Na,K-ATPase activity promotes macropinocytosis in colon cancer via Wnt signaling
Nydia Tejeda-Muñoz,
Yagmur Azbazdar,
Eric A. Sosa
et al.
Abstract:Recent research has shown that membrane trafficking plays an important role in canonical Wnt signaling through sequestration of the β-catenin destruction complex inside multivesicular bodies (MVBs) and lysosomes. In this study, we introduce Ouabain, an inhibitor of the Na,K-ATPase pump that establishes electric potentials across membranes, as a potent inhibitor of Wnt signaling. We find that Na,K-ATPase levels are elevated in advanced colon carcinoma, that this enzyme is elevated in cancer cells with constitut… Show more
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