Abstract:The effect of PEG 4000, PVP K30, poloxamer 407 and urea as carriers glycyrrhetinic acid solid dispersions (GA-SDs) on dissolution behavior and physicochemical properties were investigated. In vitro dissolution test results show that GA-SDs prepared with four different carriers have better dissolution properties compared with pure drug and corresponding physical mixtures. The enhancement effect of four carriers on dissolution rate and equilibrium solubility shows that PVP K30>PEG 4000>P 407>urea. In addition, t… Show more
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