NAD+ in Brain Aging and Neurodegenerative Disorders

Lautrup, Sofie; Sinclair, David; Mattson, Mark P.; Fang, Evandro Fei

doi:10.1016/j.cmet.2019.09.001

Cited by 432 publications

(336 citation statements)

References 231 publications

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“…脑细胞线粒体功能障碍、细胞内氧化损伤的大分子(DNA、脂质和蛋白质)堆积、能量代谢失调、细胞"废物处理"机制受损、适应性应激反应受损、DNA修复受损、神经网络活动异常、神经元Ca 2+ 处理异常、干细胞衰竭和炎症, 被誉为大脑老化的10大特征 [75] . NAD + 是参与细胞生物能学、基因组稳定性、线粒体稳态、适应应激反应和细胞存活的关键代谢物, 与大脑老化和神经退行性疾病关系密切 [76] . Sirtuins作为依赖于NAD + 的去酰基化酶,…”

Section: Oa的发展有保护作用 Sirt7在软骨组织中的作用与unclassified

The current progress of histone deacetylase SIRT7

Zhan¹,

Xiong²,

Huang³

et al. 2020

Sci. Sin.-Vitae

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Section: Oa的发展有保护作用 Sirt7在软骨组织中的作用与unclassified

The current progress of histone deacetylase SIRT7

Zhan¹,

Xiong²,

Huang³

et al. 2020

Sci. Sin.-Vitae

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“…The anti-inflammatory effect of NAD + boosting compounds is also extended to diseases affecting the nervous system [82]. Nicotinamide riboside (NR) supplementation reduces microgliosis, astrogliosis and cytokine secretion in a mouse model of AD [83].…”

Section: Nad + Precursorsmentioning

confidence: 99%

Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria

Gabandé‐Rodríguez

Heras

Mittelbrunn

2019

Cells

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Mitochondrial metabolism and autophagy are two of the most metabolically active cellular processes, playing a crucial role in regulating organism longevity. In fact, both mitochondrial dysfunction or autophagy decline compromise cellular homeostasis and induce inflammation. Calorie restriction (CR) is the oldest strategy known to promote healthspan, and a plethora of CR mimetics have been used to emulate its beneficial effects. Herein, we discuss how CR and CR mimetics, by modulating mitochondrial metabolism or autophagic flux, prevent inflammatory processes, protect the intestinal barrier function, and dampen both inflammaging and neuroinflammation. We outline the effects of some compounds classically known as modulators of autophagy and mitochondrial function, such as NAD+ precursors, metformin, spermidine, rapamycin, and resveratrol, on the control of the inflammatory cascade and how these anti-inflammatory properties could be involved in their ability to increase resilience to age-associated diseases.

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“…In this context, an age-dependent decrease in NAD + content occurs in many organisms, that contributes to the development of the age-associated metabolic decline and the development of several age-related diseases [7,9,10]. In addition, it has been shown that supplementation of some NAD + precursors has health benefits and can attenuate certain deficiencies associated with the aging process [11][12][13][14][15]. In this regard, a mini-review has been published [16] based on results of NAD + precursor supplementation, which have been presented by basic researchers and clinicians in a recent meeting (3rd NO-Age Symposium, 2019).…”

Section: Introductionmentioning

confidence: 99%

Nicotinamide, Nicotinamide Riboside and Nicotinic Acid—Emerging Roles in Replicative and Chronological Aging in Yeast

Orlandi

Alberghina²,

Vai

2020

Biomolecules

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Nicotinamide, nicotinic acid and nicotinamide riboside are vitamin B3 precursors of NAD + in the human diet. NAD + has a fundamental importance for cellular biology, that derives from its essential role as a cofactor of various metabolic redox reactions, as well as an obligate co-substrate for NAD + -consuming enzymes which are involved in many fundamental cellular processes including aging/longevity. During aging, a systemic decrease in NAD + levels takes place, exposing the organism to the risk of a progressive inefficiency of those processes in which NAD + is required and, consequently, contributing to the age-associated physiological/functional decline. In this context, dietary supplementation with NAD + precursors is considered a promising strategy to prevent NAD + decrease and attenuate in such a way several metabolic defects common to the aging process. The metabolism of NAD + precursors and its impact on cell longevity have benefited greatly from studies performed in the yeast Saccharomyces cerevisiae, which is one of the most established model systems used to study the aging processes of both proliferating (replicative aging) and non-proliferating cells (chronological aging). In this review we summarize important aspects of the role played by nicotinamide, nicotinic acid and nicotinamide riboside in NAD + metabolism and how each of these NAD + precursors contribute to the different aspects that influence both replicative and chronological aging. Taken as a whole, the findings provided by the studies carried out in S. cerevisiae are informative for the understanding of the complex dynamic flexibility of NAD + metabolism, which is essential for the maintenance of cellular fitness and for the development of dietary supplements based on NAD + precursors.

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NAD+ in Brain Aging and Neurodegenerative Disorders

Cited by 432 publications

References 231 publications

The current progress of histone deacetylase SIRT7

The current progress of histone deacetylase SIRT7

Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria

Nicotinamide, Nicotinamide Riboside and Nicotinic Acid—Emerging Roles in Replicative and Chronological Aging in Yeast

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