Nadwrażliwość na leki znieczulenia miejscowego

Grzanka, Alicja; Wasilewska, Iwona; Śliwczyńska, Magdalena; Misiołek, Hanna

doi:10.5603/ait.a2016.0017

Cited by 17 publications

(10 citation statements)

References 24 publications

(39 reference statements)

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“…First of all, allergic reaction to local anesthetic is very rare, with a rate of occurrence of less than 1% [ 1 ]. Allergic reaction to local anesthetic involves two major types: IgE-mediated type I and T-cell-mediated type IV reactions [ 8 9 10 ]. Type I reaction occurs as a result of the release of mediators, such as histamine from mast cells and basophils, which leads to the binding of IgE antibodies to antigens [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Type I and IV reactions occur mostly in association with ester-type anesthetics. This is because para-aminobenzoic acid (PABA), a metabolite of the ester group, possesses strong allergenic potential [ 8 ]. Methyl-paraben and propylparaben, widely used as preservatives of local anesthetics, can also induce allergic reactions as a result of their metabolism, which produces compounds similar to PABA [ 3 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…For patients who have a history of allergy to local anesthetics, careful and thorough history taking regarding the history of allergies is important, and allergy tests, such as skin prick and/or intradermal tests become mandatory [ 8 ]. In subsequent treatments, local anesthetics to which the patient had tested negative in the allergy tests should be used, and when such an option is unavailable, treatment under general anesthesia should be considered.…”

Section: Discussionmentioning

confidence: 99%

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Dental anesthesia for patients with allergic reactions to lidocaine: two case reports

Lee

Kim

et al. 2016

J Dent Anesth Pain Med

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Lidocaine, a local anesthetic commonly used in dental treatments, is capable of causing allergies or adverse effects similar to allergic reactions. However, the frequency of such occurrences in actual clinical settings is very rare, and even clinical tests on patients with known allergies to local anesthetics may often show negative results. When adverse effects, such as allergy to lidocaine, are involved, patients can be treated by testing other local anesthetics and choosing a local anesthetic without any adverse effects, or by performing dental treatment under general anesthesia in cases in which no local anesthetic without adverse effects is available. Along with a literature review, the authors of the present study report on two cases of patients who tested positive on allergy skin tests for lidocaine and bupivacaine and subsequently underwent successful dental treatments with either general anesthesia or a different local anesthetic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dental anesthesia for patients with allergic reactions to lidocaine: two case reports

Lee

Kim

et al. 2016

J Dent Anesth Pain Med

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“…In the older literature local anesthetics are sometimes mentioned as potential MC activators through IgE and non-IgE dependent reactions [47]. Up to 3% of cases in the general population experience adverse reactions after local anesthesia [48,49]. Most, if not all, of these reactions are vasovagal in nature, whereas real allergic reactions seem to be rare (<1% of all adverse events).…”

Section: Local Anestheticsmentioning

confidence: 99%

A Challenge for Allergologist: Application of Allergy Diagnostic Methods in Mast Cell Disorders

Romantowski

Górska

Niedoszytko

et al. 2021

IJMS

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Primary and secondary mast cell activation syndromes (MCAS) can occur in patients with mastocytosis. During the past few years our knowledge about the pathogenesis and disease-triggering mechanisms in MCAS and mastocytosis have increased substantially. Whereas mastocytosis is characterized by an accumulation of neoplastic (clonal) mast cells (MC) in various organ systems, MCAS is defined by a massive and systemic activation of these cells. Mast cells are crucial effector cells in allergic diseases, thus their elevated number and activation can cause severe anaphylactic reactions and MCAS in patients with mastocytosis. However, these cells may also degranulate spontaneously or degranulate in response to non-allergic triggers leading to clinical symptoms. In mastocytosis patients, such symptoms may lead to the diagnosis of a primary MCAS. The diagnosis of a concomitant allergy in mastocytosis patients is challenging. In these patients, a mixed form (primary and secondary) of MCAS may be diagnosed. These patients may also suffer from life-threatening anaphylactic reactions when exposed to allergens. In these cases, the possibility of severe side effects of in vivo provocations can sometimes also limit diagnostic evaluations. In the current article, we discuss the diagnosis and management of patients suffering from mastocytosis and concomitant MCAS, with special emphasis on novel diagnostic tests and management, including allergen microarrays, recombinant allergen analysis, basophil activation tests, optimal prophylaxis, and specific therapies.

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“…The incidence of true IgE-mediated LA allergy remains unclear and is presumed to be as low as 0.7-1%. On some occasions these reactions have been attributed to preservatives (methylparaben) or antioxidants (bisulfites) that are contained in some commercial presentations [63,64]. When someone is reactive to a LA, they will be allergic to it for the rest of their life due to the response of mast cells that release chemical mediators that are responsible for the clinical responses in each patient.…”

Section: Allergiesmentioning

confidence: 99%

Local Anesthetics

Whizar-Lugo¹,

Íñiguez-López²,

Cárdenas-Maytorena³

et al. 2020

Topics in Local Anesthetics

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The fascinating history of local anesthetics (LAs) began in South America with the herbal and traditional use of cocaine leaves by the indigenous peoples of Peru and Bolivia, the sacred plant of the Incas Erythroxylum coca. The use for anesthetic purposes dates back to 1884. Since then, the evolution of LAs has been closely related to research motivated by its efficacy and safety versus toxicity. According to their chemical structure, these drugs are classified into two main groups: esters and amino amides; however, there are three LAs with different characteristics: articaine, sameridine, and centbucridine. The pharmacological and toxic mode of action is primarily in the voltage-dependent sodium channels located in the cell membrane, which clinically produces analgesia, anesthesia, seizures, arrhythmias, and cardiac arrest. The quality of anesthesia and analgesia depends on the type of LA, dose, and application technique, while the deleterious effects are secondary to its plasma concentration. Nonanesthetic properties of LAs such as their antimicrobial, antineoplastic, antiarrhythmics, antitussive, and antiasthmatics effects have been described and are briefly reviewed.

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Nadwrażliwość na leki znieczulenia miejscowego

Cited by 17 publications

References 24 publications

Dental anesthesia for patients with allergic reactions to lidocaine: two case reports

Dental anesthesia for patients with allergic reactions to lidocaine: two case reports

A Challenge for Allergologist: Application of Allergy Diagnostic Methods in Mast Cell Disorders

Local Anesthetics

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