Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation

Massiéra, Florence; Bloch-Faure, May; Ceiler, Debbie L.; Murakami, Kazuo; Fukamizu, Akiyoshi; Gasc, Jean‐Marie; Quignard‐Boulangé, Annie; Négrel, Raymond; Ailhaud, Gérard; Seydoux, Josiane; Meneton, Pierre; Teboul, Michèle

doi:10.1096/fj.01-0457fje

Cited by 447 publications

(420 citation statements)

References 36 publications

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“…[23][24][25] Hall et al 19 reported a more than twofold increase in plasma renin activity after a 5-week period of highfat diet administration in conscious dogs. Moreover, fat restriction succeeded in diminishing the values of the RAS components, indicating the possibility that the degree of adiposity might have a direct influence in this BP-regulating system.…”

Section: Function Of Ras In Obesity Hypertensionmentioning

confidence: 99%

Mechanisms of obesity-induced hypertension

et al. 2010

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The relationship between obesity and hypertension is well established both in children and adults. The mechanisms through which obesity directly causes hypertension are still an area of research. Activation of the sympathetic nervous system has been considered to have an important function in the pathogenesis of obesity-related hypertension. The arterial-pressure control mechanism of diuresis and natriuresis, according to the principle of infinite feedback gain, seems to be shifted toward higher blood-pressure levels in obese individuals. During the early phases of obesity, primary sodium retention exists as a result of increase in renal tubular reabsorption. Extracellular-fluid volume is expanded and the kidney-fluid apparatus is resetted to a hypertensive level, consistent with a model of hypertension because of volume overload. Plasma renin activity, angiotensinogen, angiotensin II and aldosterone values display significant increase during obesity. Insulin resistance and inflammation may promote an altered profile of vascular function and consequently hypertension. Leptin and other neuropeptides are possible links between obesity and the development of hypertension. Obesity should be considered as a chronic medical condition, which is likely to require long-term treatment. Understanding of the mechanisms associated with obesity-related hypertension is essential for successful treatment strategies. Hypertension Research (2010) 33, 386-393; doi:10.1038/hr.2010.9Keywords: leptin; obesity; pressure natriuresis; rennin-angiotensin-aldosterone system; sympathetic nervous system INTRODUCTION Obesity is a common disorder that develops from the interaction between the genotype and the environment and involves social, behavioral, cultural, physiological, metabolic and genetic factors. A large number of studies have shown that obesity has an important negative impact on health in a population, leading to the recommendation for general practitioners to have an important function in the management of this condition and of its associated comorbidities such as hypertension, hyperlipidemia and hyperinsulinemia/insulin resistance. The relationship between obesity and hypertension is well established both in adults and children. 1,2 Obese individuals exhibit higher levels of office as well as ambulatory blood pressure (BP) from childhood to old age. Obese subjects display higher BP levels than non-obese individuals even in the normotensive range. The combination of obesity, hypertension and other cardiovascular risk factors significantly increases the probability of adverse cardiovascular outcomes, and raises considerations for aggressive treatment strategies. 3 The mechanisms through which obesity directly causes hypertension are still an area of research. Human and animal studies have elucidated the function of adipose tissue derivatives (adipokines and cytokines), neurohumoral pathways, metabolic functions and modulation of pressor/depressor mechanisms. Although obesity-related hypertension may be the result of a combinatio...

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Section: Function Of Ras In Obesity Hypertensionmentioning

confidence: 99%

Mechanisms of obesity-induced hypertension

et al. 2010

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“…Mice with targeted deletion of AGT have decreased blood pressure and adipose tissue mass (68), whereas mice with transgenic overexpression of AGT in adipose tissue have increased blood pressure and adipose tissue mass (69). In addition, mice with transgenic amplification of glucocorticoids due to overexpression 11␤-hydroxysteroid dehydrogenase type 1 (11␤HSD1) in adipose tissue develop hypertension associated with activation of the RAS including increased plasma AGT, angiotensin II, and aldosterone (70).…”

Section: Proteins Of the Renin Angiotensin System (Ras)mentioning

confidence: 99%

Adipose Tissue as an Endocrine Organ

Ahima

Flier

2000

Trends in Endocrinology & Metabolism

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“…AGT is extensively produced in adipose tissue, which is responsible for 30 % of its plasma concentration in laboratory rodents (Massiéra et al 2001). In rodent models, angiotensin II contributes to adipose tissue proliferation by binding on both AT1 and AT2 receptors (Kouyama et al 2005;Yvan-Charvet et al 2009), which is opposed by angiotensin 1-7 acting on Mas receptors (Santos et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

et al. 2015

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Angiotensinogen (AGT), its active fragments and microRNA-31 (miR-31) play an important role in adipocyte differentiation. AGT contains a miR-31 polymorphic binding site. We hypothesize that the rs7079 polymorphism in the miR-31/584 binding site of the AGT gene could influence body fat distribution. A total of 751 subjects (195 men, 556 women) were enrolled in the study. The rs7079 genotypes were determined by qRT-PCR. Anthropometric measurements were taken on all subjects, who were subsequently divided into two groups: obese ([30 kg m -2 ) and non-obese (\30 kg m -2 ). Linear regression models were created to determine the contributions of sex, obesity status and rs7079 to all measured parameters. Adding the rs7079 genotype significantly contributed to the linear regression model for waist circumference (p = 0.013), hip circumference (p = 0.018) and supraspinal skin-fold thickness (p = 1 9 10 -3 ). Differences between sexes and between the obese and nonobese groups were observed. Waist circumference was lower in men carrying the A allele (p = 0.022); hip circumference was higher only in obese women carrying the A allele (p = 0.015). While men carrying the A allele had lower supraspinal skin-fold thickness (p = 0.022), this parameter was found to be higher in A allele carrying women (p = 3 9 10 -3 ). The higher total sum of skin-fold thickness in A allele carrying women was restricted to obese individuals (p = 0.028). The presence of the A allele was associated with both lower tricipital skin-fold thickness in non-obese women (p = 0.023) and a trend of higher thickness in non-obese men (p = 0.065). Significant associations of rs7079 in the AGT gene and body fat distribution were observed. The distribution followed opposing patterns in both sexes.

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Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation

Cited by 447 publications

References 36 publications

Mechanisms of obesity-induced hypertension

Mechanisms of obesity-induced hypertension

Adipose Tissue as an Endocrine Organ

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

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