Naevi and other Developmental Defects

Moss, Celia; Shahidullah, Hossain

doi:10.1002/9781444317633.ch18

Cited by 45 publications

(86 citation statements)

References 1,772 publications

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“…Th ey can can also be diff ered from infl ammatory linear verrucous epidermal nevus (ILVEN) and child nevus, which occur at or soon after birth and usually persist lifelong, However, LS is considered to have a greater affi nity to BL than any other condition. Some authors propose "adult Blaschkitis" a remitting and relapsing eruption of itchy infl ammatory vesicles and papules occurring usually on the trunk in adults and adult version of LS to be the same entity (14,15), while the others think BLAISE should perhaps be considered a description rather than a diagnosis (13).…”

Section: Abbreviationsmentioning

confidence: 99%

“…Probably, they all refl ect genetic mosaicism, the former for multifactorial dermatoses with an autosomal dominant component, and the latter for potentially lethal dominant mutations rescued by mosaicism (13). Th ey can can also be diff ered from infl ammatory linear verrucous epidermal nevus (ILVEN) and child nevus, which occur at or soon after birth and usually persist lifelong, However, LS is considered to have a greater affi nity to BL than any other condition.…”

Section: Abbreviationsmentioning

confidence: 99%

“…Several (13). Probably, they all refl ect genetic mosaicism, the former for multifactorial dermatoses with an autosomal dominant component, and the latter for potentially lethal dominant mutations rescued by mosaicism (13).…”

Section: Abbreviationsmentioning

confidence: 99%

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Cryotherapy for Lichen Striatus in an Adult – a Case Report

Stojanović¹,

Jovanović²,

Vuckovic³

2015

Serbian Journal of Dermatology and Venereology

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Lichen striatus (linear lichenoid dermatosis) is an uncommon, self-limited, inflammatory, linear skin condition of unknown origin. The causes of linear distribution are unknown, though the pattern of lichen striatus (LS) mostly follows the lines of Blaschko (BL). The condition most commonly occurs in children between 5 and 15 years of age, usually after the first year of life. We report a 27-year-old, otherwise healthy flight attendant with LS whose diagnosis was based on: the history of sudden appearance and rapid linear spread of lesions; clinical presentation of small pink, coalescing scaly papules without umbilication or Wickham’s striae, linear distribution following one BL down a lower limb to the ankle, with a band broadening into plaque on the left buttock; histology showed some hyperkeratosis, lichenoid dermatitis similar to lichen planus, but with the presence of inflammatory infiltrate in the papillary dermis and also deeper in the perifollicular region. The inflammatory infiltrate consisted mainly of limphocytes, with some melanophages and histiocytes. There is no standard treatment for LS, and it is given for cosmetic or psychological reasons only, as we have done in our patient due to slight pruritus and occupational reasons. With regard to her occupational demands, in order to achieve satisfying results, she was successfully treated with cryotherapy, which she tolerated well, without any side effects. Cryotherapy was performed twice, with a two-week interval. Full resolution was achieved twelve weeks after cryotherapy. In conclusion, we present an adult female who developed lichen striatus suddenly three months after delivery and was successfully treated with cryotherapy.

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Section: Abbreviationsmentioning

confidence: 99%

Section: Abbreviationsmentioning

confidence: 99%

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Cryotherapy for Lichen Striatus in an Adult – a Case Report

Stojanović¹,

Jovanović²,

Vuckovic³

2015

Serbian Journal of Dermatology and Venereology

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“…nevus, atrophoderma of Moulin, 'blaschkitis'), and epidermal nevus syndrome (3). Since more research has been recently conducted in order to clarify the molecular basis of certain epidermal nevi, it has been suggested that probably all epidermal nevi comprise an abnormal clone of cells, as a consequence of genetic mosaicism arising from a somatic mutation (3,4).…”

mentioning

confidence: 99%

“…Since more research has been recently conducted in order to clarify the molecular basis of certain epidermal nevi, it has been suggested that probably all epidermal nevi comprise an abnormal clone of cells, as a consequence of genetic mosaicism arising from a somatic mutation (3,4). By using molecular techniques for the identifi cation and classifi cation of molecular causes of certain epidermal nevi, all verrucous epidermal nevi are divided into epidermolytic and non-epidermolytic types.…”

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confidence: 99%

Treatment of Verrucous Epidermal Nevus by Radiofrequency Ablation: a Case Report

Ljubisavljević

Zlatanović

Milenkovic

et al. 2015

Serbian Journal of Dermatology and Venereology

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Verrucous epidermal nevi are noninfl ammatory, congenital, cutaneous hamartomas composed of keratinocytes, abnormal clone(s) of cells that refl ect genetic mosaicism arising from different somatic mutations. Some of these mutations are well recognized, but some are still unidentifi ed. Molecular techniques are used for identifi cation and classifi cation of molecular causes of certain epidermal nevi, whereas all verrucous epidermal nevi are divided into epidermolytic and non-epidermolytic types. They are typically present at birth, but may appear during childhood, even later. Their prevalence in adults ranges from 0.1 to 0.5%, equally affecting both sexes, and about 1 in 1000 newborns. Warty, brown papules without infl ammation distinguish verrucous nevi from other epidermal nevi, while presence at birth and persistance distinguish verrucous epidermal nevi from linear viral warts. Epidermolytic and non-epidermolytic verrucous epidermal nevi are almost always hard to distinguish, except by histology. As a rule, verrucous epidermal nevi are asymptomatic, they have a benign course, except occasionally, and therapy is mostly used for cosmetic reasons. Simple excision is usually the treatment of choice. Topical agents are rarely curative, as well as surgery which is associated with relapses, unless both epidermis and the underlying dermis are removed or destroyed at the same time. We present a case of an otherwise healthy 21-year-old female patient, who presented with a solitary congenital verrucous caulifl ower-like lesion in the right zygomatic region of the face. The lesion was present from birth. Due to its gradual growth during years, the lesion became a great esthetic and functional problem for this young patient. There was no family history of similar or any other tumorous skin lesions in the family. On examination, the patient had a solitar unilateral, well defi ned yellowish caulifl ower-like verrucous lesion confi ned to the right malar side of the face. The lesion was distributed along the lines of Blaschko extending horizontally, from its wider 1.5 cm caulifl ower-like part on the right zygomatic region, towards its tail-like 0.5 cm thick end on the preauricular region, in approximately 3 cm long tail-like manner without crossing the midline. Since the patient refused biopsy, no exact differentiation between epidermolytic and non-epidermolytic nevi was possible. The diagnosis of verrucous epidermal nevus was based on history and clinical presentation, as a diagnosis of exclusion. Due to the fact that patients with epidermolytic verrucous epidermal nevi are at risk of parenting a child with bullous ichthyosiform erythroderma, the patient was counseled on this risk, and on the possibility of fi rst-trimester antenatal diagnosis. The lesion was successfully treated by radio-wave surgery.

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