmonary arterial hypertension: a meta‐analysis

The role of nailfold capillaroscopy in monitoring lung involvement in systemic sclerosis

In vivo optical imaging of the viable epidermis around the nailfold capillaries for the assessment of heart failure severity in humans

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