NADPH diaphorase neuronal dystrophy in gracile nucleus, cuneatus nucleus and spinal trigeminal nucleus in aged rat

Hou, Wei; Jia, Yunge; Li, Yinhua; Wei, Zichun; Wen, Xiaoxin; Rao, Chenxu; Xu, Xiuhua; Li, Fuhong; Wu, Xiu-Ping; Sun, Hongbin; Li, Hang; Huang, Yizhe; Sun, Jui-Hung; Shu, Gege; Wang, Xinghang; Zhang, Tianyi; Shi, Geming; Guo, Anchen; Xu, Shengfei; Du, Guangsheng; Tan, Huibing

doi:10.1101/2019.12.21.885988

Cited by 3 publications

(3 citation statements)

References 103 publications

(112 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 Within a few months of spinal cord injury, NADPHdiphosphorase abnormality is seen in the nucleus cuneatus, nucleus gracilis, and spinal trigeminal tract of rats. 32 Neuropathic pain may be experienced by about 80% of individuals who sustain spinal cord injury. 22,56,57 Some studies have pointed out the role of dorsal root ganglion in neuropathic pain.…”

Section: Discussionmentioning

confidence: 99%

Cervical Discopathy in Idiopathic Trigeminal Neuralgia: More than Coincidence?

Börü

Bölük²,

Özdemır

et al. 2021

Egyptian Spine Journal

View full text Add to dashboard Cite

Background Data: The most common cause of trigeminal neuralgia is neurovascular compression. However, several patients present with unknown etiology. Purpose: This study aims to investigate the relationship between trigeminal neuralgia and cervical pathology in patients previously diagnosed with idiopathic trigeminal neuralgia. Study Design: We designed an observational case-control study in our tertiary center. Patients and Methods: A study group consisting of patients previously diagnosed with idiopathic trigeminal neuralgia and a control group consisting of patients with tension-type headaches were included in the study. A blinded neuroradiologist reevaluated cranial MRIs of trigeminal neuralgia patients. Once it was confirmed that no signs of neurovascular compression or any secondary causes were present, a cervical MRI was performed to evaluate cervical pathologies. Cranial and cervical MRIs of the controls were evaluated by the same neuroradiologist. Results: Twenty patients who had prior diagnoses of idiopathic trigeminal neuralgia and 20 controls were investigated. The mean age of trigeminal neuralgia patients was 64.9 ± 12.6, and the mean age of the control group was 61.3 ± 9.1 (p = 0.305). The male/female ratio in trigeminal neuralgia patients was 2.3 and 1.8 in the control group (p = 0.736). While indentation on the trigeminal spinal tract above the C4 spinal level was observed in 12 out of 20 patients, none of the controls had any involvement in the same region (p < 0.001).

show abstract

Section: Discussionmentioning

confidence: 99%

Cervical Discopathy in Idiopathic Trigeminal Neuralgia: More than Coincidence?

Börü

Bölük²,

Özdemır

et al. 2021

Egyptian Spine Journal

View full text Add to dashboard Cite

show abstract

“…It has been reported that any pathology in the spinal cord may cause hyperexcitability in the dorsal horn. [25,26] This might occur through dysregulation of glutamate release, uptake and receptor expression, [25,[27][28][29] dendritic spine remodeling, [30,31] loss of local inhibitory (GABAergic) tone, [32][33][34][35][36] descending (particularly serotonergic) inhibitory input to spinal nociceptive circuitry, [28,39,40] or increased expression of calcium channel subunit. [39] Within a few months of spinal cord injury, NADPH-diphosphorase abnormality is seen in the nucleus cunaetus, nucleus gracilis, and spinal trigeminal tract of rats.…”

Section: Discussionmentioning

confidence: 99%

“…[39] Within a few months of spinal cord injury, NADPH-diphosphorase abnormality is seen in the nucleus cunaetus, nucleus gracilis, and spinal trigeminal tract of rats. [40] Neuropathic pain may be experienced by about 80% of individuals who sustain spinal cord injury. [41][42][43] Some studies have pointed out the role of dorsal root ganglion in neuropathic pain.…”

Section: Discussionmentioning

confidence: 99%

Cervical Discopathy in Idiopathic Trigeminal Neuralgia: More than Coincidence?

Börü

Bölük

Özdemır

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundThe most common cause of trigeminal neuralgia (TN) is neurovascular compression. However, a number of patients present with unknown etiology. This study aims to investigate the relationship between TN and cervical pathology in patients previously diagnosed with idiopathic TN. MethodsWe designed an observational case-control study. A study group consisting of patients previously diagnosed with idiopathic TN and a control group was included in the study. Cranial MRI’s of TN patients were re-evaluated by a blinded neuroradiologist. Once it was confirmed that no signs of neurovascular compression or any secondary causes were present, a cervical MRI was performed to evaluate cervical pathologies. Results20 patients and 20 controls were investigated. The mean age of TN patients was 64.9±12.6, and the mean age of the control group was 61.3±9.1 (p=0.305). Whilst indentation on the trigeminal spinal tract above C4 spinal level was observed in 12 out of 20 patients, none of the controls had any involvement in the same region (p<0.001). ConclusionsThe results of this study suggest that extramedullary indentation on the trigeminal spinal tract caused by upper cervical discopathy may be one of the possible etiological factors in TN.

show abstract

A pathway of NADPH diaphorase positivity between central canal and pial surface at anterior fissure in spinal cord: Supra fissure area with hypothesis configuring from dog, rat, monkey and pigeon

Jia

Hou

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

The spinal cord is a cylinder structure in the vertebra and thought a simplified with the gray matter and white matter. Rexed lamination for the gray matter and regional sub-division for whiter matter are completely termed to date. Anterior commissure locates between the central canal and the anterior median fissure. However, some experimental data may still confront with new confined anatomical interpretation. By using NADPH diaphorase [N-d] enzyme histology, we found a vertical oriented neuronal pathway between the central canal and the anterior median fissure in the sacral spinal cord of young adult and aged dog. We used a term "supra fissure area" [SFA] to illustrate the region which consisted of the gray commissure and anterior white commissure. The N-d pathway was notably observable in aged animals. The vertical neurites revealed the cerebrospinal fluid [CSF] contacting neurites between the anterior median fissure and the central canal. We further examined the monkey, rat and pigeon in the region for better understanding of the structure and potential function. The neurodegeneration of N-d dystrophy was detected in the [SFA] in the thoracic spinal cord of the aged monkey. N-d positive fibers were detected in anterior fissure of the rat spinal cord. N-d fibrous structures were also detected in the pigeon spinal cord. These results suggested a new pathway of CSF contacting neurons and the neuronal communications about the central canal.

show abstract

NADPH diaphorase neuronal dystrophy in gracile nucleus, cuneatus nucleus and spinal trigeminal nucleus in aged rat

Cited by 3 publications

References 103 publications

Cervical Discopathy in Idiopathic Trigeminal Neuralgia: More than Coincidence?

Cervical Discopathy in Idiopathic Trigeminal Neuralgia: More than Coincidence?

Cervical Discopathy in Idiopathic Trigeminal Neuralgia: More than Coincidence?

A pathway of NADPH diaphorase positivity between central canal and pial surface at anterior fissure in spinal cord: Supra fissure area with hypothesis configuring from dog, rat, monkey and pigeon

Contact Info

Product

Resources

About