N2O4/SiO2 system as an efficient reagent for rapid and chemoselective conversion of trimethylsilyl ethers to the parent alcohols under nonaqueous conditions

Abstract

N 2 O 4 was easily impregnated on silica gel to give a stable heterogeneous reagent N 2 O 4 /SiO 2 (I). Chemoselective deprotection of trimethylsilyl ethers to the corresponding alcohols was achieved in the presence of I in CH 2 Cl 2 in excellent yields. The stability, easy preparation and high selectivity of the reagent make this method as a useful procedure for the selective deprotection of TMS ethers at room temperature.

A One-Pot synthesis of 1,2-Dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-one Derivatives catalyzed by Perchloric Acid Supported on Silica (HClO4/SiO2) in the absence of solvent

“…Solid-phase organic synthesis is a subject of recent interest in the context of generating libraries of molecules for the discovery of biologically active leads and also for the optimization of potent drug candidates [9]. Moreover, *Corresponding author.…”