NADPH diaphorase neurones are evenly distributed throughout cat neocortex irrespective of functional specialization of each region

Kuchiiwa, Satoshi; Kuchiiwa, Toshiko; Mori, Satoshi; Nakagawa, Shiro

doi:10.1097/00001756-199408150-00030

Cited by 23 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Morphology, size, and staining of ND-expressing neurons show a degree of variations reflecting the existence of distinct types of heavily or weakly stained neurons. The presence of such a variability in the characteristics of ND neurons is a constant feature for the cells identified by this neurochemical marker, both in mammals, including man (Vincent and Kimura 1992;Fischer and Kuljis 1994;Kuchiiwa et al 1994;Tomimoto et al 1994), and in galliform birds (Brüning 1993;Panzica et al 1994a). There is no actual evidence that such morphological subdivisions might reflect also physiological differences of the ND-expressing neurons.…”

Section: Discussionmentioning

confidence: 95%

The NADPH-diaphorase-containing system in the brain of the budgerigar ( Melopsittacus undulatus )

Cozzi

Massa

Panzica

1996

Cell and Tissue Research

View full text Add to dashboard Cite

In the present investigation we studied the presence and distribution of histochemically detected neuronal NADPH-diaphorase (ND) in the brain of the budgerigar, Melopsittacus undulatus. Positive neurons are widely distributed throughout the central nervous system. ND-containing neurons are present in the telencephalon and the paleostriatal-parolfactory lobe complex. Positive cells were observed also in the neostriatum, including the main auditory area (field L), in several nuclei of the archistriatum and in the hyperstriatum (accessory, dorsal, and ventral). In the diencephalon, positive neurons were present both in the lateral hypothalamic and periventricular areas, and in a segregate area at the confluence of the anterior commissure and the lateral prosencephalic bundle. A group of positive perikarya was located lateral to the dorsal part of the IIIrd ventricle, and continued laterally into the thalamus. Weakly stained neurons were observed in the thalamic dorsomedial posterior nucleus. In the mesencephalon, ND-containing neurons were scattered in the reticular formation (pars lateralis and pars medialis) and in the optic tecta. A large population of positive neurons was observed in the substantia nigra, the ventral area of Tsai and the nucleus interpeduncularis. Positive neurons extended through the tegmental nuclei to the locus coeruleus. In the cerebellum, the granular neurons were weakly stained and the internal cerebellar nuclei were surrounded by a wide network of positive fibers. In the medulla the number of positive cells was highly reduced, but stained neurons were observed in the cochlear as well in the vestibular nuclei. The data here presented suggest that the distribution of ND-containing neurons in the brain of the budgerigar is different from those of the chicken and quail. The locations of positive neurons suggest also a possible involvement in sound perception and production pathways, and visual perception.

show abstract

Section: Discussionmentioning

confidence: 95%

The NADPH-diaphorase-containing system in the brain of the budgerigar ( Melopsittacus undulatus )

Cozzi

Massa

Panzica

1996

Cell and Tissue Research

View full text Add to dashboard Cite

show abstract

“…in layers V and VI of the frontal cortex) (Vincent & Kimura, 1992;Rodrigo et al, 1994). In the cat neocortex, NOS neurones appear to be evenly distributed throughout the cortical layers irrespective of functional specialization of each region (Kuchiiwa et al, 1994). In monkeys, some unique fibre patterns have been observed in, e.g.…”

Section: Cortexmentioning

confidence: 99%

Histochemistry of nitric oxide synthase in the nervous system

1995

View full text Add to dashboard Cite

Nitric oxide synthase, which generates the physiological messenger molecule nitric oxide, and its associated NADPH diaphorase (NADPHd) activity are distributed throughout selective neuronal populations of the central and peripheral nervous system. Considerable evidence has been accumulated to indicate that NADPHd activity labels cells lacking neuronal nitric oxide synthase, i.e., the specificity of the reaction has to be considered for the reliable detection of the enzyme in neuronal but also non-neuronal tissue. In the present review, critical aspects of nitric oxide synthase visualization in neurones, using its NADPHd activity, are discussed. Furthermore, the organization of the central and peripheral nitric oxide synthase-containing neuronal systems is described. Nitric oxide synthase is present in local cortical and striatal neurones, hypothalamic magnocellular neurones, mesopontine cholinergic neurones, cerebellar interneurones, preganglionic sympathetic and parasympathetic neurones, neurones in parasympathetic autonomic and enteric ganglia and primary viscero-afferent neurones. Finally, injury-related alterations in nitric oxide synthase activity are briefly outlined. In this respect, the histochemistry of nitric oxide synthase may represent a valuable marker for neurochemical, if not structural, alterations observed in neural diseases, regeneration and transplantation.

