Nachversicherung

Jungbauer, Andreas

doi:10.1007/978-3-663-13175-5

Cited by 1 publication

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“…We emphasize here that the results indicate that the concentration of stress fibers is not very sensitive to the loading rate. However, consistent with observations [30], the stress exerted by the fibers depends strongly on the rate of deformation, as characterized by Eq. (B2).…”

Section: Effect Of Loading Ratesupporting

confidence: 76%

An Analysis of the Cooperative Mechano-Sensitive Feedback Between Intracellular Signaling, Focal Adhesion Development, and Stress Fiber Contractility

Pathak

McMeeking

Evans

et al. 2011

Journal of Applied Mechanics

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Cells communicate with their external environment via focal adhesion.i and generate activation signals that in turn trigger the activity of the intraceiiuiar contractile machinery. These signals can be triggered by mechanical loading that gives rise to a cooperative feedback loop among signaling, focal adhesion formation, and cytoskeletal contractility, which in turn equilibrates with the applied mechanical loads. We devise a signaling model that couples stress ftber contractility and mechano-sensitive focal adhesion models to complete this above mentioned feedback loop. The signaling model is based on a biochemical pathway where IP} molecules are generated when focal adhesions grow. These IP¡ molecules diffuse through the cytosol leading to the opening of ion channels that disgorge Ca^''' from the endoplasmic reticulum leading to the activation of the actin/myosin contractile machinery. A simple numerical example is presented where a one-dimensional cell adhered to a rigid substrate is pulled at one end, and the evolution of the stress fiber activation signal, stress fiber concentrations, and focal adhesion distributions are investigated. We demonstrate that while it is sufficient to approximate the activation signal as spatially uniform due to the rapid diffusion of the IPf through the cytosol, the level of the activation signal is sensitive to the rate of application of the mechanical loads. This suggests that ad hoc signaling models may not be able to capture the mechanical response of cells to a wide range of mechanical loading events.

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Section: Effect Of Loading Ratesupporting

confidence: 76%