Nail Pigmentation following Timolol Maleate Therapy

Feiler-Ofry, V.; Godel, Victor; Lazar, Moshé

doi:10.1159/000309106

Cited by 25 publications

(3 citation statements)

References 7 publications

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“…Feiler‐Ofry et al 125 . published a report on a peculiar case of nail pigmentation in a female who had started timolol eye drops six months prior and noticed significant improvement after timolol discontinuation.…”

Section: Distant Cutaneous Aes Secondary To Anti‐glaucoma Eye Dropsmentioning

confidence: 99%

Dermatological adverse effects of anti‐glaucoma eye drops: a review

Patchinsky

Petitpain²,

Gillet

et al. 2022

Acad Dermatol Venereol

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Many patients are treated for glaucoma. Like other drugs, anti-glaucoma eye drops may induce dermatological adverse effects. We aim to review the dermatological adverse effects secondary to the active agents in anti-glaucoma eye drops through a literature review. In January 2020, we queried PubMed using the following MeSH terms: glaucoma/drug therapy or glaucoma, open angle/drug therapy cross-referenced with parasympathomimetics/adverse effects or adrenergic agonists/adverse effects or carbonic anhydrase inhibitors/adverse effects or prostaglandins F, synthetic/adverse effects or adrenergic beta antagonists/adverse effects or ophthalmic solutions/adverse effects. The initial search identified 1128 studies, of which 49 were excluded for being in a foreign language, 15 for not involving eye drops, 968 for not focusing on adverse dermatological effects, and 11 for insufficient documentation or redundancy. After adding 38 linked studies, we finally analyzed 123 studies. The ocular and periocular dermatological adverse effects of eye drops are contact dermatitis, hyperpigmentation, prostaglandin analog periorbitopathy, mucous membrane pemphigoid, eyelash depigmentation, skin hypertrichosis, and rare cases of melanoma and skin depigmentation. The reported distant dermatological adverse effects are psoriasis, excessive sweating, lichen planus, alopecia, toxic epidermal necrolysis, erythema multiforme, erythroderma, subacute cutaneous lupus erythematosus, nail pigmentation, and bullous pemphigoid. Most of the cutaneous adverse effects of anti-glaucoma eye drops are ocular and periocular and induced by prostaglandin analogs.Distant adverse effects are rare and sometimes questionable but should be kept in mind, especially mucous membrane pemphigoid, which could lead to blindness. The role of preservatives, such as benzalkonium chloride, should also be considered.

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Section: Distant Cutaneous Aes Secondary To Anti‐glaucoma Eye Dropsmentioning

confidence: 99%

Dermatological adverse effects of anti‐glaucoma eye drops: a review

Patchinsky

Petitpain²,

Gillet

et al. 2022

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Other cutaneous side‐effects have been previously well described; 1 –5 thus timolol is a relatively well‐known cause of contact dermatitis of the eyelids. Alopecia, maculopapular rash, urticaria and pigmentary nail changes have also been reported 2 …”

mentioning

confidence: 99%

A new cutaneous side-effect of ocular beta-blockers

Girardin¹,

Derancourt²,

Laurent³

1998

Clinical and Experimental Dermatology

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“…The side‐effects of eyedrops employed for glaucoma treatment may first manifest after years of use, and can be localized [dermatitis, conjunctivitis , and nail pigmentation ] or generalized [bullous pemphigoid , toxic epidermal necrolysis , and anaphylactic reactions ].…”

mentioning

confidence: 99%

A case of contact dermatitis caused by timolol in anti‐glaucoma eyedrops

et al. 2015

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The side-effects of eyedrops employed for glaucoma treatment may first manifest after years of use, and can be localized [dermatitis, conjunctivitis (1), and nail pigmentation (2)] or generalized [bullous pemphigoid (3), toxic epidermal necrolysis (4), and anaphylactic reactions (5)].A 70-year-old man with glaucoma was treated with eyedrops containing timolol maleate and brimonidine tartrate for > 2 years. The patient presented with erythematous and oedematous pruritic lesions on both cheeks (Fig. 1a).

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Nail Pigmentation following Timolol Maleate Therapy

Cited by 25 publications

References 7 publications

Dermatological adverse effects of anti‐glaucoma eye drops: a review

Dermatological adverse effects of anti‐glaucoma eye drops: a review

A new cutaneous side-effect of ocular beta-blockers

A case of contact dermatitis caused by timolol in anti‐glaucoma eyedrops

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