Nail dyschromias

Mendiratta, Vibhu; Jain, Abhishek

doi:10.4103/0378-6323.86473

Cited by 28 publications

(24 citation statements)

References 15 publications

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“…The differential diagnosis includes the most common causes of yellow nail discoloration such as age, onychomycoses, psoriasis, pityriasis rubra pilaris, certain systemic drugs, local toxic substances (formaldehyde-based hardener varnish, ascorbic acid, iron exposure), some pigments (carotene) and the yellow nail syndrome . Other drugs are known to be responsible for yellow nail discoloration: hydroxyurea, tetracyclines, penicillamine, antimalarial drugs, angiotensin II receptor blockers, methotrexate, fluorouracil or depakote [6]. Lichen planus can also be drug induced and lead to a yellow discoloration of the 20 nails, similar to that observed in our patients [7].…”

Section: Discussionsupporting

confidence: 57%

Onychopathy Induced by Temsirolimus, a Mammalian Target of Rapamycin Inhibitor

Peuvrel

Quéreux²,

Brocard³

et al. 2012

Dermatology

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Temsirolimus belongs to the mammalian target of rapamycin (mTOR) inhibitors, targeted therapies for which indications are booming in oncology. While their tolerance is usually good, mucocutaneous toxicity is the most common, including stomatitis, rashes, edemas, pruritus, dry skin and nail disorders. The latter are common in clinical practice but have not yet been well characterized. We report 2 cases of patients who developed, after 6–7 months with temsirolimus, a dystrophy of the 20 nails with fragility, distal onycholysis, yellow discoloration, associated in 1 case with painful paronychia. Topical steroids improved the paronychia, without changing the nail dystrophy. To our knowledge, the occurrence of yellow nail discoloration with temsirolimus has never been reported before. We review the cutaneous and mucosal toxicities induced by temsirolimus and everolimus, two mTOR inhibitors used as anticancer agents and by their parent molecule sirolimus.

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Section: Discussionsupporting

confidence: 57%

Onychopathy Induced by Temsirolimus, a Mammalian Target of Rapamycin Inhibitor

Peuvrel

Quéreux²,

Brocard³

et al. 2012

Dermatology

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“…Melanocytic hyperplasia causes include lentigo, melanocytic nevi, and melanoma. Melanonychia can also be associated with syndromes such as Laugier-Hunziker (pigmentation of oral mucosa, longitudinal melanonychia, and genital melanosis), Peutz-Jegher (pigmentation of lips and oral mucosa) and hamartomatous polyps [2, 4-5]. …”

Section: Discussionmentioning

confidence: 99%

“…Pseudomonas aeruginosa infection of the nail can cause green discoloration and is known as green nail syndrome [4-5, 8-9]. Conditions associated with red dyschromia include carbon monoxide poisoning, chemotherapy, glomus tumor, and subungual hematoma, as well as longitudinal erythronychia, red lunula and transverse red bands [4-5, 7]. …”

Section: Discussionmentioning

confidence: 99%

“…Leukonychia causes include dermatological causes (alopecia areata, erythema multiforme, exfoliative dermatitis, lichen planopilaris, psoriasis, systemic lupus erythematosus), drugs (cyclosporine, cytotoxic agents, penicillamine, quinacrine, retinoids, steroids, sulphonamides), infections (leprosy, malaria), nutrition (malnutrition, pellagra, protein deficiency, zinc deficiency), poisoning (arsenic, fluoride), systemic diseases (cardiac failure, hypocalcemia, graft rejection, liver cirrhosis, liver failure, pneumonia, Raynaud’s disease, and trauma [4-5]. Yellow chromonychia can be caused by onychomycosis or yellow nail syndrome (a syndrome involving yellow dystrophic nails), lymphedema, and pleural effusions, or can be induced by antimalarial, gold-containing, hydroxyurea, penicillamine, and, tetracycline drugs [4-5].…”

Section: Discussionmentioning

confidence: 99%

“…Yellow chromonychia can be caused by onychomycosis or yellow nail syndrome (a syndrome involving yellow dystrophic nails), lymphedema, and pleural effusions, or can be induced by antimalarial, gold-containing, hydroxyurea, penicillamine, and, tetracycline drugs [4-5]. …”

Section: Discussionmentioning

confidence: 99%

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Non-Melanoma-Associated Dyschromia of the Proximal Nail Fold

DeMartinis

Cohen

2016

Cureus

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Subungual melanoma with pigmentation beneath the nail that extends to involve the proximal nail fold is referred to as Hutchinson’s sign. Black or brown subungual discoloration involving the proximal nail fold secondary to other etiologies has been referred to as pseudo-Hutchinson’s sign. Three patients with nail discoloration and concurrent dyschromia of the proximal nail fold are described: a female with a chronic subungual hematoma and pseudo-Hutchinson’s sign, a male with culture-confirmed Pseudomonas aeruginosa (P. aeruginosa) of the nail with green discoloration involving the proximal nail fold, and a male with an acute subungual hematoma with red-purple subungual discoloration affecting the proximal nail fold. PubMed was searched for the following: black, brown, chloronychia, discoloration, dyschromia, green, hematoma, Hutchinson’s sign, nail, nail fold, proximal, pseudo-Hutchinson’s sign, red, subungual melanoma, syndrome. The papers were reviewed and appropriate references evaluated. In conclusion, melanoma-associated black proximal nail fold pigmentation is referred to as Hutchinson’s sign, and non-melanoma-associated black pigmentation has been designated as pseudo-Hutchinson’s sign. Subungual nail plate discoloration extending to involve the proximal nail fold may be black, green, or red-purple in patients with melanocytic and non-melanocytic lesions, bacterial infection (Pseudomonas), and acute subungual hematoma, respectively. Instead of creating a new terminology, we suggest that non-black subungual discoloration (green or red-purple) extending to involve the proximal nail fold be referred to as pseudo pseudo-Hutchinson’s sign.

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Dyschromias in Renal Disease

Munhutu

Halder

2015

Dermatological Manifestations of Kidney Disease

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Nail dyschromias

Cited by 28 publications

References 15 publications

Onychopathy Induced by Temsirolimus, a Mammalian Target of Rapamycin Inhibitor

Onychopathy Induced by Temsirolimus, a Mammalian Target of Rapamycin Inhibitor

Non-Melanoma-Associated Dyschromia of the Proximal Nail Fold

Dyschromias in Renal Disease

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