Nachweis von Proteaseninhibitoren im Intestinaltrakt von Mensch und Hund

Abstract

Aus Homogenaten von menschlichem Colon sowie Duodenum, Jejunum, Ueum und Colon vom Hund wurden säurestabile, niedermolekulare Proteaseninhibitoren angereichert. Sie hemmen Trypsin und Chymotrypsin. Der Hemmstoff aus menschlichem Material vermag zusätzlich Proteasen aus menschlichen Leukocyten zu hemmen. Detection of proteinaseinhibitors in the intestinal tract of man and dog Low molecular-weight acid stable proteinaseinhibitors are extracted from homogenzied human colon and dog duodenum, jejunum, ileum and colon. Trypsin and chymotrypsin are inhibited by this products. The inhibitor from human material also inhibits proteases from human leucocytes.

The Distribution of Enzymes and Bacteria in the Small Intestines of Slaughter Pigs

“…Thus-in contrast to the feed-containing parts, the inhibitors may be present in excess and lead to an inactivation of proteinases possibly still present. The presence of proteinase inhibitors in the intestinal content of man and dog has previously been demonstrated by Hochstrasser et al ( 1972), however, without reference to the distribution of enzymatic activity and the character of the content.…”