NAD+ salvage governs the immunosuppressive capacity of mesenchymal stem cells

Fang, Jiankai; Hou, Pengbo; Liu, Shisong; Zuo, Muqiu; Liu, Zhanhong; Chen, Wangwang; Han, Yuyi; Li, Yanan; Wang, Tingting; Feng, Chao; Li, Peishan; Shao, Changshun; Shi, Yufang

doi:10.1038/s41423-023-01073-2

Cited by 5 publications

(2 citation statements)

References 65 publications

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“… 3 , 40 , 41 Several studies have also identified NAD+ metabolism as the basis of immunomodulatory functions in MSCs and found that nicotinamide-phosphate ribosyltransferase (NAMPT)-mediated NAD+ metabolism activates and maintains the aerobic glycolytic program in the cytoplasm through driving the succinate-hypoxia-inducible factor 1-alpha (HIF1α) axis in the mitochondria, which in turn shapes the immunosuppressive function of MSCs and exerts an important therapeutic impact on disease. 42 In ESCs, mitochondria are in a “hyperactive” state, characterized by efficient ATP production; OXPHOS can couple the amino-hexose synthesis pathway to regulate the self-renewal and multidirectional differentiation potential of PSCs via aminoacyl glycosylation by pluripotency factors. 43 In addition, the nuclear localization of pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1), a TCA cycle enzyme in PSCs, promotes the direct synthesis of acetyl-coenzyme A in the nucleus, which provides a reaction substrate for histone acetylation.…”

Section: Processes Affecting Metabolic Homeostasis In Stem Cellsmentioning

confidence: 99%

Molecular mechanisms of cellular metabolic homeostasis in stem cells

Li,

Jiang,

Wang

2023

Int J Oral Sci

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Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.

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Section: Processes Affecting Metabolic Homeostasis In Stem Cellsmentioning

confidence: 99%

Molecular mechanisms of cellular metabolic homeostasis in stem cells

Li,

Jiang,

Wang

2023

Int J Oral Sci

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“…Mesenchymal stem cells have been reported in earlier research studies to have rejuvenating and restorative properties in a variety of diseases [ 7 , 8 , 9 ], including but not limited to, repairing of cartilages in osteoarthritis [ 10 ], remodeling and restoration of the performances of the myocardial-infarcted hearts [ 11 ], and chronic atrophic gastritis [ 12 ] etc. Furthermore, on the global scale, clinical trials exploring the effectiveness of mesenchymal stem cells in management of the ailments have been presently underway, with a focus on autoimmune disorders [ 13 , 14 ], Crohn’s disease [ 15 ], grafts versus host diseases [ 16 , 17 ], multiple sclerosis [ 18 ], systemic lupus erythematosus [ 19 , 20 ], and systemic sclerosis [ 21 , 22 ] etc.…”

Section: Introductionmentioning

confidence: 99%

Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered Nanocarriers in Targeted Nanotherapeutics

Baig,

Ahmad,

Pathan

et al. 2024

JoX

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In the recent past, the formulation and development of nanocarriers has been elaborated into the broader fields and opened various avenues in their preclinical and clinical applications. In particular, the cellular membrane-based nanoformulations have been formulated to surpass and surmount the limitations and restrictions associated with naïve or free forms of therapeutic compounds and circumvent various physicochemical and immunological barriers including but not limited to systemic barriers, microenvironmental roadblocks, and other cellular or subcellular hinderances—which are quite heterogeneous throughout the diseases and patient cohorts. These limitations in drug delivery have been overcome through mesenchymal cells membrane-based precision therapeutics, where these interventions have led to the significant enhancements in therapeutic efficacies. However, the formulation and development of nanocarriers still focuses on optimization of drug delivery paradigms with a one-size-fits-all resolutions. As mesenchymal stem cell membrane-based nanocarriers have been engineered in highly diversified fashions, these are being optimized for delivering the drug payloads in more and better personalized modes, entering the arena of precision as well as personalized nanomedicine. In this Review, we have included some of the advanced nanocarriers which have been designed and been utilized in both the non-personalized as well as precision applicability which can be employed for the improvements in precision nanotherapeutics. In the present report, authors have focused on various other aspects of the advancements in stem cells membrane-based nanoparticle conceptions which can surmount several roadblocks and barriers in drug delivery and nanomedicine. It has been suggested that well-informed designing of these nanocarriers will lead to appreciable improvements in the therapeutic efficacy in therapeutic payload delivery applications. These approaches will also enable the tailored and customized designs of MSC-based nanocarriers for personalized therapeutic applications, and finally amending the patient outcomes.

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SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation

Li,

Wang,

et al. 2024

Molecular Therapy

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NAD+ salvage governs the immunosuppressive capacity of mesenchymal stem cells

Cited by 5 publications

References 65 publications

Molecular mechanisms of cellular metabolic homeostasis in stem cells

Molecular mechanisms of cellular metabolic homeostasis in stem cells

Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered Nanocarriers in Targeted Nanotherapeutics

SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation

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