“…Due to this effect, cardiotonic steroids digoxin and digitoxin have been essential therapeutics for the treatment of heart failure and arrhythmia. ,− However, the biological activity of cardenolides extends well beyond their cardiotonic activity. Among numerous other applications, cardiotonic steroids have been explored as potential therapeutic agents for the treatment of cancer, − viral infections, , neurodegenerative diseases, , and stroke − and as anti-inflammatory ,, and senolytic agents. Particularly interesting are the recent reports indicating that cardiotonic steroids, such as ouabain and digoxin, may influence the peripheral and central nervous systems.…”