NADPH-diaphorase histochemistry reveals an autonomic-like innervation in the postnatal hamster cochlea

Morris, John-Clay K.; Phelps, Patricia E.; Simmons, Dwayne D.

doi:10.1002/(sici)1096-9861(19990927)412:3<458::aid-cne6>3.0.co;2-f

Cited by 1 publication

(2 citation statements)

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“…An electron microscopical study conducted by the same group (Heinrich et al, 1997) yielded similar results. However, neither in the studies conducted by Fessenden and co-workers (Fessenden et al, 1994(Fessenden et al, , 1999Fessenden and Schacht, 1998) and in a recent diaphorase study (Morris et al, 1999) nor in our own investigations (Riemann and Reuss, 1999a) were hair cells of any type seen to exhibit nNOS-immunoreaction. It is likely that these differences are due to inadequate specificity of some of the nNOS antisera.…”

Section: Neuronal Nitric Oxide Synthase Incontrasting

confidence: 68%

“…The situation may be different, however, during development. The presence of putatively autonomic fibers stained by the NADPH-d method were found at early postnatal days in the hamster, accompanied by the presence of stained neurons in the SCG and the absence of such cells in the SOC (Morris et al, 1999). Whether NO is indeed produced by SCG and whether this is also supplied to the cochlea must be left open for further investigation.…”

Section: Further Structures Related To Auditory Processing That Contain Nosmentioning

confidence: 99%

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Distribution and projections of nitric oxide synthase neurons in the rodent superior olivary complex

Reuss

Riemann

2000

Microsc. Res. Tech.

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The superior olivary complex (SOC), a group of interrelated brainstem nuclei, sends efferents to a variety of neuronal structures including the cochlea and the inferior colliculus. The present review describes data obtained from rodents providing evidence that the gaseous, short-living neuroactive substance nitric oxide (NO) is produced in the SOC. The NO-synthesizing enzyme neuronal NO-synthase (nNOS) has been localized by means of several methods including histochemistry and immunohistochemistry. Perikarya containing nNOS were found in several nuclei of the SOC. Their largest numbers and percentages of total cells were observed in the medial nucleus of the trapezoid body. Stained terminals were observed mainly in the lateral superior olivary nucleus and in the superior paraolivary nucleus. While retrograde neuronal tracing identified a considerable number of nNOS-immunoreactive neurons as to be part of the olivo-cochlear pathway, the projection patterns of other nNOS-immunoreactive SOC cell groups remain to be investigated. We also review other putative sources of cochlear NO, and discuss the possible role of NO in the lower auditory brainstem and organ of Corti with regard to physiological and pathophysiological mechanisms.

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Section: Neuronal Nitric Oxide Synthase Incontrasting

confidence: 68%

Section: Further Structures Related To Auditory Processing That Contain Nosmentioning

confidence: 99%

Distribution and projections of nitric oxide synthase neurons in the rodent superior olivary complex

Reuss

Riemann

2000

Microsc. Res. Tech.

View full text Add to dashboard Cite

show abstract

NADPH-diaphorase histochemistry reveals an autonomic-like innervation in the postnatal hamster cochlea

Cited by 1 publication

References 56 publications

Distribution and projections of nitric oxide synthase neurons in the rodent superior olivary complex

Distribution and projections of nitric oxide synthase neurons in the rodent superior olivary complex

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