Nail fold capillaroscopy findings in patients with primary fibromyalgia

Frödin, Thomas; Bengtsson, Anders; Skogh, M

doi:10.1007/bf02239197

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…Our findings were in contrast with earlier smaller studies, suggesting evidence of microcirculatory dysfunction in FMS [ 6 – 9 , 12 ]. The present study benefits from being comparatively much larger than previous work and from having evaluated an enriched cohort of FMS patients specifically referred for objective assessment of RP symptoms.…”

Section: Discussioncontrasting

confidence: 99%

“…Recent studies have reported a high frequency of RP symptoms (18.2–53.3 %) in patients with fibromyalgia syndrome (FMS) [ 3 – 6 ]. Structural and functional microvascular disturbance has been reported in FMS compared with healthy controls [ 6 – 9 ]. To date, no studies have compared and contrasted RP symptom characteristics and outcome of microvascular imaging studies in FMS (reporting RP symptoms) and primary RP.…”

Section: Introductionmentioning

confidence: 99%

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Symptoms of Raynaud’s phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology

et al. 2016

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Symptoms of Raynaud’s phenomenon (RP) are common in fibromyalgia syndrome (FMS). We compared symptom characteristics and objective assessment of digital microvascular function using infrared thermography (and nailfold capillaroscopy where available) in patients with FMS (reporting RP symptoms) and primary RP. We retrospectively reviewed the outcome of microvascular imaging studies and RP symptom characteristics (captured using patient-completed questionnaire at the time of assessment) for patients with FMS (reporting RP symptoms) and patients with primary RP referred for thermographic assessment of RP symptoms over a 2-year period. Of 257 patients referred for thermographic assessment of RP symptoms between 2010 and 2012, we identified 85 patients with primary RP and 43 patients with FMS. There were no differences in RP symptom characteristics between FMS and primary RP (p > 0.05 for all comparisons). In contrast, patients with FMS had higher baseline temperature of the digits (32.1 vs. 29.0 °C, p = 0.004), dorsum (31.9 vs. 30.2 °C, p = 0.005) and thermal gradient (temperature of digits minus temperature of dorsum; +0.0 vs. −0.9 °C, p = 0.03) compared with primary RP. Significant differences between groups persisted following local cold challenge. In primary RP, patient reporting “blue” digits, bi-phasic and tri-phasic RP was associated with lower digital perfusion. In contrast, no associations between skin temperature and RP digital colour changes/phases were identified in FMS. Our findings suggest that symptoms of RP in FMS may have a different aetiology to those seen in primary RP. These findings have potential implications for both the classification of RP symptoms and the management of RP symptoms in the context of FMS. Digital colour changes reported by patients might reflect the degree of digital microvascular compromise in primary RP.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Symptoms of Raynaud’s phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology

et al. 2016

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“…Similarly, Morf et al,[ 6 ] in 10 patients with primary fibromyalgia, observed a significantly lower capillary number, more capillary dilatations, and irregular formations compared to healthy controls. Analogous are also the observations of Frödin et al,[ 7 ] who found no hemorrhages or avascular areas in 10 patients with primary fibromyalgia. Based on qualitative analysis of the capillaroscopic images, non-specific findings were detected, i.e., moderate enlargement of capillary loops, slight variations in caliber, and slight tortuosity.…”

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confidence: 83%

Comment on “the evaluation of nailfold capillaroscopy pattern in patients with fibromyalgia”

Lambova

2021

Arch Rheumatol

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“…These patients present with Raynaud's phenomenon and intolerance to cold [2]. Frodin and colleagues, using nailfold capillaroscopy in FM patients, found slight morphological changes, such as moderate enlargement of capillary loops and variations in calibre [3]. Jeschonneck and colleagues showed decreased microcirculatory blood flow above tender points in FM patients [4].…”

Section: Introductionmentioning

confidence: 99%

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et al. 2005

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This unblinded preliminary case-control study was done to demonstrate functional and structural changes in the microcirculation of patients with primary fibromyalgia (FM). We studied 10 women (54.0 ± 3.7 years of age) with FM diagnosed in accordance with the classification criteria of the American College of Rheumatology, and controls in three groups (n = 10 in each group) -age-matched women who were healthy or who had rheumatoid arthritis or systemic scleroderma (SSc). All 40 subjects were tested within a 5-week period by the same investigators, using two noninvasive methods, laser fluxmetry and capillary microscopy. The FM patients were compared with the healthy controls (negative controls) and with rheumatoid arthritis patients and SSc patients (positive controls). FM patients had fewer capillaries in the nail fold (P < 0.001) and significantly more capillary dilatations (P < 0.05) and irregular formations (P < 0.01) than the healthy controls. Interestingly, the peripheral blood flow in FM patients was much less (P < 0.001) than in healthy controls but did not differ from that of SSc patients (P = 0.73). The data suggest that functional disturbances of microcirculation are present in FM patients and that morphological abnormalities may also influence their microcirculation.

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Nail fold capillaroscopy findings in patients with primary fibromyalgia

Cited by 8 publications

References 11 publications

Symptoms of Raynaud’s phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology

Symptoms of Raynaud’s phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology

Comment on “the evaluation of nailfold capillaroscopy pattern in patients with fibromyalgia”

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