Naftidrofuryl and the nitrogen, carbohydrate, and lipid responses to moderate surgery.

Abstract

The effect of twice daily infusions of 200 mg naftidrofuryl on the six day cumulative losses of urinary nitrogen after moderate surgery was studied in 32 patients maintained on an intravenous infusion of 4% dextrose and saline. A previous report ofthe ability ofnaftidrofuryl to reduce loss of nitrogen was not substantiated, although changes in metabolism in the immediate postoperative period suggested that the drug might exert some advantageous metabolic effect. Further investigations with other nutritional regimens are warranted. IntroductionThe major metabolic effect of trauma or operations is to increase the net degradation of muscle protein to provide alternative energy substrates and to maintain the synthesis of visceral