Nafamostat mesilate, a noncalcium compound, as an anticoagulant, induces calcium‐dependent haemolysis when infused with packed erythrocytes

Abstract

NM and GM induce haemolysis in packed erythrocytes in the presence of citrate that is dependent on extracellular calcium.

Effects of Co-infusion of Plasma, Whole Blood and Anticogulants on Their Clotting Activities

“…However, co-infusion of RCC and other drugs results in unexpected adverse reactions in patients [7]. Moreover, we previously reported that co-infusion of RCC, nafamostat mesilate (NM) and gabexate mesilate (GM) induces hemolysis in packed erythrocytes [8]. NM is a synthetic protease inhibitor that inhibits coagulation and fibrinolysis by inactivating thrombin, plasmin, trypsin, kallikrein, coagulation factors XIIa and Xa, and complements [9][10].…”

Possible red blood cell damage due to iatrogenic transfusion filter-related mistakes during blood transfusion

“…Antibodies and/or complement proteins induce a hemolytic reaction during the acute (acute hemolytic transfusion reaction) [1] and delayed (delayed hemolytic transfusion reaction) phases [2]. Nonimmune mediated causes of transfusion-associated hemolysis include thermal injury [3], osmotic injury [4], mechanical injury [5], infection [6], drugs [7] and others. In mechanical injuries, defective blood administration causes induced transfusionassociated hemolysis [8].…”