N7-Methylguanosine Genes Related Prognostic Biomarker in Hepatocellular Carcinoma

Regmi, Parbatraj; He, Zhiqiang; Lia, Thongher; Paudyal, Aliza; Li, Fuyu

doi:10.3389/fgene.2022.918983

Cited by 8 publications

(6 citation statements)

References 52 publications

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“…Mei et al obtained m7G-related genes from former literatures and GSEA website and established a three-gene signature (EIF3D, EIF4A1, LARP1) via univariate and LASSO Cox regression in prostate cancer [22]. Regmi et al acquired m7G-related genes from prior studies and established a three m7G-related signature model (CDK1, ANO1, and PDGFRA) through univariate and LASSO Cox regression in hepatocellular carcinoma [23]. Fei Lu et al retrieved 29 m7G-related genes from published literature and Molecular Signatures Database and identi ed 15 genes associated with overall survival of lung adenocarcinoma [24].…”

Section: Discussionmentioning

confidence: 99%

A novel m7G-related signature to predict prognosis and immune status in patients with hepatocellular carcinoma

Wang

Chen

Liu

2023

Preprint

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Background 7-methylguanosine (m7G) is one of the most common RNA methylation modification, which is closely related to the development of many types of tumors. However, the role of m7G-related genes in hepatocellular carcinoma (HCC) remains unclear. We wanted to investigate the influence of m7G-related genes on the prognosis of HCC and establish a novel model to assess the potential prognostic application in HCC. Methods Firstly, we screened differentially expressed m7G-related genes in HCC using The Cancer Genome Atlas (TCGA) database. Then, a novel risk model according to the m7G-related genes for prognosis was built via univariate and multivariate regression. Furthermore, its reliability was verified by Kaplan-Meier method, ROC analysis, PCA, and t-SNE analyses. Functional enrichment, immune status, tumor mutation burden, immune checkpoints, patients response to chemotherapeutics were analyzed among the different risk groups. Eventually, the novel m7G-related prognostic signature was validated in external ICGC and human protein atlas database. Results 27 differentially expressed m7G-related genes were screened, and EIF4E, GEMIN5, WDR4, NCBP2, NUDT5 were used to build a novel prognostic model. Individuals in the high risk category possessed remarkable poorer overall survival than their counterparts. We demonstrated that m7G-related risk model could be utilized as an independent prognostic marker for HCC patients and showed a good concordance with the prediction. We discovered that clinicopathological characteristics, immune cell infiltrations, immune function and tumor microenvironment differed dramatically between two risk groups. Additionally, high risk patients may possess a better response to immunotherapy and chemotherapeutic drug therapy. Finally, ICGC and immunohistochemical images confirmed our results. Conclusions This study furnished a novel forecast signature for predicting the prognosis of HCC patients and built a considerable foundation for future researches of the relationships between m7G-related genes and immunity in HCC.

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Section: Discussionmentioning

confidence: 99%

A novel m7G-related signature to predict prognosis and immune status in patients with hepatocellular carcinoma

Wang

Chen

Liu

2023

Preprint

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“… 112 CDK1‐based ANO1 prognostic modelling can accurately predict the prognosis of HCC patients. 113 ANO1 is closely associated with vascular infiltration and negatively correlated with HCC prognosis. 114 Diltiazem is a calcium channel blocker that suppresses tumour growth by inhibiting calcium influx.…”

Section: Pathologic Role Of Ano1 In the Livermentioning

confidence: 98%

“…Cell cycle protein‐dependent kinase 1 (CDK1) is highly expressed in HCC tissues and is associated with poor prognosis 112 . CDK1‐based ANO1 prognostic modelling can accurately predict the prognosis of HCC patients 113 . ANO1 is closely associated with vascular infiltration and negatively correlated with HCC prognosis 114 .…”

Section: Pathologic Role Of Ano1 In the Livermentioning

confidence: 99%

The role of anoctamin 1 in liver disease

Li,

Wang,

Zhang

et al. 2024

J Cellular Molecular Medi

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Liver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium‐activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional regulation as well as in many signalling pathways. It is involved in the genesis, development, progression and/or metastasis of several tumours and other diseases including liver diseases. This paper reviews the role and molecular mechanisms of ANO1 in the development of various liver diseases, aiming to provide a reference for further research on the role of ANO1 in liver diseases and to contribute to the improvement of therapeutic strategies for liver diseases by regulating ANO1.

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“…The relationship between m7G and LIHC has been marginally explored. Currently, four papers have used bioinformatics analysis to explore the relationship between m7G and LIHC (25)(26)(27)(28). They constructed different models by bioinformatics to predict valid biomarkers.…”

Section: What Is Known and What Is New?mentioning

confidence: 99%

Constructing and validating of m7G-related genes prognostic signature for hepatocellular carcinoma and immune infiltration: potential biomarkers for predicting the overall survival

Liu¹,

Dong²,

Shi³

et al. 2022

J Gastrointest Oncol

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Background: To investigate the prognostic significance of N7-methylguanosine (m7G) regulators and immune infiltration in liver hepatocellular carcinoma (LIHC).Methods: The research measured predictive m7G genes in LIHC samples from the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) datasets. Data on the stemness index based on mRNA expression (mRNAsi), gene mutations, and corresponding clinical characteristics were obtained from TCGA and ICGC. Lasso regression was used to construct the prediction model to assess the m7G prognostic signals in LIHC. Based on these genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify key biological functions and pathways. The correlation between m7G RNA methylation regulators and the prognosis and immune infiltration of LIHC was evaluated.Results: There were 21 m7G-related differentially expressed genes (DEGs) in LIHC and healthy tissues, and LIHC patients could be divided into two categories by consensus clustering of these DEGs. A fivegene predictive approach was employed using least absolute shrinkage and selection operator (LASSO) Cox regression analysis. Patients in the low-risk group showed a significantly higher survival rate compared with those in the high-risk group (P=0.001). Validations using the ICGC database. Also, univariate and multivariate Cox regression analyses suggested that the risk score produced by the predictive model is an independent predictor for LIHC [hazard ratio (HR): 1.848, 95% confidence interval (CI): 1.286-2.656; HR: 2.597, 95% CI: 1.358-4.965]. The ROC curves of the ICGC cohort revealed that the five-gene prediction model performed well [area under the curve (AUC) =0.642 at 1 year, AUC =0.686 at 2 years, and AUC =0.667 at 3 years]. Immuno-oncology scoring revealed that in the high-risk group, among 16 immune cells, the expressions of neutrophils and natural killer (NK) cells were low and that of regulatory T-cells (Tregs) was high.Conclusions: LIHC occurrence and progression are linked to m7G-related genes.

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N7-Methylguanosine Genes Related Prognostic Biomarker in Hepatocellular Carcinoma

Cited by 8 publications

References 52 publications

A novel m7G-related signature to predict prognosis and immune status in patients with hepatocellular carcinoma

A novel m7G-related signature to predict prognosis and immune status in patients with hepatocellular carcinoma

The role of anoctamin 1 in liver disease

Constructing and validating of m7G-related genes prognostic signature for hepatocellular carcinoma and immune infiltration: potential biomarkers for predicting the overall survival

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