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Lephart, Edwin D.; Porter, James P.; Lund, Trent D.; Bu, Le; Setchell, Kenneth D.R.; Ramoz, Gina; Crowley, William R.

doi:10.1186/1743-7075-1-16

Cited by 63 publications

(28 citation statements)

References 50 publications

(57 reference statements)

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“…Each diet protocol is outlined below by experiment number and descriptor. Furthermore, the diet formulations (ingredient list) have been published previously [17-19]. Notably, for the soy-rich (Phyto-600) diet, soy meal is the first ingredient and this diet treatment does not contain a soy protein isolate.…”

Section: Methodsmentioning

confidence: 99%

“…Serum was analyzed via gas chromatography/mass spectrometry (GC/MS) and the circulating isoflavones: genistein, daidzein, and equol concentrations were determined (ng/ml) using internal control standards, as previously reported in other studies by our laboratory [18,19]. …”

Section: Methodsmentioning

confidence: 99%

“…Notably, in a comprehensive study the beneficial influences of soy-derived isoflavones via diet were examined that included body weight, adipose tissue deposition, food and water intake, metabolic hormones (i.e. leptin, insulin, thyroid (T3) and glucose levels), brain neuropeptide Y (NPY) levels in hypothalamic regions, heat production [in brown adipose tissue (BAT) quantifying uncoupling protein (UCP-1) mRNA levels] and core body temperature [19]. …”

Section: Introductionmentioning

confidence: 99%

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Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects

et al. 2011

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BackgroundSoy-derived isoflavones potentially protect against obesity and depression. In five different studies we examined the influence of soy-containing diets or equol injections on depression, serotonin levels, body weight gain (BW) and white adipose tissue (WAT) deposition in female Long-Evans rats at various stages of life [rats were intact, ovariectomized or experienced natural ovarian failure (NOF)].ResultsIn general, animals fed a soy-rich diet (Phyto-600) and/or administered equol (@ 5 mg/kg/day) displayed significant decreases in BW and WAT compared to a low-soy diet. When equol was injected alone (5 mg/kg/day), experiments 1, 4, and 5 demonstrated that body weight was significantly decreased. Equol has body weight control effects in females that are dependent on ovarian status and/or age of diet initiation. Experiments 1-4 all displayed no significant differences in depressive-related behavior as measured by the Prosolt forced swim test (PFST) when soy-rich (Phyto-600) or low-soy diets (Phyto-low) or equol treatments (5 mg/kg/day) were tested in female rats at various ages or hormonal status. Results of all the experiments are not presented here due to space limitations, but data from experiment 5 are presented. From conception female rats were exposed to either: a) a soy-rich (Phyto-600) or b) low-soy diet (Phyto-low). After 290 days all rats experienced NOF. At 330 days-old the animals were examined in the Porsolt forced swim test (PFST). One month later a second PFST was performed [after Phyto-low fed animals were injected with equol (5 mg/kg/day) for one week prior to the second PFST]. At the first PFST, serotonin and mobility levels were significantly decreased in the Phyto-low fed animals compared to animals that consumed the Phyto-600 diet. After equol injections at the second PFST, mobility and serotonin levels significantly increased in aged NOF rats fed the Phyto-low diet (to levels comparable to Phyto-600 fed animals).ConclusionsConsumption of dietary isoflavones or equol exposure in rats has body weight controlling effects and equol specifically may have antidepressant potential dependent upon diet initiation and/or dosage of treatments. The current study demonstrates that equol is able to decrease body weight, abdominal WAT, and depressive-related behavior. While other factors and mechanisms may play a role, in part, the present results provide a greater understanding of how isoflavonoid molecules modulate the brain's influence on behavior.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects

et al. 2011

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“…Male Long-Evans rats exposed (from conception to time of testing or tissue collection) to a diet rich in isoflavones showed increased total T 3 levels [108]. Studies have shown that exposure of infants to soy-based formulas complicates management of congenital hypothyroidism [109][110][111][112].…”

