N-vinylamides and related polymers as delivery agents of biologically active compounds

Panarin, E. F.

doi:10.1007/s11172-015-0813-x

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…On the other hand, concerning noncyclic N -vinylamide monomers, industrial N -vinylformamide (NVF), N -vinylacetamide (NVA), and N -methyl- N -vinylacetamide (NMVA) are precursors of homopolymers and copolymers widely used in biomedicine as drug-delivery agents, − in water-treatment, − as kinetic hydrate inhibitors in the petroleum industry, − or even in batteries − and textile industries. , Advantageously, they are also a major source of polyvinylamines, − thus providing a powerful tool to generate cationic interfaces and form complexes with metals or with oppositely charged polyelectrolytes . Unlike N -vinyllactams, only a few studies reported the successfully controlled polymerization of noncyclic N -vinylamides with the works of Debuigne and co-workers using CMRP , and Yamago and co-workers using TERP .…”

Section: Introductionmentioning

confidence: 99%

RAFT Polymerization of N-Methyl-N-vinylacetamide and Related Double Hydrophilic Block Copolymers

et al. 2022

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Bulk reversible addition−fragmentation chain-transfer polymerization (RAFT) of N-methyl-N-vinylacetamide (NMVA) was explored with four different RAFT agents, which are two xanthates and two dithiocarbamates. Working at 35 °C with an unusually high [V-70] 0 /[RAFT agent] 0 ratio, cyanomethyl O-ethyl carbonodithioate and cyanomethyl diphenylcarbamodithioate allowed the synthesis of poly(N-methyl-N-vinyl acetamide) (PNMVA) with predetermined M n and relatively low dispersities (Đ < 1.5). A good thiocarbonylthio end-group fidelity was revealed by 1 H nuclear magnetic resonance (NMR), mass spectrometry, chain-extension experiment, and block copolymer synthesis. Two double hydrophilic poly(ethylene oxide)-b-poly(N-methyl-N-vinylacetamide) (PEO-b-PNMVA) and poly(N-isopropylacrylamide)-bpoly(N-methyl-N-vinylacetamide) (PNIPAAm-b-PNMVA) diblock copolymers were successfully synthesized, the latter of which exhibits a lower critical solution temperature (LCST) with the reversible formation of colloidal aggregates in water.

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Section: Introductionmentioning

confidence: 99%

RAFT Polymerization of N-Methyl-N-vinylacetamide and Related Double Hydrophilic Block Copolymers

et al. 2022

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“…N-vinylamides belong to the class of flexible chain polymers and can also be regarded as promising polymeric carriers for radioactive isotopes. These polymers have been comprehensively studied and are used in clinical practice as plasma substituents and transporters of low molecular weight biologically active compounds [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules

et al. 2020

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Copolymer of N-vinylpyrrolidone (VP) with vinylformamide (VFA) and N-vinyliminodiacetic acid (VIDA) was synthesized; its metal-polymer complexes (MPCs) with gallium were obtained. The complexes were characterized by size exclusion chromatography, hydrodynamic and optical methods, scanning electron microscopy, and spectral methods (UV, IR, 1Н NMR spectroscopy). It was demonstrated that in going from polymer to complex, hydrodynamic parameters of macromolecules change only slightly, although the polymer contains intramolecular Ga(VIDA)2 fragments in its structure. A new method for preparation of MPCs with gallium and gallium-68 radionuclide was suggested. The obtained metal-polymer complex is stable over a wide range of pH values as well as in the histidine challenge reaction. In vivo distribution experiments in intact animals showed high primary accumulation of thegallium-68 MPC in blood with subsequent excretion via urinary tract.

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“…However, it can be stated that for random water-soluble copolymers of [N-VP] n -[N-VA] m (when the percentage of the second component does not exceed 15 mol.%) this calculation of the “relative” AMM may be useful. On the whole, the MM and polydispersities of the obtained series of copolymers are relatively small and meet the requirements imposed on polymeric carriers for medicinal preparations [ 9 , 12 , 16 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Water-soluble carbochain polymers based on poly-N-vinylamides are frequently used as such polycations in various areas of pharmaceutics and medicine [ 1 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy

et al. 2021

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N-vinylamides and related polymers as delivery agents of biologically active compounds

Cited by 11 publications

References 38 publications

RAFT Polymerization of N-Methyl-N-vinylacetamide and Related Double Hydrophilic Block Copolymers

RAFT Polymerization of N-Methyl-N-vinylacetamide and Related Double Hydrophilic Block Copolymers

Metal-Polymer Complexes of Gallium/Gallium-68 with Copolymers of N-Vinylpyrrolidonewith N-Vinylformamideand N-Vinyliminodiacetic Acid: A Hint for Radiolabeling of Water-Soluble Synthetic Flexible Chain Macromolecules

Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy

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