Na+-Phosphate Cotransport in Mouse Distal Convoluted Tubule Cells: Evidence for Glvr-1 and Ram-1 Gene Expression

Tenenhouse, Harriet S.; Gauthier, Claude; Martel, Josée; Gesek, F. A.; Coutermarsh, Bonita; Friedman, Peter A.

doi:10.1359/jbmr.1998.13.4.590

Cited by 37 publications

(35 citation statements)

References 46 publications

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“…Finally type I and II and Pit1 and Pit2 are differentially regulated. Increases in alkaline pH stimulate increased P i uptake by the kidney-specific P i transporters, whereas type III P i uptake is decreased under these conditions (174). Pit2-but not Pit1-mediated P i uptake is specifically regulated by protein kinase C epsilon (77), and Pit1 is specifically regulated by insulin-like growth factor I in osteoblast-like cells (131).…”

Section: Amphotropic Mlvs Galv Woolly Monkey Virus and Felv-b All mentioning

confidence: 97%

Receptors and Entry Cofactors for Retroviruses Include Single and Multiple Transmembrane-Spanning Proteins as well as Newly Described Glycophosphatidylinositol-Anchored and Secreted Proteins

Overbaugh

Miller

Eiden³

2001

Microbiol Mol Biol Rev

172

165

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SUMMARY In the past few years, many retrovirus receptors, coreceptors, and cofactors have been identified. These molecules are important for some aspects of viral entry, although in some cases it remains to be determined whether they are required for binding or postbinding stages in entry, such as fusion. There are certain common features to the molecules that many retroviruses use to gain entry into the cell. For example, the receptors for most mammalian oncoretroviruses are multiple membrane-spanning transport proteins. However, avian retroviruses use single-pass membrane proteins, and a sheep retrovirus uses a glycosylphosphatidylinositol-anchored molecule as its receptor. For some retroviruses, particularly the lentiviruses, two cell surface molecules are required for efficient entry. More recently, a soluble protein that is required for viral entry has been identified for a feline oncoretrovirus. In this review, we will focus on the various strategies used by mammalian retroviruses to gain entry into the cell. The choice of receptors will also be discussed in light of pressures that drive viral evolution and persistence.

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Section: Amphotropic Mlvs Galv Woolly Monkey Virus and Felv-b All mentioning

confidence: 97%

Receptors and Entry Cofactors for Retroviruses Include Single and Multiple Transmembrane-Spanning Proteins as well as Newly Described Glycophosphatidylinositol-Anchored and Secreted Proteins

Overbaugh

Miller

Eiden³

2001

Microbiol Mol Biol Rev

172

165

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“…Deletion of PiT1 expression in mouse results in fetal demise due to failure of liver development (92,93). Although adult liver expresses little PiT1, fetal liver expresses very high levels of PiT1.…”

Section: Pit1mentioning

confidence: 99%

Clinical Consequences of Mutations in Sodium Phosphate Cotransporters

Lederer

Miyamoto

2012

Clinical Journal of the American Society of Nephrology

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SummaryThree families of sodium phosphate cotransporters have been described. Their specific roles in human health and disease have not been defined. Review of the literature reveals that the type II sodium phosphate cotransporters play a significant role in transepithelial transport in a number of tissues including kidney, intestine, salivary gland, mammary gland, and lung. The type I transporters seem to play a major role in renal urate handling and mutations in these proteins have been implicated in susceptibility to gout. The ubiquitously expressed type III transporters play a lesser role in phosphate homeostasis but contribute to cellular phosphate uptake, mineralization, and inflammation. The recognition of species differences in the expression, regulation, and function of these transport proteins suggests an urgent need to find ways to study them in humans.

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“…PiT proteins may also play a role in P i transport in the distal segments of the kidney. Tenenhouse et al (99) showed that both PiT-1 and PiT-2 mRNAs are present in immortalized mouse distal convoluted tubule (MDCT) cells and that the pH dependence of P i transport is consistent with PiT-mediated transport.…”

Section: /P I Cotransporter Familymentioning

confidence: 99%

Phosphate transporters: a tale of two solute carrier families

Virkki¹,

Biber²,

Murer³

et al. 2007

American Journal of Physiology-Renal Physiology

215

227

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Phosphate is an essential component of life and must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pitransporters carry out this task. Remarkably, the two families transport different Pispecies: whereas type II Na+/Picotransporters (SCL34) prefer divalent HPO42−, type III Na+/Picotransporters (SLC20) transport monovalent H2PO4−. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes of the gut and kidney, they maintain body Pihomeostasis, and in salivary and mammary glands, liver, and testes they play a role in modulating the Picontent of luminal fluids. The two SLC20 family members PiT-1 and PiT-2 are electrogenic and ubiquitously expressed and may serve a housekeeping role for cell Pihomeostasis; however, also more specific roles are emerging for these transporters in, for example, bone mineralization. In this review, we focus on recent advances in the characterization of the transport kinetics, structure-function relationships, and physiological implications of having two distinct Na+/Picotransporter families.

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Na+-Phosphate Cotransport in Mouse Distal Convoluted Tubule Cells: Evidence for Glvr-1 and Ram-1 Gene Expression

Abstract: While there is considerable evidence for phosphate (Pi) reabsorption in the distal tubule, Pi transport and its regulation have not been well characterized in this segment of the nephron. In the present study, we examined Na

Cited by 37 publications

References 46 publications

Receptors and Entry Cofactors for Retroviruses Include Single and Multiple Transmembrane-Spanning Proteins as well as Newly Described Glycophosphatidylinositol-Anchored and Secreted Proteins

Receptors and Entry Cofactors for Retroviruses Include Single and Multiple Transmembrane-Spanning Proteins as well as Newly Described Glycophosphatidylinositol-Anchored and Secreted Proteins

Clinical Consequences of Mutations in Sodium Phosphate Cotransporters

Phosphate transporters: a tale of two solute carrier families

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