Nail drug delivery system a review

Rathi, Apeksha R; Popat, Ritesh R.; Adhao, Vaibhav S.; Shrikhande, Vinayak N.

doi:10.18231/j.ijpca.2020.002

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…In a 'rail and groove' result, the nail plate grows forward on the nail bed, similar to how a train rides on the tracks. As we mature, the natural oil and moisture levels in nail plates decrease, resulting in the rail and groove effect 37 .…”

Section: Vertical Ridgesmentioning

confidence: 99%

“…Nail patella syndrome is thought to be caused by a sporadic gene mutation in circumstances where there seems to be no prior family history of the condition. Once nail-patella syndrome has been identified in a household, the chance of passing the condition on to offspring is 50% for each birth, regardless of the child's gender, with females being affected 10% more often 37 .…”

Section: Nail Patella Syndromementioning

confidence: 99%

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Understanding the drug delivery through nails: a comprehensive review

Bhattacharjee

Dey

Barman

et al. 2021

J. Drug Delivery Ther.

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The nail unit is the largest cutaneous musculo-skeletal appendage. The management of nail disorders is an onerous task owing to the disease manifestations and anatomical structure of the nail plate. The topical treatment of nail infections/disorders has been a centerpiece of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. However, transungual delivery had its challenges. This necessitated a lookout for novel approaches that enhanced treatment efficacy and reduced treatment time. Moreover, curing the nail condition using topical delivery has been challenging due to the lack of a validated animal model to determine the efficacy of the formulation and to establish a mathematical model that can help in predicting the desirable attributes of the formulation and permeation of various molecules through the nail plate. This review is based on publications retrieved by a selective search in PubMed. The purpose of this review is to provide an overview of nail anatomy and its disorders, factors affecting nail delivery, diagnostic procedures, current approaches, and promising approaches to treat nail infections/disorders including nail lacquers and the role of permeation enhancers, in-vitro models. This review also covers current available treatments and treatments under clinical trial. Keywords: Musculo-skeletal, Nail infection, Transungual, Mathematical model, In-vitro models.

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Section: Vertical Ridgesmentioning

confidence: 99%

Section: Nail Patella Syndromementioning

confidence: 99%

Understanding the drug delivery through nails: a comprehensive review

Bhattacharjee

Dey

Barman

et al. 2021

J. Drug Delivery Ther.

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“…13,14 Biomaterial functionalities highly depend on their selfassembly structures; the interconnecting network is ideal for extracellular matrix (ECM) mimicking scaffolds, while vesicles and micelles would be more preferred in a drug-delivery system. 15,16 However, it is challenging to predict and design desired structures, as self-assembly behaviors are versatile and sensitive to environmental conditions. Currently, researchers mostly rely on the results of experiments to understand the trend of structural changes and finally conclude the understanding with a model that appropriately describes the selfassembly mechanism.…”

Section: ■ Introductionmentioning

confidence: 99%

Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels

Wang,

Liu,

Tan

et al. 2024

ACS Appl. Mater. Interfaces

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Peptide-based hydrogels have great potential for applications in tissue engineering, drug delivery, and so on. We systematically synthesize, characterize, and investigate the selfassembly behaviors of a series of polypeptide-based penta-block copolymers by varying block sequences and lengths. The copolymers contain hydrophobic blocks of poly(γ-benzyl-Lglutamate) (PBG, B x ) and two kinds of hydrophilic blocks, poly(L-lysine) (PLL, K y ) and poly(ethylene glycol) (PEG, EG 34 ), where x and y are the number of repeating units of each block, where PBG and PLL blocks have unique functions for nerve regeneration and cell adhesion. It shows that a sufficient length of the middle hydrophilic segment capped with hydrophobic end PBG blocks is required. They first self-assemble into flower-like micelles and sequentially form transparent hydrogels (as low as 2.3 wt %) with increased polymer concentration. The hydrogels contain a microscale porous structure, a desired property for tissue engineering to facilitate the access of nutrient flow for cell growth and drug delivery systems with high efficiency of drug storage. We hypothesize that the structure of B x -K y -EG 34 -K y -B x agglomerates is beyond micron size (transparent), while that of K y -B x -EG 34 -B x -K y is on the submicron scale (opaque). We establish a working strategy to synthesize a polypeptide-based block copolymer with a wide window of sol−gel transition. The study offers insight into rational polypeptide hydrogel design with specific morphology, exploring the novel materials as potential candidates for neural tissue engineering.

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“…Due to the bond between the keratin fiber and surrounding area (disulfide, Hydrogen, electrostatic, acid-base bond) drugs show poor diffusion. New strategies need of to develop for this overcoming the problem [15].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Voriconazole Loaded Nanoemulgel for the treatment of Onychomycosis

Lavate,

Chaudhari

2023

Preprint

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Background: Voriconazole has been given a more potent antifungal action in-vitro and is the most commonly used drug for the treatment of onychomycosis. In this voriconazole-loaded nanoemulgel for the management of onychomycosis was developed and evaluated. This development preparation mainly delivers poorly aqueous soluble drugs across the nail. Different types of components, such as o/w nanoemulsions, were mildly stirred using the aqueous titration technique before being homogenized under high pressure to minimize the particle size. DOE software is used to develop various batches for the selection of optimized batches. Nanoemulsion containing was prepared by using, olive as oil, Tween 80, and PEG 400 as used as a surfactant and co-surfactant respectively. The gelling agent is Carbopol 934. Thioglycolic acid is used as a nail penetration enhancer. The optimized batch was evaluated for physical appearance, pH, viscosity, stress stability study, vesicle size, particle size, drug release, drug content, and stability study. Result: Drug polymer compatibility study show that drug and excipient are compatible with each other, The formulation was found to be clear and pH is a 5.2 it is suitable for nail pH. A nanoemulgel study of in vitro drug release revealed improved drug release, i.e. that is 68% in 8th hrs. Thus more than 90% of drug release will happen in 24th hrs. which shows good controlled release. Zone of inhibition of optimized batch was found to be 9.8mm. Conclusion: Voriconazole-loaded nanoemulsion was created in the current study by utilizing olive oil, Tween 80, and PEG 400. As a result of the drug's antifungal effectiveness against C. albicans, the F16 may be able to alleviate onychomycosis symptoms more quickly than with traditional treatment. Thus, nanoemulgel is a formulation for the topical treatment of onychomycosis that is safe and effective.

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Nail drug delivery system a review

Cited by 5 publications

References 30 publications

Understanding the drug delivery through nails: a comprehensive review

Understanding the drug delivery through nails: a comprehensive review

Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels

Formulation and Evaluation of Voriconazole Loaded Nanoemulgel for the treatment of Onychomycosis

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