“Nail” and “comb” effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

Abstract

et al. "Nail" and "comb" eff ects of cholesterol modifi ed NIPAm oligomers on cancer targeting liposomes

pH-sensitive amphiphilic copolymer brush Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA: synthesis and self-assembled micelles for controlled anti-cancer drug release

“…[1][2][3][4][5] However, there are still many key technical issues, such as poor solubility of the drugs, low bioavailability, side-effects, poor therapeutic effect and serious toxicities, to limit the further study and clinical applications. [6][7][8][9][10] In order to address these challenges, more and more polymeric vectors, such as nanoparticles, 11-13 liposomes [14][15][16] and nano-scale carriers, [17][18][19] have been developed by many researchers around the world. Among these novel drug vehicles, polymeric micelles which are generally self-assembled by amphiphilic polymers with hydrophilic and hydrophobic segments show many advantages, including high drug loading capacity, small particle size (<200 nm), controlled release behavior and easily modied.…”

Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

“…The degraded products of biodegradable nanoparticles (NPs) should also to be biocompatible. Biodegradable nanomaterials include various polymer, [6] liposome, [12,13] silicon, [14,15] organically-doped silica, [2,3,5] and calcium phosphate nanosystems. [16,17] In addition, nano-objects of hydrodynamic diameter (HD) below 10 nm are excreted by the body via the renal clearance route which prevents the toxicity associated with the bio-accumulation of particles.…”

100th Anniversary of Macromolecular Science Viewpoint: Poly(N-isopropylacrylamide)-Based Thermally Responsive Micelles

“…In turn, many PNIPAAm contained copolymers were well designed and studied, which were extensively utilized to prepare thermosensitive brushes, − hydrogels, − vesicles, , and micelles. − Five decades-long developments in the area of such polymers and their applications were reviewed in many comprehensive articles. − However, it remains difficult for PNIPAAm to attain its full potential as stimuli-responsive materials. For example, its possible depolymerization and chronic bioaccumulation in the body may greatly limit its application in the biomedical area. − Thus, continuous efforts have to be made to improve the property and explore the potential of PNIPAAm-containing polymers, leading to a renaissance of research in the field of polymer chemistry.…”