Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger
Guilherme Henrique Souza Bomfim,
Erna Mitaishvili,
Paul P.M. Schnetkamp
et al.
Abstract:Calcium (Ca2+) extrusion is an essential function of the enamel-forming ameloblasts, providing Ca2+ for extracellular mineralization. The plasma membrane Ca2+ ATPases (PMCAs) remove cytosolic Ca2+ (cCa2+) and were recently shown to be efficient when ameloblasts experienced low cCa2+ elevation. Sodium–calcium (Na+/Ca2+) exchange has higher capacity to extrude cCa2+, but there is limited evidence on the function of the two main families of Na+/Ca2+ exchangers in enamel formation. The purpose of this study was to… Show more
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