Section: Tsh Stimulation and Iodination Inhibitionmentioning

confidence: 99%

The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development

Mastorakos

Karoutsou

Mizamtsidi

et al. 2007

Endocr

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The delivery of the appropriate thyroid hormones quantity to target tissues in euthyroidism is the result of unopposed synthesis, transport, metabolism, and excretion of these hormones. Thyroid hormones homeostasis depends on the maintenance of the circulating 'free' thyroid hormone reserves and on the development of a dynamic balance between the 'free' hormones reserves and those of the 'bound' hormones with the transport proteins. Disturbance of this hormone system, which is in constant interaction with other hormone systems, leads to an adaptational counter-response targeting to re-establish a new homeostatic equilibrium. An excessive disturbance is likely to result, however, in hypo- or hyper- thyroid clinical states. Endocrine disruptors are chemical substances forming part of 'natural' contaminating agents found in most ecosystems. There is abundant evidence that several key components of the thyroid hormones homeostasis are susceptible to the action of endocrine disruptors. These chemicals include some chlorinated organic compounds, polycyclic aromatic hydrocarbons, herbicides, and pharmaceutical agents. Intrauterine exposure to endocrine disruptors that either mimic or antagonize thyroid hormones can produce permanent developmental disorders in the structure and functioning of the brain, leading to behavioral changes. Steroid receptors are important determinants of the consequences of endocrine disruptors. Their interaction with thyroid hormones complicates the effect of endocrine disruptors. The aim of this review is to present the effect of endocrine disruptors on thyroid hormones physiology and their potential impact on intrauterine development.

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“…The general formula of soy isoflavones and related glucosides. Cheng et al 2004;Lephart et al 2004). Also, it should be mentioned that genistein, in some animal models, reduces lipoprotein lipase gene expression in adipose tissue, which contributes to diminished lipid uptake by fat cells and to the prominent anti-obesity effects (Naaz et al 2003).…”

Section: General Considerationsmentioning

confidence: 99%

Glucocorticoid excess and disturbed hemodynamics in advanced age: the extent to which soy isoflavones may be beneficial

Ajdžanović¹,

Milošević²,

Spasojević³

2012

gpb

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Abstract. Advanced age is often accompanied by glucocorticoid excess which contributes to the pathogenesis of the metabolic syndrome associated with some hemodynamic disorders. Impaired central regulation of stress hormones secretion and increased glucocorticoids/adrenal androgens ratio trigger hyperglycemia, elevated blood lipids and visceral fat accumulation, associated with hypertension and increased blood viscosity, all of which represent cardiovascular morbidity factors in this age. Finding the adequate therapeutic solutions is set as an imperative in the treatment of listed symptoms. Biologically active soy isoflavones, exhibiting estrogen-and membrane-receptor agonistic/antagonistic activity, and antioxidative and tyrosine kinase/steroidogenic enzyme inhibiting effects, appear as alternative therapeutics for various ageing-related diseases. It has been shown that soy isoflavones reduce some of the listed risk factors, while affecting the hemodynamic group of cardiovascular parameters directly, as well as indirectly via endocrine perturbations. Soy isoflavones may reverse the glucocorticoids/adrenal androgens ratio, lower serum cholesterol, slow the development of atherosclerotic plaque formation, inhibit platelet aggregation, increase cardiac contractility, but they may have diverse effects on blood viscosity and may increase triglyceride levels. Herein, we present the projection of soy isoflavones-based therapy of glucocorticoid excess and disturbed hemodynamics in advanced age, concluding that although promising, it requires the impartial approach and certain precautions.

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Untitled

Cited by 63 publications

References 50 publications

Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects

Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects

The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development

Glucocorticoid excess and disturbed hemodynamics in advanced age: the extent to which soy isoflavones may be beneficial

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Untitled

Cited by 63 publications

References 50 publications

Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects

Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects

The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development

Glucocorticoid excess and disturbed hemodynamics in advanced age: the extent to which soy isoflavones may be beneficial

Contact Info

Product

Resources

About

Glucocorticoid excess and disturbed hemodynamics in advanced age: the extent to which soy isoflavones may be beneficial