Nail abnormalities in patients with vitiligo

Topal, İlteriş Oğuz; Güngör, Şükrü; Kocatürk, Özgür; Duman, Hatice; Durmuşcan, Mustafa

doi:10.1590/abd1806-4841.20164620

Cited by 10 publications

(4 citation statements)

References 15 publications

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“…Significantly lower mean serum level was observed in patients with Longitudinal ridging60.75+12.9 and leukonychia 54.5±11.15compared to 77.71±18.99 in patients with no nail abnormalities (p value= 0.008). A case-control study conducted by Topal et al 24 2016 involving 100 patients demonstrated nail changes in 78% of patients. Longitudinal ridging was the most common finding observed in 42% of patients followed by leukonychia, splinter hemorrhage and nail plate thinning.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Ahmed

Abdulqader³

et al. 2020

Preprint

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Background: Vitiligo is an acquired autoimmune pigmentary disorder characterized by ivory white patches. Zinc is proposed to have an immune modulatory, antioxidant and antiapoptotic properties in vitiligo patients.The aim of this study is to evaluate serum zinc in vitiligo patients. Patients and methods: This is case control study conducted from December 2019 to May 2020. The study included 50 patient with vitiligo and 50 age- and sex-matched controls.A 2 ml venous blood sample was taken from patients and controls by zinc-free syringe and was measured by atomic absorption spectrophotometry. Results: The mean serum zinc level was 73.14+19.32 in patients group and 85.36+14.14 in controls group (p-value=0.005). It also was 77.65+22.07 and 82.84+14.32 in male patients and controls, respectively. In female patients, it was 70.82+17.65and in female controls was 82.88+13.79(p-value=0.02). Regarding the residence, the mean serum zinc level in patients group was 70.13+21.4 in urban and 76.39+17.73 in rural area. In controls group, mean serum zinc was 83.25+14.12 and 89.11+13.77 in urban and rural area, respectively (p-value=0.003). According to the clinical patterns of vitiligo, the mean serum zinc observed was 75.32+19.64 in vitiligo vulgaris, 70.45+21.23 in acrofacial vitiligo and 68.7+17.61 in segmental vitiligo (p-value=0.68). Conclusion: Serum zinc level was significantly low in patients with vitiligo but not associated with the type of vitiligo or family history of autoimmune diseases. It was even lower when vitiligo is associated with nail changes than vitiligo without any nail abnormalities.

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Section: Discussionmentioning

confidence: 98%

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Ahmed

Abdulqader³

et al. 2020

Preprint

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“…We reported nail lesions to occur in 13.3% (n=16) of patients presenting as longitudinal ridging 8.3% (n=10) and as leukonychia 5% (n=6). Topal IO et al 19 . 2016 conducted a case control study enrolling 100 patient with vitiligo, has also observed longitudinal ridging as the most common nail abnormality 42% (n=42) associated with vitiligo (p value=0.001).…”

Section: Discussionmentioning

confidence: 99%

Childhood Vitiligo: A Retrospective Clinico-Epidemiological Study

Ahmed

Mohammed

et al. 2020

Preprint

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Background: Vitiligo is an acquired depigmentary disorder of the skin, mucous membrane and hair follicle resulting from selective destruction of melanocytes. Aims of Study: Identify the clinico-epidemiological characteristics of childhood vitiligo. Patients and Methods: A retrospective study carried out at the dermato-venereology clinic of Salah Al-Din Hospital. A total of 120 vitiligo patients, all younger than 17 years old, were enrolled. Results: Among included patients, (40%) were male and (60%) were female (M:F=2:3). The mean age of onset was (11.5 SD 6.4 years) with (60.8%) of patients were (11-17) years old, (25%) were (6-11) years and (14.2%) were (0-5) years old. Majority of patients were from urban area (87.5%). Generalized types of vitiligo account for (56.7%) besides (22.5%), (17.5%) and (3.3%) represented focal, acrafacial and segmental vitiligo, respectively. Only (8.3%) have nail changes, presented as longitudinal ridging followed by leukonychia. Family history was positive in (37.5%) of vitiligo patients. Treatment used for vitiligo were topical corticosteroids (92.5%), topical calcineurin inhibitors (55%), NB-UVB (84.2%), and systemic steroids (30.8%). Conclusions: Majority of childhood vitiligo develops after puberty and predominantly affects female. Generalized vitiligo is the most frequent type. Atopic dermatitis is the most common associated disease.

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“… 8 These were also observed in patients with other ADs, including AITD, psoriasis, and vitiligo. 39 While the pathophysiology of these changes is not clearly understood, inflammatory cells targeting the nail may cause abnormal keratinization of the matrix, leading to nail plate changes. Abnormal nail findings in AA correlate with disease severity and poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata

Chanprapaph¹,

Mahasaksiri²,

Kositkuljorn³

et al. 2021

JIR

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Background Increased rates of autoimmune diseases (ADs) have been reported in association with alopecia areata (AA); however, the risk factors for coexisting ADs in AA patients have been poorly investigated. Objective To evaluate the prevalence and factors associated with AD comorbidities in patients with AA. Methods This case–control study included patients diagnosed with AA between January 2000 and March 2020. Individuals with AA, both with and without concomitant ADs, were statistically compared. Variables significantly associated with coexisting ADs were identified using univariate and multivariate logistic regression analyses. Multinomial logistic regression analysis was performed to identify the specific risk factors for each concomitant AD. Results Among the 615 patients with AA, comorbid ADs were found in 76 (12.4%). Autoimmune thyroid disease (AITD) exhibited the highest frequency (n = 42, 6.8%), followed by vitiligo (n = 15, 2.4%), and systemic lupus erythematosus (SLE) (n = 12, 2.0%). Logistic regression analyses revealed that female sex (odds ratio [OR] = 2.45, 95% confidence interval [CI] = 1.24–4.82; P = 0.011), nail abnormalities (OR = 2.49, 95% CI = 1.14–5.46; P = 0.023), and atopic diseases (OR = 1.98, 95% CI = 1.09–2.43; P < 0.001) were significantly associated with coexisting ADs. Regarding each concomitant AD, nail abnormalities were an associated factor for AITD (OR = 4.65, 95% CI = 1.96–7.24; P = 0.01), whereas coexisting atopic diseases were demonstrated as a predictor of vitiligo (OR = 2.48, 95% CI = 1.43–4.58; P = 0.02). Female sex (OR = 1.61, 95% CI = 1.18–4.27; P = 0.04) and family history of AD (OR = 1.85, 95% CI = 1.26–4.19; P = 0.03) were predictors of SLE. Conclusion This study suggests that female AA patients with nail abnormalities and atopic diseases have increased rates of AD comorbidities. A thorough review of systems for associated factors can help physicians screen for concomitant ADs.

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Nail abnormalities in patients with vitiligo

Cited by 10 publications

References 15 publications

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Childhood Vitiligo: A Retrospective Clinico-Epidemiological Study

Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata

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