N2 lung cancer: Outcome in patients with false-negative computed tomographic scans of the chest

Daly, Benedict D.T.; Mueller, Johannes; Faling, L. Jack; Diehl, James T.; Bankoff, Mark S.; Karp, Daniel D.; Rand, William; Mark, James B.D.; Mckneally, MartinF.; Faber, L. Penfield

doi:10.1016/s0022-5223(19)34164-9

Cited by 78 publications

(19 citation statements)

References 22 publications

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“…Many physicians believe in their inability to control N2 disease by surgical treatment and regard it as a contraindication to thoracotomy, but some of these lesions demonstrate relatively fine prognosis after complete resection. 1,2 Varying survival associated with the surgical treatment of…”

mentioning

confidence: 99%

Prognosis of completely resected pn2 non–small cell lung carcinomas: What is the significant node that affects survival?

Okada¹,

Tsubota²,

Yoshimura³

et al. 1999

The Journal of Thoracic and Cardiovascular Surgery

102

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mentioning

confidence: 99%

Prognosis of completely resected pn2 non–small cell lung carcinomas: What is the significant node that affects survival?

Okada¹,

Tsubota²,

Yoshimura³

et al. 1999

The Journal of Thoracic and Cardiovascular Surgery

102

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“…A lthough most patients with clinical N2 non-small cell lung cancer are not candidates for surgical treatment, the opportunity for cure should not be denied, because some of these patients have a relatively good prognosis after complete resection. [1][2][3] Therefore, we thought that patients with known N2 disease might be candidates for surgical treatment. 4 There have been reports showing that patients with involvement of multiple N2 nodal stations have worse prognoses than those with involvement of only single N2 nodal stations.…”

mentioning

confidence: 99%

Induction Therapy for Non-small Cell Lung Cancer With Involved Mediastinal Nodes in Multiple Stations

Okada

Tsubota

Yoshimura

et al. 2000

Chest

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“…Previous studies have been performed to evaluate the accuracy of CT or Tl-201 SPECT in the evaluation of mediastinal node involvement. 3 –10,12 –14 However, most of these studies demonstrated a diagnostic value of single examination separately, and very little attention has been given to the combined examination with CT, Tl-201 SPECT and serum CEA level. Our results show that the combined examination of mediastinal nodal involvement with CT, Tl-201 SPECT and serum CEA level might increase underestimation, but decrease overestimation.…”

Section: Discussionmentioning

confidence: 99%

“…Computed tomography (CT) is the imaging modality used most commonly for preoperative non-invasive mediastinal staging. 3 –8 However, CT criteria have been reported to yield a high false-positive result rate and some investigators reported that one third of patients with enlarged mediastinal lymph nodes on CT scan did not have nodal involvement. 9,10 Therefore, the reliability of CT size criteria for node metastasis remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Combined Procedures for Mediastinal Staging in Non-Small Cell Lung Cancer

Tomita

Matsuzaki

Edagawa

et al. 2004

Asian Cardiovasc Thorac Ann

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We investigated whether the combined use of computed tomography, thallium-201 single photon emission computed tomography and serum carcinoembryonic antigen level improves preoperative non-invasive mediastinal. 128 consecutive non-small cell lung cancer patients (85 adenocarcinomas, 31 squamous cell carcinomas and 12 others) who underwent a surgical resection were enrolled in this study. The results of the combined procedures were compared with the pathologic findings. Our results showed that the combined evaluation of mediastinal nodal involvement with the three procedures might increase underestimation, but decrease overestimation as compared to computed tomography alone. Thallium-201 single photon emission computed tomography for patients with enlarged nodes at computed tomography showed 81.3% and 100% of positive predictive value in overall and squamous cell carcinoma patients, respectively. The negative predictive value of thallium-201 single photon emission computed tomography for patients without enlarged nodes at computed tomography was highly accurate in adenocarcinoma (93.9%) as well as squamous cell carcinoma (94.4%). Combining computed tomography findings and serum carcinoembryonic antigen level had a poor predictive value. However, in patients with adenocarcinoma, a negative examination was highly accurate (95.2%). In conclusion, our results show a trend that combined use of the three procedures might improve non-invasive mediastinal staging in non-small cell lung cancer.

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N2 lung cancer: Outcome in patients with false-negative computed tomographic scans of the chest

Cited by 78 publications

References 22 publications

Prognosis of completely resected pn2 non–small cell lung carcinomas: What is the significant node that affects survival?

Prognosis of completely resected pn2 non–small cell lung carcinomas: What is the significant node that affects survival?

Induction Therapy for Non-small Cell Lung Cancer With Involved Mediastinal Nodes in Multiple Stations

Combined Procedures for Mediastinal Staging in Non-Small Cell Lung Cancer

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