NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations

Gaedigk, Andrea; Tyndale, Rachel F.; Jurima-Romet, Malle; Sellers, Edward M.; Dm, Grant; Js, Leeder

doi:10.1097/00008571-199808000-00004

Cited by 85 publications

(59 citation statements)

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“…In the coding region of the NQO1 gene, two functional polymorphisms (C609T and C465T) are known. The phenotype implications of the NQO1 C465T polymorphism vary according to substrate, and the frequency of the NQO1 C465T polymorphism in the population is very low [16,17]. The most prevalent variant allele is the NQO1 C609T polymorphism, which has profound implications for the phenotype.…”

Section: Discussionmentioning

confidence: 99%

The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes

Han

Kang

Kim

et al. 2009

Molecular Genetics and Metabolism

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Section: Discussionmentioning

confidence: 99%

The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes

Han

Kang

Kim

et al. 2009

Molecular Genetics and Metabolism

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“…Batzer et al (1994); Stoneking et al (1997); Novick et al (1998); 2. Gaedigk et al (1998) Deka et al (1991Deka et al ( , 1994Deka et al ( , 1999, Deka and Chakraborty (1999); Destro-Bistrol et al (2000); 10. Rangel-Villalobos et al (2000); 11.…”

Section: Other Autosome Markersmentioning

confidence: 99%

Molecular variability in Amerindians: widespread but uneven information

Salzano

2002

An. Acad. Bras. Ciênc.

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A review was made in relation to the molecular variability present in North, Central, and South American Indian populations. It involved results from ancient DNA, mitochondrial DNA in extant populations, HLA and other autosomal markers, X and Y chromosome variation, as well as data from parasitic viruses which could show coevolutionary changes. The questions considered were their origin, ways in which the early colonization of the continent took place, types and levels of the variability which developed, peculiarities of the Amerindian evolutionary processes, and eventual genetic heterogeneity which evolved in different geographical areas. Although much information is already available, it is highly heterogeneous in relation to populations and types of genetic systems investigated. Unfortunately, the present trend of favoring essentially applied research suggest that the situation will not basically improve in the future.

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“…31,32 Further complicating the heterogeneous nature of DTD expression across tissue types is the role of a single -base change, a C -to -T transition in nucleotide 609 of DTD cDNA, conferring a predicted proline -to -serine change in amino acid 187. This base change is frequent in the population 33 and has been associated with reduced catalytic activity, protein instability, and MMC resistance. 15,18,21 One way to address this problem is to introduce a bioreductive enzyme like DTD into tumor cells using gene transfer techniques.…”

Section: Discussionmentioning

confidence: 99%

Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro

2002

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Intratumoral injection of recombinant adenoviral type 5 ( Ad5 ) vectors that carry prodrug -activating enzymes like DT -diaphorase ( DTD ) could be used to selectively target tumor cells for chemotherapy. To demonstrate the feasibility of this approach, Ad5 vectors were constructed, which express human DTD minigenes for both wild -type and mutant ( C -to -T change in nucleotide 609 in DTD cDNA ) DTD under the control of the cytomegalovirus ( CMV ) promoter. HT29 human colon carcinoma cells express wild -type DTD, whereas BE human colon carcinoma cells express mutant DTD, have low to undetectable DTD activity, and are 4 -to 6 -fold more resistant to mitomycin C ( MMC ) than HT29 cells. A test of the ability of Ad5 to infect these cells ( using a -galactosidase CMVdriven minigene ) indicated that 90 -100% of BE cells were infected at a multiplicity of infection ( MOI ) of 100, whereas only 15 -40% of HT29 cells were infected at this MOI. Infection of BE cells in vitro with recombinant Ad5 carrying a minigene for wild -type DTD at MOIs of 3 -100 resulted in a progressive increase in DTD activity and a maximal 8 -fold increase in sensitivity to MMC as measured by a colony -forming assay. HT29 cells were sensitized 2 -to 3 -fold following treatment with Ad5.DTD at an MOI of 100. These results indicate that adenovirus -mediated gene transfer and expression of wild -type DTD can sensitize resistant tumor cells to MMC and that this therapeutic strategy may exert a significant bystander effect.

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NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations

Cited by 85 publications

References 0 publications

The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes

The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes

Molecular variability in Amerindians: widespread but uneven information

Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro

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