N0n Narcotic Analgesics and Prostaglandins

Deraedt, R.; Jouquey, Simone; Benzoni, J.; Peterfalvi, M

doi:10.1016/b978-0-08-021308-8.50810-3

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Collier et al 16) postulated that the acetic acid acts indirectly by inducing the release of endogenous mediators sensitive to nonsteroidal anti-inflammatory drugs and opioids. Deraedt et al 17,18) related that inhibition of the acetic acid writhing in mice causes an acute inflammatory reaction related to the increase in the peritoneal fluid levels of PGE2 and PGF2a.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Activities of the Hydroalcoholic Extracts from Erythrina velutina and Erythrina mulungu in Mice

Vasconcelos

Oliveira

Carvalho

et al. 2003

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

This work studied the antinociceptive effects of the hydroalcoholic extracts (HAEs) from Erythrina velutina (Ev) and Erythrina mulungu (Em) in three experimental models of nociception in mice. The extract was administered intraperitoneally to female mice at the doses of 200 and 400 mg/kg. Inhibitions of abdominal contractions were observed with the doses of 200 (88.6%; 86.8%) and 400 (95.5%; 83.5%) mg/kg of E. velutina and E. mulungu, respectively, as compared to controls. E. velutina and E. mulungu, at both doses, reduced the nociception produced by formalin in the 1st and 2nd phases and this effect was not reversed by the pretreatment with naloxone. In the hot plate test an increase of the reaction time was observed only at 60 (Ev=18.0+/-2.2; Em=20.8+/-2.52) and 90 min (Ev=20.4+/-1.71; Em=23.7+/-2.32) after the treatment with E. velutina and E. mulungu at the dose of 400 mg/kg as compared to controls (T60=11.1+/-0.74; T90=11.9+/-0.86). This effect was not reversed by naloxone. We conclude that E. velutina and E. mulungu presents antinociceptive effects, which are independent of the opioid system.

show abstract

Section: Discussionmentioning

confidence: 99%

Antinociceptive Activities of the Hydroalcoholic Extracts from Erythrina velutina and Erythrina mulungu in Mice

Vasconcelos

Oliveira

Carvalho

et al. 2003

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…[5], [6], and [7] that the angular momentum p at time T which is denoted by p,, is given as with Jacobi's cn and dn functions. Equation [8] is essentially same as the well-known solution for a simple pendulum. The expressions for k < 1 and k > 1 represent oscillatory and rotatory motion, respectively.…”

Section: Classical Mechanical Modementioning

confidence: 67%

“…This solution is obtained by replacing sign ( p O )~ by u + sign ( p , )~ in eqs. [7] and [8]. Because of the range of + ' , we have the limitation …”

Section: Classical Mechanical Modementioning

confidence: 99%

Dynamics of a one-dimensional classical hindered rotor

Yasuda¹,

Raich²

1988

Can. J. Chem.

View full text Add to dashboard Cite

This paper is dedicated to Professor J. A. MorrisonHIDEO YASUDA and JOHN C. RAICH. Can. J. Chem. 66, 752 (1988). The dynamic susceptibility of a one-dimensional rotor in crystal fields of various symmetry is calculated within the framework of classical mechanics. The contributions from oscillatory and rotary motions are treatable separately. This approach serves to clarify the structure of the spectrum. The nature and magnitude of the quantum effect are investigated and a comparison with earlier quantum mechanical calculations is made.HIDEO YASUDA et JOHN C. RAICH. Can. J. Chem. 66, 752 (1988). Utilisant les principes de la mCcanique classique, on a calculC la susceptibilitC dynamique d'un rotor unidimensionnel dans des champs cristallins de diverses symCtries. Les contributions dies aux mouvements oscillatoires et rotatoires ont CtC traitCs skparCment. Cette mCthode permet de clarifier la structure du spectre. On a CtudiC la nature et l'amplitude de l'effet quantique et on a fait une comparaison avec des calculs de mCcanique quantique qui ont CtC effectuCs antkrieurement.[Traduit par la revue]

show abstract

“…37) Moreover, JCICM-6 may block the effect or the release of endogenous substances, including PGE 2 that excites pain nerve endings and is found in writhing response test model of mice. 38) Taken together, JCICM-6 could act in earlier and later phases of inflammation. The underlying mechanisms may be that JCICM-6 could inhibit the synthesis, release, or actions of pro-inflammatory mediators; meanwhile, JCICM-6 could also act as a lipoxygenase or cyclooxygenase inhibitors.…”

Section: Discussionmentioning

confidence: 99%