Abstract:Due to the role that oxidative stress plays in the pathophysiology of type 2 diabetes (T2D), polymorphic genes that encode enzymes producing reactive oxygen species represent attractive targets for genetic disease susceptibility testing. This pilot study investigated whether single nucleotide polymorphisms (SNP) in the NOX5 gene (NADPH oxidase 5) are associated with the risk of type 2 diabetes. A total of 1579 T2D patients and 1627 age- and sex-matched healthy subjects were recruited for this study. Genotyping… Show more
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