NABC1 (BCAS1): Alternative Splicing and Downregulation in Colorectal Tumors

Correa, Ricardo G.; Carvalho, Alex F.; Pinheiro, Nídia Alice; Simpson, Andrew; Souza, Sandro J. de

doi:10.1006/geno.2000.6172

Cited by 21 publications

(9 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Proteins related to other cancers are also found in this dataset, such as BCAS1, which has been described as a strong candidate oncogene for breast cancer (Collins et al, 1998). Surprisingly, compared to breast cancer, in which upregulation is observed for this protein, an opposite trend is found in colorectal cancer (Correa et al, 2000). The same trend is found in our study; once again, proteomics data of organoids is recapitulating observations made with biopsy specimens.…”

Section: Establishing a Human Crc Organoid Expression Profile By Quansupporting

confidence: 88%

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

et al. 2017

View full text Add to dashboard Cite

Diseases at the molecular level are complex and patient dependent, necessitating development of strategies that enable precision treatment to optimize clinical outcomes. Organoid technology has recently been shown to have the potential to recapitulate the in vivo characteristics of the original individual's tissue in a three-dimensional in vitro culture system. Here, we present a quantitative mass-spectrometry-based proteomic analysis and a comparative transcriptomic analysis of human colorectal tumor and healthy organoids derived, in parallel, from seven patients. Although gene and protein signatures can be derived to distinguish the tumor organoid population from healthy organoids, our data clearly reveal that each patient possesses a distinct organoid signature at the proteomic level. We demonstrate that a personalized patient-specific organoid proteome profile can be related to the diagnosis of a patient and with future development contribute to the generation of personalized therapies.

show abstract

Section: Establishing a Human Crc Organoid Expression Profile By Quansupporting

confidence: 88%

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…If GATA3 does help to control expression of NHERF1 this might be one mechanism consistent with its role in the less-aggressive differentiated luminal A breast cancers. Another example is BCAS1 (NABC1) which is overexpressed in breast carcinomas but downregulated in colorectal tumours [ 22 , 23 ]. Indeed, overexpression of NABC1 did not result in changes in cell-cycle or anchorage-dependent growth properties in NIH3T3 cells, implying it may not be intrinsically oncogenic [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

Wilson

Giguère

2008

Molecular Cancer

View full text Add to dashboard Cite

Background: The transcription factor GATA3 has recently been shown to be necessary for mammary gland morphogenesis and luminal cell differentiation. There is also an increasing body of data linking GATA3 to the estrogen receptor α (ERα) pathway. Among these it was shown that GATA3 associates with the promoter of the ERα gene and ERα can reciprocally associate with the GATA3 gene. GATA3 has also been directly implicated in a differentiated phenotype in mouse models of mammary tumourigenesis. The purpose of our study was to compare coexpressed genes, by meta-analysis, of GATA3 and relate these to a similar analysis for ERα to determine the depth of overlap.

show abstract

“…The BCAS1 (Breast carcinoma amplified sequence 1, also named NABC1) gene, which was located at 20q13, was amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. [23][24][25] Correa et al 24 found that BCAS1 was overexpressed in breast tumors and both NABC1 and NABC1_5B were down-regulated in colorectal tumors. In current study, rs3787547-Aallele was identified to increase the susceptibility of OS.…”

Section: Discussionmentioning

confidence: 99%

Association between genetic variants in p53 binding sites and risks of osteosarcoma in a Chinese population: a two-stage case-control study

Zhang

et al. 2018

Cancer Biology & Therapy

View full text Add to dashboard Cite

Osteosarcoma (OS) is one of the most common bone malignancies in children and adolescents. To date, inaugural mechanism of OS was considered as a complex process and was still not clear. The p53 gene, most important tumor suppressors, was associated with risk of many tumors, including OS. In current study, we evaluated the relationship between genetic variation of the p53 binding site and the OS susceptibility through a two-stage case-control study in Chinese population. We found that rs1295925 (OR = 0.85; 95 CI = 0.76-0.94; P = 0.003) and rs3787547 (OR = 1.27; 95 CI = 1.11-1.45; P = 4.0 × 10) was significantly with OS susceptibility. Compared with those with rs1295925-TT genotype, and the risk of OS was significantly lower in individuals with CT genotype (OR = 0.77; 95 CI = 0.65-0.92) and CC genotype (OR = 0.75; 95 CI = 0.60-0.93). Compared with those with rs3787547-GG genotype, and the risk of OS was significantly higher in individuals with AG genotype (OR = 1.32; 95 CI = 1.10-1.58) and AA genotype (OR = 1.46; 95 CI = 1.11-1.92). To sum up, our results prove that SNP rs1295925 and rs3787547 play an important role in the etiology of OS, suggesting them as the potential genetic modifier for OS development.

show abstract

NABC1 (BCAS1): Alternative Splicing and Downregulation in Colorectal Tumors

Cited by 21 publications

References 4 publications

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

Association between genetic variants in p53 binding sites and risks of osteosarcoma in a Chinese population: a two-stage case-control study

Contact Info

Product

Resources

About