Nail dystrophy and bony involvement in chronic sarcoidosis

Santoro, Frank; Sloan, Brett

doi:10.1016/j.jaad.2008.10.019

Cited by 31 publications

(23 citation statements)

References 10 publications

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“…A detailed clinical history and a thorough dermatologic examination drive the diagnostic investigation, as it may reveal systemic symptoms or demonstrate characteristic skin lesions of sarcoidosis [1,6]. The histopathological study of the nail bed - or eventually of the nail fold - makes the diagnosis clear by demonstrating noncaseating epithelioid granulomas [7,13]. Losada-Campa et al [7 ]propose an interesting theory related to the pathogenesis of nail changes.…”

Section: Discussionmentioning

confidence: 99%

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Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

Noriega

Criado

Gabbi

et al. 2015

Skin Appendage Disord

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The most commonly seen nail change in sarcoidosis, often associated with chronic systemic disease, is onychodystrophy. Imaging of hands, feet and chest is of paramount importance when nail sarcoidosis is suspected, for evaluation of bone cysts and pulmonary involvement, respectively. We report 2 cases of sarcoidosis that developed nail involvement - one with pulmonary disease, and the other without any evidence of systemic involvement, which is very rare.

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Section: Discussionmentioning

confidence: 99%

“…Treatment options for nail dystrophy in sarcoidosis include systemic treatment with oral prednisone, hydroxychloroquine sulfate, high-potency topical steroids, and steroid injections into the nail fold [13]. …”

Section: Discussionmentioning

confidence: 99%

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

Noriega

Criado

Gabbi

et al. 2015

Skin Appendage Disord

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“…Nails can also be affected (5). The nail apparatus may be involved primarily as in sarcoid trachyonychia or secondarily due to underlying bone involvement (29). The differential diagnosis includes primary diseases of the nails and ungual manifestations of systemic diseases (30).…”

Section: Clinical Manifestations and Differential Diagnosismentioning

confidence: 99%

The “Mystery” of Cutaneous Sarcoidosis: Facts and Controversies

Tchernev

Cardoso

Chokoeva

et al. 2014

Int J Immunopathol Pharmacol

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The reason why the cutaneous form of sarcoidosis is well known in the literature is because of its spectrum of manifestations granting it the fame of a Great Imitator. The mystery shrouding the pathogenesis of this rare cutaneous disease is still there (in spite of the fundamental progress of the various diagnostic methods in current day medicine). The production of the morphological substrate-the epithelioid cell granuloma-which is considered to be characteristic of skin sarcoidosis, could, however, also be the end result of a reaction to i) various specific infectious agents such as Leishmaniasis cutis, coccidioidomycosis, etc., ii) certain residual bacterial or other mycobacterial antigens which, at the moment of setting the diagnosis are-by definition-non-infectious but still immunogenic, as well as iii) different tumor antigens in lesional tissue or other location. Often, differentiating between sarcodiosis and a sarcoid-like reaction, based on the updated criteria for cutaneous sarcoidosis, is problematic to downright impossible. A future characterization of the genetic signature of the two conditions, as well as the implementation of additional mandatory panels for i) the identification of certain infectious or ii) non-infectious but immunogenic and iii) tumor antigens in the epithelioid cell granuloma (or in another location in the organism), could be a considerable contribution to the process of differentiating between the two above-mentioned conditions. This will create conditions for greater accuracy when setting the subsequent therapeutic approaches.

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“…Nail involvement and bone involvement are both regarded as features of chronic and systemic sarcoidosis [12]. Momen and Al-Niaimi [5] reviewed the literature on nail sarcoidosis and reported on systemic involvement in their 33 identified cases of nail sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Nail Sarcoidosis Presenting with Longitudinal Erythronychia

Lümig

Pasch

2017

Skin Appendage Disord

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A 37-year-old woman presented with progressive longitudinal erythronychia and onychorrhexis of the toenails. She had a history of sarcoidosis of the lung and nose, which was silent without treatment at the time of presentation. Histopathological examination of a nail matrix biopsy revealed granulomas with palisading histiocytes in the connective tissue and a lymphocytic infiltrate in and around the granulomas without necrosis. Based on the clinical presentation, medical history, and histopathological examination, the diagnosis of nail sarcoidosis was made. Treatment with triamcinolone acetonide 40 mg/mL resulted in the disappearance of the onychorrhexis and a significant improvement of erythronychia. To our knowledge, a clinical presentation with longitudinal erythronychia as seen in our patient has not been previously described. Bone involvement of the underlying distal phalanges and systemic involvement can be paucisymptomatic but are present in most patients with sarcoidosis of the nails. Nail and bone involvement are both regarded as features of chronic and systemic sarcoidosis. Screening for bone and systemic involvement should be performed in all patients with nail sarcoidosis, as this may influence decisions on treatment and follow-up. Therefore, it is important to recognize longitudinal erythronychia as a possible clinical sign of nail sarcoidosis.

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Nail dystrophy and bony involvement in chronic sarcoidosis

Cited by 31 publications

References 10 publications

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

The “Mystery” of Cutaneous Sarcoidosis: Facts and Controversies

Nail Sarcoidosis Presenting with Longitudinal Erythronychia

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