Nail dystrophy in cutaneous T-cell lymphoma

Dalziel, K.; Telfer, Nicholas R.; Dawber, R.P.R.

doi:10.1111/j.1365-2133.1989.tb01333.x

Cited by 16 publications

(17 citation statements)

References 3 publications

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“…Tomsick [13 ]first described the presence of subungual hyperkeratosis in a patient with multiple MF plaques and circulating Sézary cells. Dalziel et al [10] similarly described marked subungual hyperkeratosis with roughened nail plates and loss of normal sheen in an elderly woman with true erythrodermic SS. A review of 5 SS cases found that all 5 patients presented with splinter hemorrhages in at least 5 nails.…”

Section: Discussionmentioning

confidence: 99%

“…Nail involvement is a common clinical feature of SS that may include yellow discoloration, nail plate thickening [10,11,12], subungual hyperkeratosis [10,13,14,15], onychodystrophy [15], splinter hemorrhages [14], onychomadesis [12,15], trachyonychia [15], and/or indentations of the nail [14]. Tomsick [13 ]first described the presence of subungual hyperkeratosis in a patient with multiple MF plaques and circulating Sézary cells.…”

Section: Discussionmentioning

confidence: 99%

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Nail Alterations in Cutaneous T-Cell Lymphoma: A Case Series and Review of Nail Manifestations

Bishop

Wulkan

Kerdel

et al. 2015

Skin Appendage Disord

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Background: Cutaneous T-cell lymphoma (CTCL) encompasses a broad range of lymphoproliferative diseases affecting the skin and can be clinically misleading due to its variable presentation. Nail alterations commonly appear in advanced-stage mycosis fungoides and true Sézary syndrome; however, they may be present in any stage of the disease. Although proper recognition of nail involvement in CTCL has both clinical and therapeutic value, specific nail findings have been infrequently described in the current literature. Observations: We describe 4 patients with CTCL who presented with clinically significant nail alterations. The most common findings were nail discoloration, thickening, crumbling, onycholysis, and onychomadesis. Other notable findings included splinter hemorrhages, subungual hyperkeratosis, and anonychia. Conclusions and Message: The described cases illustrate many of the documented nail findings associated with CTCL and emphasize the variable nature of nail manifestations. The presence of specific nail alterations should increase the clinical suspicion of CTCL - especially in patients with concomitant systemic and/or cutaneous manifestations - and early biopsy specimens should be taken for diagnosis. Nail alterations should also be accurately described and monitored in all patients with biopsy-confirmed CTCL to help identify treatment response and detect disease recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nail Alterations in Cutaneous T-Cell Lymphoma: A Case Series and Review of Nail Manifestations

Bishop

Wulkan

Kerdel

et al. 2015

Skin Appendage Disord

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“…Nail fragility was another finding in our study, which was manifested with nail plate destruction and fragility. In the literature, we have found one case report by Dalziel et al [9] of 20-nail dystrophy in a patient with progressive cutaneous T-cell lymphomas.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentations of nail involvement in previous case reports included subungual hyperkeratosis, onycholysis, onychomadesis, yellow discoloration, thinning of the nail plate, splinter hemorrhage, and 20-nail dystrophy [2,3,4,5,6,7,8,9,10]. …”

Section: Discussionmentioning

confidence: 99%

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Nail Changes in Early Mycosis Fungoides

Ehsani

Nasimi

Azizpour

et al. 2017

Skin Appendage Disord

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Background: Mycosis fungoides (MF) has a wide range of clinical presentations and it has been reported rarely to involve the nail apparatus. Objective: We intended to evaluate the frequency and characteristics of nail changes in patients with biopsy-proven MF. Methods: A retrospective analysis of 60 patients with MF who were evaluated at our cancer center from 2013 to 2014 was performed to identify patients with nail changes. Histological examinations of the skin around the nail apparatus were obtained from 10 patients with periungual skin erythema and scaling. Results: In 45 patients out of 60 cases, the skin around the nail apparatus was normal, and only in 5 patients of these 45 cases, nail changes were detected. These changes included leukonychia, longitudinal ridging, nail thickening, and opacity. In the remaining 15 patients, erythema and scaling was observed in periungual skin, and 13 of them demonstrated nail changes including longitudinal ridging, nail thickening, fragility of the nail plate, subungual hyperkeratosis, pigmented nail band, Beau's lines, onychomadesis, koilonychia, nail thinning, distal notching, subungual debris, leukonychia, and pitting. In biopsies of periungual skin, none of 10 cases revealed histological findings consistent with MF. Conclusions: Evidence of nail changes was observed in 18 cases (30%). The most common nail changes detected in MF patients included longitudinal ridging, nail thickening, nail fragility, and leukonychia.

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Ungueotropic T-Cell Lymphoma

Harland¹

2006

Arch Dermatol

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Nail dystrophy in cutaneous T-cell lymphoma

Abstract: A case is reported of cutaneous T-cell lymphoma in an elderly woman. Dystrophy of all 20 nails was caused by a lymphomatous infiltrate of the nail apparatus.

Cited by 16 publications

References 3 publications

Nail Alterations in Cutaneous T-Cell Lymphoma: A Case Series and Review of Nail Manifestations

Nail Alterations in Cutaneous T-Cell Lymphoma: A Case Series and Review of Nail Manifestations

Nail Changes in Early Mycosis Fungoides

Ungueotropic T-Cell Lymphoma

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