N6-methyladenosine (m6A) reader IGF2BP2 stabilizes HK2 stability to accelerate the Warburg effect of oral squamous cell carcinoma progression

Ke, Xu; Dai, Xingxing; Wu, Jiankun; Wen, Kai

doi:10.1007/s00432-022-04093-z

Cited by 14 publications

(10 citation statements)

References 20 publications

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“…Subsequent to knocking down the expression level of IGF2BP2, the migration, cell proliferation, and invasion abilities of SCC4 were found to have considerably reduced. The outcomes of Ke et al were consistent with the current study, where a considerable attenuation in the proliferation and migration abilities of HNSCC cells was studied following a knockdown of IGF2BP2 expression20 . These results imply that IGF2BP2 might play a signi cant role in the development of HNSCC and may act as a future therapeutic target for HNSCC treatment.The objective of the current investigation was to examine the expression pattern and diagnostic and prognostic signi cance of the IGF2BPs gene family in HNSCC, along with investigating its relationship with tumor immunity to enhance comprehension of its regulation of the tumor microenvironment.…”

supporting

confidence: 89%

“…In this study, the expression level of the IGF2BPs gene family was shown to be signi cantly higher in HNSCC than in healthy head and neck tissues. Previous studies also showed that IGF2BP2 and IGF2BP3 expression levels were signi cantly greater in HNSCC tumor tissues compared to healthy control samples, and they were linked to a poor prognosis in HNSCC patients 20,21 . Furthermore, the present investigation revealed that the elevated expression level of the IGF2BPs gene family was linked to the clinical stage, T stage, and lymph node neck dissection.…”

Section: Discussionmentioning

confidence: 90%

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Comprehensive Analysis of the Expression of the IGF2BPs gene family in Head and Neck Squamous Cell Carcinoma: Association with Prognostic Value and Tumor Immunity

Tang

Liu

Zhao

2023

Preprint

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Background: Head and neck squamous cell carcinoma (HNSCC) represents a predominant type of malignant cancer found in the head and neck region, characterized by a high incidence and unfavorable prognosis. The IGF2BPs gene family, which belongs to the RNA-binding protein class, has been critically implicated in several cancers, and its involvement in HNSCC necessitates further exploration. Objective: To explore the clinical significance and potential biological functions of the IGF2BPs gene family in HNSCC. Methods: A bioinformatic methodology was employed to examine the expression profile, diagnostic and prognostic significance, and biological mechanisms of the IGF2BPs gene family in HNSCC, with a particular emphasis on its involvement in the immune function of HNSCC. This was followed by in vitro investigations to unravel the biological roles of the IGF2BPs gene family in HNSCC. Results: This investigation has demonstrated that, in contrast with normal control tissue, HNSCC has a substantial elevation in the expression level of the IGF2BPs gene family. Patients with a high level of IGF2BPs gene family expression demonstrated higher prediction accuracy for HNSCC. Furthermore, patients with HNSCC and elevated IGF2BPs gene family expression levels exhibited poor survival outcomes. The IGF2BPs gene family displayed a significant association with a variety of immune infiltrating cells and immune genes in HNSCC. Studies conducted in vitro have confirmed that IGF2BP2 silencing suppressed the migration, proliferation, and invasion of HNSCC cells. Conclusions: It has been determined that the IGF2BPs gene family plays a crucial part in the onset and progression of HNSCC, and its association with tumor immunity has been established. The IGF2BPs gene family holds promising potential as a diagnostic and prognostic biomarker for HNSCC.

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supporting

confidence: 89%

Section: Discussionmentioning

confidence: 90%

Comprehensive Analysis of the Expression of the IGF2BPs gene family in Head and Neck Squamous Cell Carcinoma: Association with Prognostic Value and Tumor Immunity

Tang

Liu

Zhao

2023

Preprint

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“…In this study, the expression level of the IGF2BPs gene family was shown to be significantly higher in HNSCC than in healthy head and neck tissues. Previous studies also showed that IGF2BP2 and IGF2BP3 expression levels were significantly greater in HNSCC tumor tissues compared to healthy control samples, and they were linked to a poor prognosis in HNSCC patients [ 21 , 22 ]. Furthermore, the present investigation revealed that the elevated expression level of the IGF2BPs gene family was linked to the clinical stage, T stage, and lymph node neck dissection.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the expression of the IGF2BPs gene family in head and neck squamous cell carcinoma: Association with prognostic value and tumor immunity

Tang,

Zhao,

Liu

2023

Heliyon

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“… 265 Moreover, upregulated IGF2BP2 has been found as a predictor of poor prognosis in CC and OSCC, which improved stability of c-MYC and HK2 mRNA, respectively. 266 , 267 Recently, Ye et al suggested that miR4458HG interacted with IGF2BP2 and activated the improvement of HK2 and GLUT1 expression in HCC. 268 In OSCC, IGF2BP3 interacted with circFOXK2 to stabilize GLUT1 mRNA.…”

Section: Rna Modifications and Cellular Metabolismmentioning

confidence: 99%

RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

Liu,

Zheng,

et al. 2024

Sig Transduct Target Ther

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Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and inspiring development of therapeutics. As a crucial component of epigenetics at post-transcription level, RNA modification significantly determines RNA fates, further affecting various biological processes and cellular phenotypes. To be noted, immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological contexts. In this review, we characterize the distribution features, modifying mechanisms and biological functions of 8 RNA modifications, including N6-methyladenosine (m6A), N6,2′-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C), N4-acetylcytosine (ac4C), N7-methylguanosine (m7G), Pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing, which are relatively the most studied types. Then regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described, categorized as glucose, lipid, amino acid, and mitochondrial metabolism. And we highlight the regulation of RNA modifications on immunometabolism, further influencing immune responses. Above all, we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy, progression of RNA modification-targeted agents, and its potential in RNA-targeted therapeutics. Eventually, we give legitimate perspectives for future researches in this field from methodological requirements, mechanistic insights, to therapeutic applications.

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N6-methyladenosine (m6A) reader IGF2BP2 stabilizes HK2 stability to accelerate the Warburg effect of oral squamous cell carcinoma progression

Cited by 14 publications

References 20 publications

Comprehensive Analysis of the Expression of the IGF2BPs gene family in Head and Neck Squamous Cell Carcinoma: Association with Prognostic Value and Tumor Immunity

Comprehensive Analysis of the Expression of the IGF2BPs gene family in Head and Neck Squamous Cell Carcinoma: Association with Prognostic Value and Tumor Immunity

Comprehensive analysis of the expression of the IGF2BPs gene family in head and neck squamous cell carcinoma: Association with prognostic value and tumor immunity

RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

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