NACHO permits functional heterologous expression of an insect homomeric α6 nicotinic acetylcholine receptor

Hawkins, Joseph A.; Mitchell, Eleanor L.; Jones, Andrew K.

doi:10.1016/j.pestbp.2021.105030

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Case Study: Spinosad Discovery At Eli Lilly1

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2022

2023

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Cited by 2 publications

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“…Together, they all strongly suggested that spinosad had a new MOA, although, at that time, the team did not know what it was. The MOA of spinosad was later identified as a nicotinic acetylcholine receptor inhibitor and targeted specifically at the α6 subunit on the receptor. − …”

Section: Case Study: Spinosad Discovery At Eli Lillymentioning

confidence: 99%

Pesticide Research and Development: General Discussion and Spinosad Case

Chio

2022

J. Agric. Food Chem.

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On average, it has taken approximately 10 years and $250 million to discover and develop one pesticide out of approximately 100 000 compounds. A successful pesticide researcher nowadays needs to be knowledgeable and skillful in multiple disciplines. As a result of the high costs and unique requirements, only a handful of companies in the world can afford to continue pesticide research and development (R/D) in the $70 billion pesticide market. Pesticide R/D is a high-risk yet high-reward business. In this perspective, pesticide R/D is briefly discussed and a case study is used to illustrate how spinosad was discovered and became a successful product, despite the many challenges facing pesticide R/D.

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