NaHSO4•H2O as an efficient and eco-friendly catalyst for the one-pot multicomponent synthesis of β-acetamido ketones under mild and heterogeneous conditions

Abstract

A new, one-pot, four-component condensation of benzaldehyde derivatives, acetophenone derivatives, acetyl chloride and acetonitrile in the presence of sodium hydrogen sulfate as catalyst is described for the synthesis of β-acetamido ketones.

Catalytic application of a novel melamine–naphthalene-1,3-disulfonic acid metal–organic framework in the synthesis of β-acetamido ketones

“…To achieve this, it combines the Brønsted acid sites of the SO 3 H groups with the Lewis acidity of the Zr metal nodes. 95,96…”

“…Condensation of intermediate (I) with acetonitrile leads to the formation of another key intermediate (III) which reacts with the enol form of acetophenone to furnish intermediate (V). The removal of acetate molecules by hydrolysis provides the b-acetamido ketone.To achieve this, it combines the Brønsted acid sites of the SO 3 H groups with the Lewis acidity of the Zr metal nodes 95,96.…”