2021
DOI: 10.21037/tcr-20-2798
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NAD-dependent methylenetetrahydrofolate dehydrogenase inhibits oral squamous cell carcinoma cell proliferation and promotes apoptosis

Abstract: Background: NAD-dependent methylenetetrahydrofolate dehydrogenase catalyzes the conversion of 10-formyltetrahydrofolate to formate in embryonic and adult mammalian mitochondria.Methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) is a folate cycle enzyme that is involved in the development of various diseases including cancer. However, the specific mechanisms in oral squamous cell carcinoma (OSCC) are unclear. We analyzed the functional routes of MTHFD1L in OSCC cells.Methods: MTHFD1L expression in OSCC wa… Show more

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Cited by 9 publications
(5 citation statements)
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“…In this, we found five completely consistent proteins common across all the GPR19 expression doses in all three distinct cell compartment extracts: MDC1; MTHFD1L; PDCD5; ANP32C; MGEA5; SETBP1. Consistent with the overall molecular phenotype of GPR19, many of these proteins are linked to DNA damage [22,[50][51][52], energy metabolism [53][54][55][56][57][58][59], and oncology [60][61][62][63][64][65]. Generating a heatmap of these conserved DEPs, it was evident that a diverse array of expression polarities were found for these proteins across the distinct GPR19 expression doses/compartment extracts (Figure S3B).…”
Section: Distinctive Compartment-based Interpretation Of Gpr19 Pertur...mentioning
confidence: 52%
“…In this, we found five completely consistent proteins common across all the GPR19 expression doses in all three distinct cell compartment extracts: MDC1; MTHFD1L; PDCD5; ANP32C; MGEA5; SETBP1. Consistent with the overall molecular phenotype of GPR19, many of these proteins are linked to DNA damage [22,[50][51][52], energy metabolism [53][54][55][56][57][58][59], and oncology [60][61][62][63][64][65]. Generating a heatmap of these conserved DEPs, it was evident that a diverse array of expression polarities were found for these proteins across the distinct GPR19 expression doses/compartment extracts (Figure S3B).…”
Section: Distinctive Compartment-based Interpretation Of Gpr19 Pertur...mentioning
confidence: 52%
“…Inversely, MTHFD1L knockdown signi cantly decreased the tumor cell growth in papillary thyroid cancer (PTC) [23] . Similarly, decreased expression of MTHFD1L suppressed the tumor cell proliferation and promoted apoptosis in OSCC (oral squamous cell carcinoma) [24] . However, there are not systematic analysis about the functional roles of MTHFD1L in all kinds of cancer types.…”
Section: Discussionmentioning
confidence: 98%
“…These enzymes are activated downstream of several oncogenes, such as c-MYC and Tp53 [ 86 ]. These oncogenes have been associated with OC promotion and progression [ 87 , 88 ]. Therefore, elevated levels of metabolites involved in these pathways are expected, and their use as biomarker should be explored.…”
Section: Discussionmentioning
confidence: 99%