N-terminal prohormone of brain natriuretic peptide: a useful tool for the detection of acute pulmonary artery embolism in post-surgical patients

Winkler, Bernd; Schuetz, W; Froeba, G.; Muth, Claus M.

doi:10.1093/bja/aes315

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…BNP released from ventricular myocytes is a powerful predictor in cardiovascular disease patients with atrial fibrillation, correlating with higher post-stroke mortality and cardio-embolic stroke ( 28 ). Additionally, elevated serum BNP levels are also reported in acute pulmonary embolism patients ( 29 ). Plasma BNP has also been reported by many studies as a prognostic indicator in patients with primary PH due to some degree of right ventricular dysfunction ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Yin

Yang

Feng

et al. 2016

Braz J Med Biol Res

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We investigated the risk factors for pulmonary hypertension (PH) in patients receiving maintenance peritoneal dialysis (MPD). A group of 180 end-stage renal disease patients (124 men and 56 women; mean age: 56.43±8.36) were enrolled in our study, which was conducted between January 2009 and June 2014. All of the patients received MPD treatment in the Dialysis Center of the Second Affiliated Hospital of Soochow University. Clinical data, laboratory indices, and echocardiographic data from these patients were collected, and follow-ups were scheduled bi-monthly. The incidence and relevant risk factors of PH were analyzed. The differences in measurement data were compared by t-test and enumeration data were compared with the χ2 test. Among the 180 patients receiving MPD, 60 were diagnosed with PH. The remaining 120 were regarded as the non-PH group. Significant differences were observed in the clinical data, laboratory indices, and echocardiographic data between the PH and non-PH patients (all P<0.05). Furthermore, hypertensive nephropathy patients on MPD showed a significantly higher incidence of PH compared with non-hypertensive nephropathy patients (P<0.05). Logistic regression analysis showed that the proportion of internal arteriovenous fistula, C-reactive protein levels, and ejection fraction were the highest risk factors for PH in patients receiving MPD. Our study shows that there is a high incidence of PH in patients receiving MPD and hypertensive nephropathy patients have an increased susceptibility to PH.

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Section: Discussionmentioning

confidence: 99%

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Yin

Yang

Feng

et al. 2016

Braz J Med Biol Res

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“…Several previous studies investigated the role of biomarkers in the context of PE. Winkler et al 28 examined the value of N -terminal pro-brain natriuretic peptide (NT-proBNP) as a biomarker for acute PE diagnosis in the postoperative setting. NT-proBNP was found to be a useful biomarker for acute PE diagnosis in the postoperative setting.…”

Section: Discussionmentioning

confidence: 99%

“…NT-proBNP was found to be a useful biomarker for acute PE diagnosis in the postoperative setting. 28 Xiao et al 29 reported that plasma microRNA-134 could be an important biomarker for the diagnosis of acute PE.…”

Section: Discussionmentioning

confidence: 99%

Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis

Sevük¹,

Bahadır²,

Altındağ³

et al. 2015

TCRM

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Background: To date, no validated biomarkers with high sensitivity and specificity have been established for diagnosis of pulmonary embolism (PE) in patients with deep venous thrombosis (DVT). There is a need to develop simple and reliable noninvasive tests that can accurately identify patients with PE, even in small hospitals or clinics. The aim of this study was to investigate the value of mean platelet volume (MPV) and platelet distribution width (PDW) for predicting occurrence of PE in patients with DVT. Methods: Records of acute DVT patients were reviewed retrospectively. Group 1 consisted of 50 patients with acute DVT and group 2 consisted of 50 patients with acute DVT who developed PE during follow-up. The control group consisted of patients with uncomplicated primary varicose veins of the lower limbs. Venous peripheral blood samples for measurement of MPV, PDW, and platelet count were drawn on admission, before the treatment, and at the time of PE diagnosis. Results: MPV and PDW levels at the time of PE diagnosis were higher in group 2 than group 1 (P,0.001 and P=0.026, respectively). Receiver operating characteristics analysis revealed that a 5.2% increase in admission PDW during follow-up provided 70% sensitivity and 82% specificity (area under the curve, 0.80), and a 6.6% increase in admission MPV during follow-up provided 74% sensitivity and 83% specificity (area under the curve, 0.84) for prediction of PE occurrence in patients with DVT. PDW and MPV levels at the time of PE diagnosis were found to be independent risk factors for the occurrence of PE in patients with DVT. Conclusion: Serial measurements of MPV and PDW, and percent change in MPV and PDW appears to be a useful marker for predicting occurrence of acute PE in patients with a first episode of acute proximal DVT.

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“… 8 BNP was found to be useful in the detection of acute PE in postsurgical patients, where D-dimer levels are frequently elevated and therefore not discriminatory. 9 Finally, increased levels of BNP have been shown to be a marker for right ventricle dysfunction, and higher levels correlate with an increase in morbidity and mortality in acute PE. 10 …”

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confidence: 99%

Diagnosing Pulmonary Embolism in Pregnancy: Are Biomarkers and Clinical Predictive Models Useful?

Parilla

Fournogerakis

Archer

et al. 2016

AJP Rep

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Objective The objective of this study was to evaluate whether trimester-specific D-dimer levels or the modified Wells score (MWS) is a useful risk stratification tool to exclude pregnant women at low risk of pulmonary embolism (PE) from diagnostic imaging. Study Design This is a prospective and retrospective cohort study. Pregnant women who underwent diagnostic imaging for suspected PE were prospectively enrolled. D-dimer serum levels were drawn, and a MWS was assigned. Pregnant women diagnosed with a PE before study launch who underwent diagnostic imaging and had a D-dimer level drawn were also evaluated. Results In this study, 17 patients were diagnosed with a PE and 42 patients had no PE on diagnostic imaging. Sixteen out of 17 patients with a PE versus 11 out of 42 without PE had an abnormal D-dimer level (p = 0.001). Four patients with a PE versus zero without a PE had an abnormal MWS (p = 0.005). The combination of a trimester-specific D-dimer level along with the MWS was abnormal in all 17 patients with a documented PE versus 11/42 (26.2%) patients without a documented PE (p = 0.001). Conclusion A combination of trimester-specific D-dimer levels along with a MWS can be used in pregnancy to triage women into a low-risk category for PE and thereby avoid radiation exposure in a majority of pregnant patients.

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N-terminal prohormone of brain natriuretic peptide: a useful tool for the detection of acute pulmonary artery embolism in post-surgical patients

Cited by 5 publications

References 26 publications

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis

Diagnosing Pulmonary Embolism in Pregnancy: Are Biomarkers and Clinical Predictive Models Useful?

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N-terminal prohormone of brain natriuretic peptide: a useful tool for the detection of acute pulmonary artery embolism in post-surgical patients

Cited by 5 publications

References 26 publications

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Value of serial platelet indices measurements for the prediction of pulmonary embolism in&nbsp;patients&nbsp;with deep venous thrombosis

Diagnosing Pulmonary Embolism in Pregnancy: Are Biomarkers and Clinical Predictive Models Useful?

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Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis