Naevoid Malignant Melanoma: A Diagnosis of a Naevus That You Later Regret

Theodosiou, Grigorios; Johansson, Iva; Hamnerius, Nils; Svensson, Åke

doi:10.2340/00015555-2634

Cited by 9 publications

(8 citation statements)

References 3 publications

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“…The purpose of this systematic review was to provide a comprehensive overview of the specific clinical and dermoscopic features of each variant of the most frequently reported but uncommon melanomas, improving clinician skill to recognize these variants. melanoma (31 cases), [55][56][57][58][59] 1 on primary dermal melanoma (1 case), 60 3 on spitzoid melanoma (28 cases), 20,[61][62][63] and 4 on verrucous melanoma (4 cases). [64][65][66][67] One study reported both amelanotic and spitzoid melanoma cases.…”

Section: Meaningmentioning

confidence: 99%

Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma

et al. 2020

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The clinical and dermoscopic features of the vast majority of uncommon variants of cutaneous melanoma have been rarely reported, leading to difficulty in making accurate diagnoses.OBJECTIVE To define the main clinical and dermoscopic features of the most frequently reported but uncommon histologic variants of cutaneous melanoma.EVIDENCE REVIEW A 2-step systematic review of the literature was performed (from inception to November 2018) using PubMed, Embase, and Cochrane Central Register of Controlled Trials databases. The first step identified those uncommon variants of melanoma for which at least 1 case reporting dermoscopy was described in the literature. The keywords searched were melanoma, uncommon, rare, dermoscopy, and dermatoscopy. In the second step, each previously identified uncommon variant was searched for in the same databases by combining the following terms with melanoma, dermoscopy, and dermatoscopy: amelanotic, hypopigmented, animal, melanocytoma, balloon, desmoplastic, follicular, nested, nevoid, dermal, spitz*, spindle, and verrucous. The institution's database was also searched from January 2012 to September 2019 for histopathologically confirmed cases of the same melanoma variants. Each reviewer also assessed the quality of reporting in the included articles based on previously described guidelines.FINDINGS In total, 62 articles met the inclusion criteria, reporting 433 melanoma cases. An additional 56 cases of uncommon melanoma variants were retrieved from the institution's database for a total of 489 cases: 283 cases of amelanotic superficial spreading melanoma, 18 cases of animal-type and pigmented epithelioid melanocytoma, 7 cases of balloon cell melanoma, 71 cases of desmoplastic melanoma, 3 cases of follicular melanoma, 10 cases of nested melanoma, 33 cases of nevoid melanoma, 2 cases of primary dermal melanoma, 57 cases of spitzoid melanoma, and 5 cases of verrucous melanoma. These variants of melanoma occurred more frequently in women than men (147 cases vs 132 cases). Clinically, these tumors were mainly palpable (162 of 217 [74.7%]) or amelanotic (283 of 489 [57.9%]) lesions that could resemble other benign or malignant skin conditions; dermoscopy typically revealed a homogeneous pinkish background, white structures, and polymorphic vessels. The mean age of all included was 58 years (range, 1-89 years).CONCLUSIONS AND RELEVANCE Uncommon melanoma variants may resemble both inflammatory disorders and other cutaneous neoplasms, representing a diagnostic pitfall even for the most experienced dermatologist. The purpose of this systematic review was to provide an extensive and detailed overview of specific clinical and dermoscopic features of each uncommon melanoma variant, highlighting the main criteria for differentiating these variants from other benign or malignant skin lesions.

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Section: Meaningmentioning

confidence: 99%

Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma

et al. 2020

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“…The most common sites are trunk and limbs. There is male preponderance with 2:1 ratio and age group ranges from 5th-7th decade [3]. Local recurrence and metastasis to regional lymph nodes is not uncommon, having been reported in up to 50% cases with subsequent mortality of at least 25%.…”

Section: Discussionmentioning

confidence: 99%

Nevoid melanoma: a rare and intriguing variant presenting as polypoidal mass on leg

Tiwary¹,

Singh²

2020

Our Dermatol Online

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Nevoid melanoma belongs to a rare and intriguing variant of melanoma which mostly present in elderly males as asymptomatic, single, variegated smooth plaques, verrucous nodule or polypoidal tumor usually affecting trunk and extremities. Clinically, the plaque forms can be misdiagnosed as seborrheic keratosis or papilloma. Nodular lesions mimicking benign dermal nevus and nodular melanoma should always be evaluated histopathologically. The risk of local recurrence and metastasis is always present depending upon the depth of invasion, hence management is no different than other more invasive forms of melanoma. Herein, we reported a female presenting with single, painless, blackish, firm, verrucous mass on right lower leg which was biopsied and confirmed on histopathology and immunostaining with HMB45 to be as nevoid melanoma.

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“…5 Theodosiou dkk menyatakan naevoid melanoma menyerupai compound dan dermal nevus. 6 Costa dkk meneliti adanya kemiripan antara melanomas associated with blue nevus dengan celluler blue nevus. 7 Kesalahan diagnosis antara melanoma dan nevus melanositik memiliki implikasi medikolegal.…”

Section: Pendahuluanunclassified

Hubungan Tingkat Ekspresi P15 Terhadap Nevus Melanositik Dan Melanoma Maligna

Nasution

Kartika

Theodorus

2021

JKK

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Latar Belakang. Lesi melanositik memiliki gambaran morfologi dan sitomorfologi yang luas mencakup lesi jinak yaitu nevus melanositik dan lesi ganas yaitu melanoma maligna. Beberapa gambaran nevus melanositik menyerupai melanoma. p15 merupakan gen penekan tumor dan biomarker yang kuat sehingga dapat digunakan untuk membedakan antara nevus dan melanoma. Tujuan. Mengetahui hubungan tingkat ekspresi p15 pada nevus dan melanoma. Metodologi. Penelitian ini merupakan penelitian deskriptif observasional dengan desain serial kasus sejak 1 Januari 2015 sampai 30 Desember 2019. Sebanyak 60 sampel dilakukan pemeriksaan imunohistokimia menggunakan antibodi p15. Ekspresi p15 dinilai berdasarkan proporsi sel tumor yang terpulas dan intensitas pulasan. Analisis statistik menggunakan SPSS versi 23.0. Hasil. Nevus melanositik paling banyak dijumpai pada perempuan (76,7%), pada kelompok usia <55 tahun (90%), lokasi tumor pada kepala dan leher (83,3) dan pada tipe histopatologi dermal naevus (53,3%). Melanoma maligna paling banyak ditemukan pada jenis kelamin laki-laki (53,6%), pada kelompok usia <55 tahun (57,1%), lokasi tumor pada kepala dan leher (35,7%) dan pada tipe histopatologi nodular melanoma (42,9%). Terdapat hubungan bermakna antara tingkat ekspresi p15 dengan lesi melanositik (nevus melanositik dan melanoma maligna) (r=0,9666; p=0,000). Kesimpulan. Ekspresi p15 tinggi dijumpai pada nevus melanositik dan rendah pada melanoma maligna. Terdapat hubungan bermakna antara tingkat ekspresi p15 dengan lesi melanositik (nevus melanositik dan melanoma maligna). Semakin rendah ekspresi p15 maka semakin besar kemungkinan terjadi melanoma maligna.

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Naevoid Malignant Melanoma: A Diagnosis of a Naevus That You Later Regret

Cited by 9 publications

References 3 publications

Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma

Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma

Nevoid melanoma: a rare and intriguing variant presenting as polypoidal mass on leg

Hubungan Tingkat Ekspresi P15 Terhadap Nevus Melanositik Dan Melanoma Maligna

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