N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases

Paramasivam, Arumugam; Priyadharsini, J. Vijayashree; Raghunandhakumar, Subramanian

doi:10.1038/s41440-019-0338-z

Cited by 127 publications

(82 citation statements)

References 10 publications

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“…The dysregulation of methyltransferase, demethylases and m 6 A-binding proteins plays a role in the occurrence and progression of CVD. Studies have demonstrated that the regulation of these 'writers', 'erasers' and 'readers' may alleviate the progression of cardiac diseases; these modulators might provide a novel insight into potential diagnostic biomarkers or therapeutic strategies for CVD ( 143 ). Table II and Fig.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Role of m6A RNA methylation in cardiovascular disease (Review)

et al. 2020

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N 6 -methyladenosine (m 6 A) is the most prevalent and abundant type of internal post-transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including mRNAs, rRNAs, tRNAs, long non-coding RNAs and microRNAs, are involved in m 6 A methylation. The biological function of m 6 A modification is dynamically and reversibly mediated by methyltransferases (writers), demethylases (erasers) and m 6 A binding proteins (readers). The methyltransferase complex is responsible for the catalyzation of m 6 A modification and is typically made up of methyltransferase-like (METTL)3, METTL14 and Wilms tumor 1-associated protein. Erasers remove methylation by fat mass and obesity-associated protein and ALKB homolog 5. Readers play a role through the recognition of m 6 A-modified targeted RNA. The YT521-B homology domain family, heterogeneous nuclear ribonucleoprotein and insulin-like growth factor 2 mRNA-binding protein serve as m 6 A readers. The m 6 A methylation on transcripts plays a pivotal role in the regulation of downstream molecular events and biological functions, such as RNA splicing, transport, stability and translatability at the post-transcriptional level. The dysregulation of m 6 A modification is associated with cancer, drug resistance, virus replication and the pluripotency of embryonic stem cells. Recently, a number of studies have identified aberrant m 6 A methylation in cardiovascular diseases (CVDs), including cardiac hypertrophy, heart failure, arterial aneurysm, vascular calcification and pulmonary hypertension. The aim of the present review article was to summarize the recent research progress on the role of m 6 A modification in CVD and give a brief perspective on its prospective applications in CVD.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Role of m6A RNA methylation in cardiovascular disease (Review)

et al. 2020

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“…Recent studies show that m 6 A modification is closely related to blood pressure (BP) and cardiovascular diseases [106]. For example, the m 6 A-SNP (Lys67Arg, rs197922) in golgi SNAP receptor complex member 2 gene is positively associated with hypertension in white individuals [107].…”

Section: A Methylation In Hypertension and Cardiovascular Diseasesmentioning

confidence: 99%

RNA N6-methyladenosine: a promising molecular target in metabolic diseases

Wang

Huang

et al. 2020

Cell Biosci

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N6-methyladenosine is a prevalent and abundant transcriptome modification, and its methylation regulates the various aspects of RNAs, including transcription, translation, processing and metabolism. The methylation of N6-methyladenosine is highly associated with numerous cellular processes, which plays important roles in the development of physiological process and diseases. The high prevalence of metabolic diseases poses a serious threat to human health, but its pathological mechanisms remain poorly understood. Recent studies have reported that the progression of metabolic diseases is closely related to the expression of RNA N6-methyladenosine modification. In this review, we aim to summarize the biological and clinical significance of RNA N6-methyladenosine modification in metabolic diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, hypertension, cardiovascular diseases, osteoporosis and immune-related metabolic diseases.

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“…Everyday preventive measures such as hand washing, avoiding contact with sick individuals, and good hygiene can go a long way in reducing your risk for viruses, bacteria, and other pathogens. People with diabetes, respiratory illness, cardiac problems and hypertension are more prone to the diseases (Paramasivam et al, 2020). In addi- tion, however, there is evidence that nutrition and other lifestyle measures in luence immune strength and susceptibility to infectious diseases.…”

Section: Resultsmentioning

confidence: 99%

Knowledge and Awareness about Natural Immune Booster Among General Public

Lakshmi

Geetha

2020

ijrps

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The immune system plays a vital role in protecting the body against diseases, fighting against foreign bodies and does a remarkable job in defending against microorganism and distinguishing bodies' own health issues and protecting them from infectious agents. Natural immune boosters are the product, which helps in boosting the immune system. Even some pharmaceutical preparation includes medicinal plants as they are compound extract again is a variety of diseases. Ayurvedic theory states that balance between the humours of the body that is “vayu, pitta and kaffa” leads to healthy living. The bottom line Herbs have been used as natural remedies like mouthwash, toothpaste, etc. since ancient times. An online survey was conducted among 100 general public to assess their knowledge and awareness about natural immune boosters. The online survey includes 15 questions based on immune boosters. The Results said that about 97% are aware of immune boosters and also about 95% think it's important to boost immunity. A total of hundred people of Chennai, Kancheepuram and Tiruvallur district of Tamil Nadu attended this survey. In the study, we observe that about 97 % of them are aware of natural boosters, and 95 % say it is important to boost their immunity. Eating a low-fat, plant-based diet may help give the immune system to boost. The immune system relies on white blood cells that produce antibodies to combat bacteria, viruses, and other invaders.

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N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases

Cited by 127 publications

References 10 publications

Role of m6A RNA methylation in cardiovascular disease (Review)

Role of m6A RNA methylation in cardiovascular disease (Review)

RNA N6-methyladenosine: a promising molecular target in metabolic diseases

Knowledge and Awareness about Natural Immune Booster Among General Public

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