Nachweis und Lokalisation von Porphyrinen im Nierenbiopsiegewebe bei chronischer hepatischer Porphyrie (Porphyria cutanea tarda) mittels Fluorescenzmikroskopie

Czitober, H; Denk, Helmut; Schnack, Hugo G.

doi:10.1007/bf01486136

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…The work of Ivanov et at. [10] on experimental porphyria in rats supports ear lier observations [3,19] that the proximal tubules and loop of Henle play a major role in urinary porphyrin excretion. Clinical interest in the porphyrin status in chronic renal failure has been aroused by the dermatologic abnormali ties, especially cutaneous blistering eruptions, reported recently [8,12.17].…”

Section: Introductionsupporting

confidence: 65%

Porphyrins in Chronic Renal Failure

Day¹,

Eales²

1980

Nephron

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A highly sensitive thin layer chromatographic assay was used to establish distinct anomalies in hepatic and renal prophyrin synthesis associated with chronic renal failure. Urinary and plasma coproporphyrin disappeared but plasma uroporphyrin (isomer III) levels rose. Patients on maintenance hemodialysis showed elevated red cell protoporphyrin and decreased total stool porphyrins whilst the raised plasma uroporphyrin did not pass into the dialysate, even in 2 cases of overt symptomatic porphyria. These results indicate that urinary coproporphyrin is of renal and not hepatic origin and that azotemia may reduce the activity of the enzyme uroporphyrinogen decarboxylase.

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Section: Introductionsupporting

confidence: 65%

Porphyrins in Chronic Renal Failure

Day¹,

Eales²

1980

Nephron

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“…From the point of view of the filtration-resorption-secretion theory of urine formation, the fluorescence microscopy demonstration of porphyrins in the proximal tubules and the loop of Henle cannot elucidate the exact mechanism of their excretion [5], The proximal tubule is the site where secretion and active and passive reabsorption of some organic substances take place. Glomerular involvement in this process cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

“…The finding of porphyrin deposited in the epithelial cells of the proximal tubules and the loop of Henle in occasional victims of lead poisoning [16]. porphyria variegata [10] and acute porphyria [17], as well as in puncture biopsy specimens obtained from patients with porphyria cutanea tarda symp tomatica [5] is strongly suggestive that it is particularly these segments of the nephrone that play a role in porphyrin excretion. Bhrman et al[2] maintain the contrary assumption that porphyrins are excreted only by way of glom erular filtration.…”

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confidence: 99%

Porphyrin Metabolism in Renal Diseases

Ivanov¹,

Todorov²,

Adjarov³

et al. 1976

Nephron

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Fluorescence microscopy in experimental hexachlorobenzene porphyria in rats has demonstrated porphyrin deposits in the epithelial cells of the proximal renal tubules and the loop of Henle. In the glomeruli, interstitium, distal tubules, and the collecting tubules, no porphyrins were detected. The similarity of this finding with the data on some forms of porphyrinuria and porphyria in man suggests that the proximal tubules and the loop of Henle play an important role in the mechanism of renal porphyrin excretion.

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“…There have been several observations of excess por phyrins in renal tissues, and in the more detailed, involving both humans [5] and animals [6,7] with disturbed heme metabolism, the greatest concentrations were found in the proximal convoluted tubules. Few researchers, however, have investigated renal porphyrin synthesis per se, since it is generally assumed that any excesses in the kidney result from the passive deposition of elevated porphyrins from the filtrate.…”

mentioning

confidence: 99%