Abstract:The long-term (34 weeks) effect of streptozotocin induced diabetes was assessed in Wistar rats.Na + /K + -ATPase activity was measured by ouabain inhibitable 86 Rb + -uptake into erythrocytes. No difference in the rate of Rb + -uptake, the K m for Rb + or the K i for ouabain was detected between normal and diabetic rats. Thus, the change in Na + /K + -ATPase activity repeatedly described in short-term studies may not translate into a long term physiologically relevant change in ion flux through the sodium pump… Show more
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