show abstract

“…Recently, it has been found that diaphorase-positive neurons are present in the cortical SP of mammals, suggesting a possible role for NO in regulating the formation of cortical connectivity (Yan et al 1996a;Downen et al 1999;Judas et al 1999). Nitridergic neurons are also distributed across mature cortical areas, in man as well as in subhuman species (Yan et al 1994(Yan et al , 1996aKuchiiwa et al 1994;Riche et al 1995;Xiao et al 1996;Yan and Garey 1997;Judas et al 1999;Barone and Kennedy 2000). In these reports, the authors have basically described two types of diaphorase-positive neurons: type I or heavily labeled neurons, and type II or lightly labeled cells.…”

Section: Introductionmentioning

confidence: 99%

“…They have described the laminar distribution of nitridergic cells, which tend to predominate in the cortical deep layers/white matter of adults. More recently, at least two studies have shown that the distribution of nitridergic cells is inhomogeneous across cortical areas (Bidmon et al 1997; Barone and Kennedy 2000; but see Kuchiiwa et al 1994;Garey 1997, Judas et al 1999). Therefore, each area would have its unique nitridergic cell profile.…”

Section: Introductionmentioning

confidence: 99%

“…In the cerebral cortex, the developmental timetable of appearance and distribution of diaphorase-positive cells has revealed variability according to species and a general trend for SP neurons to precede those in the cortical plate (Yan et al 1996b;Downen et al 1999;Judas et al 1999). In the CgC of both human and non-human mammals, the studies concerning nitridergic neurons are limited to brief mentions about their presence in the mature brain (Vincent and Kimura 1992;Kuchiiwa et al 1994;Bidmon et al 1997), with no details on either morphological types or laminar distribution.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diaphorase-positive neurons in the cingulate cortex of human fetuses during the second half of gestation

deAzevedo

Hedin-Pereira²,

Lent

2002

Anatomy and Embryology

View full text Add to dashboard Cite

In this work, the time course of appearance, distribution and morphology of diaphorase-positive neurons were studied in the developing cingulate cortex of the human brain during the second half of gestation. Five human fetuses at 18, 20, 25, 30 and 35 weeks postovulatory (wpo) were examined. The brain tissue was reacted by an indirect histochemistry protocol for detection of NADPH-diaphorase activity. Labeled neurons were identified at the microscope and documented photographically or by computer-aided charts. We have found that heavily labeled neurons (type I) first appear in the subplate (SP) between 20 and 25 wpo, and in the cortical plate (CP) between 25 and 35 wpo. By 35 wpo, CP neurons were both type I and type II (lightly labeled neurons). In addition, we observed 4 different morphological types among subplate neurons, very similar to callosally-projecting subplate cells (as described previously by our group). We concluded that medial nitridergic neurons of humans appear prenatally according to the usual gradient of cortical maturation -- first in the subplate and later in the cortical plate. Also, we suggest that some of the diaphorase-positive neurons in the transient subplate could possibly be callosal.

show abstract

NADPH diaphorase neurones are evenly distributed throughout cat neocortex irrespective of functional specialization of each region

Cited by 23 publications

References 0 publications

The NADPH-diaphorase-containing system in the brain of the budgerigar ( Melopsittacus undulatus )

The NADPH-diaphorase-containing system in the brain of the budgerigar ( Melopsittacus undulatus )

Histochemistry of nitric oxide synthase in the nervous system

Diaphorase-positive neurons in the cingulate cortex of human fetuses during the second half of gestation

Contact Info

Product

Resources

About